Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

ras GENES

1987 • 3,818 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Sequence dependence of protein isoprenylation

1991 • 580 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

1991 • 312 citations

Identification of Ras farnesyltransferase inhibitors by microbial screening.

1993 • 259 citations

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

1993 • 257 citations

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

1990 • 222 citations

The induction of oocyte maturation: transmembrane signaling events and regulation of the cell cycle

1989 • 189 citations

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.

1992 • 187 citations

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

1991 • 183 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin.

1992 • 95 citations

Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity.

1993 • 84 citations

Solid-phase synthesis and biological properties of .psi.[CH2NH] pseudopeptide analogs of a highly potent somatostatin octapeptide

1987 • 84 citations

The ras/cholesterol connection: implications for ras oncogenicity.

1992 • 78 citations

A novel prenyltransferase for a small GTP-binding protein having a C-terminal Cys-Ala-Cys structure.

1991 • 69 citations

Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation.

1992 • 63 citations

Prenylation of mammalian Ras protein in Xenopus oocytes.

1990 • 44 citations

10'-Desmethoxystreptonigrin, a novel analog of streptonigrin.

1992 • 37 citations

Evidence that the ras oncogene-encoded p21 protein induces oocyte maturation via activation of protein kinase C.

1992 • 31 citations

Inhibition of protein prenylation by patulin

1993 • 30 citations

Prenoids and palmitate: lipids that control the biological activity of Ras proteins.

1992 • 26 citations