Tyrosine kinase signal transduction in rheumatoid synovitis

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Important Advances in Oncology: 1986

1986 • 912 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Important Advances in Oncology

1991 • 768 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

1986 • 478 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.

1989 • 320 citations

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1989 • 316 citations

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells

1984 • 296 citations

PARAQUAT POISONING

1976 • 280 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta.

1990 • 264 citations

Active and latent forms of transforming growth factor beta activity in synovial effusions.

1989 • 258 citations

INDUCTION OF B-TYPE RECEPTORS FOR PLATELET-DERIVED GROWTH FACTOR IN VASCULAR INFLAMMATION: POSSIBLE IMPLICATIONS FOR DEVELOPMENT OF VASCULAR PROLIFERATIVE LESIONS

1988 • 247 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.

1990 • 232 citations

Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen.

1986 • 231 citations

Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain.

1990 • 228 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

All Autophosphorylation Sites of Epidermal Growth Factor (EGF) Receptor and HER2/neu Are Located in Their Carboxyl-terminal Tails

1989 • 213 citations

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

1989 • 196 citations

Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.

1989 • 191 citations

Ligand-induced dimerization of the platelet-derived growth factor receptor

1989 • 190 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

Epidermal growth factor binding induces a conformational change in the external domain of its receptor.

1989 • 175 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization.

1989 • 161 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene

1984 • 158 citations

Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: immunologically mediated and effector cell-independent effects.

1987 • 153 citations

Expression of the c-myb oncogene in human small cell lung carcinoma.

1985 • 113 citations

Expression pattern of the neu (NGL) gene-encoded growth factor receptor protein (p185neu) in normal and transformed epithelial tissues of the digestive tract.

1989 • 112 citations

Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity.

1988 • 103 citations

Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription.

1989 • 101 citations

Expression of Platelet‐Derived Growth Factor Receptors is Induced on Connective Tissue Cells During Chronic Synovial Inflammation

1988 • 94 citations

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

1989 • 90 citations

Linkage of tyrosine kinase activity with transforming ability of the p185neu oncoprotein.

1989 • 89 citations

An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions.

1987 • 85 citations

Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.

1988 • 83 citations

Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1.

1991 • 77 citations

Identification of autophosphorylation sites of HER2/neu.

1990 • 76 citations

Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products.

1988 • 76 citations

Suppression of human synovial cell proliferation by dihomo‐γ‐linolenic acid

1989 • 64 citations

Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis.

1990 • 61 citations

Synoviocytes synthesize, bind, and respond to basic fibroblast growth factor

1990 • 56 citations

Radioimmunodetection of human glioma xenografts by monoclonal antibody to epidermal growth factor receptor.

1987 • 53 citations

Characterization of a novel anti-peptide antibody that recognizes a specific conformation of the platelet-derived growth factor receptor.

1988 • 46 citations

Stimulation of human synovial fibroblast DNA synthesis by platelet-derived growth factor and fibroblast growth factor. Differences to the activation by IL-1.

1989 • 46 citations

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site

1988 • 46 citations

Human epidermal growth factor for the stratification of synovial lining layer and neovascularisation in rheumatoid arthritis.

1989 • 28 citations

Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor β require transforming growth factor α or epidermal growth factor

1983 • 28 citations

Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells

1984 • 25 citations

Release of a Phorbol Ester-Induced Mitogenic Block by Mutation at Thr-654 of the Epidermal Growth Factor Receptor

1988 • 24 citations

Gene amplification of C-myc and N-myc in small cell carcinoma of the lung

1987 • 17 citations

Oncogenic Potential of the Human Platelet-derived Growth Factor Transcriptional Unit

1986 • 10 citations

Characterization of a Novel Anti-Peptide Antibody That Recognizes a Specific Conformation of the Platelet-Derived Growth Factor Receptor

1988 • 7 citations