α‐adrenoceptors: Recent developments

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Ciba foundation symposium

1964 • 2,217 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Presynaptic regulation of catecholamine release

1974 • 1,145 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

On some physiological actions of ergot

1906 • 980 citations

A functional basis for classification of α-adrenergic receptors

1977 • 802 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

Alpha 1-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+.

1988 • 566 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle

1987 • 482 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H]WB4104 and [3H]prazosin binding.

1986 • 456 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

Relative pre- and postsynaptic potencies of ?-adrenoceptor agonists in the rabbit pulmonary artery

1975 • 455 citations

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

1988 • 440 citations

Studies on the relationship between chemical constitution and physiological action

1933 • 437 citations

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

1990 • 417 citations

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

1983 • 406 citations

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

1991 • 401 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Evidence for more than one type of post-junctional α-Adrenoceptor

1982 • 399 citations

Sub types of α2-adrenoceptors: Pharmacological and molecular biological evidence converg

1988 • 379 citations

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol.

1958 • 373 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms

1988 • 339 citations

Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA.

1991 • 334 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Pharmacological subclassification of α₁‐adrenoceptors in vascular smooth muscle

1990 • 308 citations

Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype.

1988 • 307 citations

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

1980 • 298 citations

Heterogeneity of alpha-2 adrenergic receptors

1985 • 297 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

1979 • 288 citations

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

1990 • 287 citations

Phospholipids as ionophores.

1976 • 275 citations

Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit

1979 • 273 citations

Inositol phospholipids in membrane function

1979 • 272 citations

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

1990 • 270 citations

TPA-induced contraction of isolated rabbit vascular smooth muscle

1984 • 266 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.

1984 • 249 citations

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

1987 • 248 citations

Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype

1991 • 220 citations

Phorbol ester-induced contraction of arterial smooth muscle and inhibition of α-adrenergic response

1984 • 216 citations

α1-Adrenoceptor subclassification in vascular smooth muscle

1986 • 215 citations

Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic response in rat left ventricular papillary muscles.

1988 • 210 citations

5-Methyl-urapidil discriminates between subtypes of the α1-adrenoceptor

1988 • 208 citations

THE PHARMACOLOGY OF ADRENERGIC BLOCKADE

1949 • 203 citations

Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.

1992 • 201 citations

Structure and function of alpha-adrenoceptors.

1991 • 201 citations

Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships

1991 • 191 citations

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors

1989 • 173 citations

Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: Evidence for an ?-receptor-mediated feed-back inhibition of noradrenaline release

1972 • 172 citations

Molecular characterization of a rat alpha 2B-adrenergic receptor.

1990 • 163 citations

Plasma membrane calcium flux, protein kinase C activation and smooth muscle contraction.

1985 • 163 citations

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.

1992 • 160 citations

Molecular characterization of α1- and α2-adrenoceptors

1991 • 153 citations

Cloning, sequence analysis, and permanent expression of a human α2-adrenergic receptor in Chinese hamster ovary cells

1989 • 152 citations

Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats.

1983 • 150 citations

Molecular geometry and adrenergic drug activity.

1974 • 146 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

Slow interaction of islet-activating protein with pancreatic islets during primary culture to cause reversal of alpha-adrenergic inhibition of insulin secretion.

1980 • 143 citations

Subtypes of α1adrenoceptors in rat blood vessels

1990 • 141 citations

Differential inhibiton of alpha-1 and alpha-2 adrenoceptor-mediated pressor responses in pithed rats.

1980 • 132 citations

Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification.

1990 • 131 citations

Identification and characterization of alpha 2D-adrenergic receptors in bovine pineal gland.

1991 • 126 citations

Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

1990 • 117 citations

Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line.

1988 • 112 citations

Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol trisphosphate increase in mammalian heart.

1988 • 110 citations

Pharmacological characterization of rat alpha 2-adrenergic receptors.

1991 • 110 citations

Distribution of α2-adrenergic receptor mRNAs in the rat CNS

1991 • 109 citations

Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes

1989 • 109 citations

Quantum mechanical study of the conformational properties of phenethylamines of biochemical and medicinal interest

1972 • 105 citations

Differentiation of alpha 1-adrenergic receptors linked to phosphatidylinositol turnover and cyclic AMP accumulation in rat brain.

1987 • 104 citations

Differences between the α₂‐adrenoceptor in rat submaxillary gland and the α_2A‐ and α_2B‐adrenoceptor subtypes

1989 • 103 citations

Sequence of a rat brain cDNA encoding an alpha-1B adrenergic receptor

1990 • 98 citations

Lack of cross-desensitization between structurally dissimilar α-adrenoceptor agonists

1977 • 97 citations

Purification and characterization of the human platelet alpha 2-adrenergic receptor.

1986 • 94 citations

Nuclear magnetic resonance spectroscopy. XIII. Amidines. VII. Proton and carbon-13 nuclear magnetic resonance studies on the tautomerism, geometrical isomerism, and conformation of some cyclic amidines, guanidines, and related systems

1975 • 91 citations

Relationships Between Stereostructure and Pharmacological Activities

1970 • 91 citations

Alpha 2-adrenergic inhibition of insulin secretion via interference with cyclic AMP generation in rat pancreatic islets.

1982 • 90 citations

[³H]‐MK 912 binding delineates two α₂‐adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d α₂‐adrenoceptor

1992 • 89 citations

Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain

1986 • 88 citations

.alpha.-Adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic .alpha.2-adrenoreceptor antagonists and potential antidepressants

1983 • 84 citations

Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.

1986 • 81 citations

Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.

1984 • 81 citations

Net calcium fluxes in rat parotid acinar cells

1982 • 81 citations

Islet-activating protein (pertussis toxin) diminishes ?2-adrenoceptor mediated effects on noradrenaline release

1985 • 80 citations

Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive .alpha.-adrenergic antagonists

1977 • 79 citations

Steric Aspects of Adrenergic Drugs

1970 • 79 citations

Alpha-2A and alpha-2B adrenergic receptor subtypes: attenuation of cyclic AMP production in cell lines containing only one receptor subtype.

1989 • 78 citations

Pharmacologic differentiation between pre- and postjunctional α2-adrenoceptors by SK & F 104078

1987 • 71 citations

Desensitization of alpha-1 adrenergic receptor-mediated vascular smooth muscle contraction.

1985 • 69 citations

Stereochemistry and biological activity of drugs

1984 • 69 citations

Molecular cloning, sequencing and expression of an ?2-adrenergic receptor complementary DNA from rat brain

1990 • 68 citations

Stereochemical Studies on Medicinal Agents. IV.¹ Conformational Analysis of Ephedrine Isomers and Related Compounds

1967 • 67 citations

Characterization of α1-adrenoceptors which increase cyclic AMP accumulation in rat cerebral cortex

1986 • 65 citations

Differences in the applicability of the Easson-Stedman hypothesis to the α1- and α2-adrenergic effects of phenethylamines and imidazolines

1983 • 64 citations

Phosphoinositide hydrolysis is correlated with agonist-induced calcium flux and contraction in the rabbit aorta

1985 • 63 citations

Heterogeneity of Postjunctional α<sub>1</sub>-Adrenoceptors in Mammalian Aortae: Subclassification Based on Chlorethylclonidine, WB 4101 and Nifedipine

1992 • 62 citations

Effects of α₂‐adrenoceptor agonists and of related compounds on aggregation of, and on adenylate cyclase activity in, human platelets

1984 • 62 citations

α-Adrenoceptor-effector coupling: affinity states or heterogeneity of the α2-adrenoceptor?

1985 • 61 citations

Ca++ utilization in the constriction of rat aorta to full and partial alpha-1 adrenoceptor agonists.

1986 • 61 citations

3H-Noradrenaline release from rat neocortical slices in the absence of extracellular Ca2+ and its presynaptic alpha2-adrenergic modulation

1983 • 60 citations

Renal effects of selective alpha-1 and alpha-2 adrenoceptor agonists in conscious, normotensive rats.

1987 • 58 citations

Identification of structurally distinct alpha 2-adrenergic receptors.

1988 • 58 citations

Subtypes of .ALPHA.1-Adrenoceptors Involved in Noradrenaline-Induced Contractions of Rat Thoracic Aorta and Dog Carotid Artery.

1991 • 58 citations

Steric aspects of adrenergic drugs. II. Effects of DL isomers and desoxy derivatives on the reserpine-pretreated vas deferens.

1967 • 56 citations

Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity.

1986 • 54 citations

Decreased sensitivity to α₂ adrenergic amines, adenosine and prostaglandins in white fat cells from hamsters treated with pertussis vaccine

1981 • 52 citations

The rat α₂‐C4 adrenergic receptor gene encodes a novel pharmacological subtype

1991 • 51 citations

THE EXISTENCE OF A NEW SUBTYPE OF α‐ADRENOCEPTOR ON THE RAT ANOCOCCYGEUS IS REVEALED BY SGD 101/75 AND PHENOXYBENZAMINE

1982 • 49 citations

Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha2-adrenergic agonists

1983 • 48 citations

The preferred conformation of noradrenaline and a consideration of the α-adrenergic receptor

1969 • 47 citations

The preferred conformations of ephedrine isomers and the nature of the alpha adrenergic receptor.

1968 • 44 citations

Steric aspects of adrenergic drugs. I. Comparative effects of DL isomers and desoxy derivatives.

1967 • 44 citations

Molecular characteristics of biogenic monoamines and their analogs

1973 • 42 citations

Sustained Diacylglycerol Formation in Norepinephrine-Stimulated Rat Heart is Associated with α1-Adrenergic Receptor

1988 • 37 citations

The crystal and molecular structures of ephedrine hydrochloride

1954 • 35 citations

[³H]‐RS‐15385–197, a selective and high affinity radioligand for α₂‐adrenoceptors: implications for receptor classification

1992 • 35 citations

The conformation of catecholamines and related compounds in solution.

1973 • 35 citations

Solubilization and characterization of putative alpha-2 adrenergic isoceptors from the human platelet and the rat cerebral cortex.

1985 • 33 citations

Cloning and expression of the mouse homolog of the human α2-C2 adrenergic receptor

1992 • 33 citations

Heat capacities and thermodynamic properties of Cr3Te4 and Ni3Te4 from 298 to 950 K. Structural order-disorder transitions

1973 • 32 citations

Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]ethyl]-1,4-benzodioxane (WB-4101), a potent competitive .alpha.-adrenergic antagonist

1979 • 31 citations

Differential effect of pertussis toxin on pre- and postjunctional α2-adrenoceptors in the cardiovascular system of the pithed rat

1988 • 31 citations

Aromatic and benzylic hydroxyl substitution of imidazolines and phenethylamines: differences in activity at alpha-1 and alpha-2 adrenergic receptors.

1983 • 31 citations

Receptor interactrions of imidazolines. VI. Significance of carbon bridge separating phenyl and imidazoline rings of tolazoline-like alpha adrenergic imidazolines.

1980 • 31 citations

Steric aspects of adrenergic drugs. IX. Pharmacologic and histochemical studies on isomers of cobefrin (alpha-methylnorepinephrine).

1968 • 30 citations

A difference in the affinity of some selective ?2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit

1985 • 30 citations

Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.

1984 • 29 citations

Conformational analogs of dopamine. Synthesis and pharmacological activity of (E)- and (Z)-2-(3,4-dihydroxyphenyl)cyclopropylamine hydrochlorides

1979 • 29 citations

GTP and Na+ modulate receptor-adenyl cyclase coupling and receptor-mediated function

1984 • 28 citations

Pharmacologic characterization of SK&F 104078, a novel alpha-2 adrenoceptor antagonist which discriminates between pre- and postjunctional alpha-2 adrenoceptors.

1988 • 27 citations

Receptor interactions of imidazolines. II. Affinities and efficacies of hydroxy-substituted tolazoline derivatives in rat aorta.

1979 • 27 citations

Desensitization of the alpha1 adrenoceptor system in vascular smooth muscle

1984 • 25 citations

The Preferred Conformation of Noradrenaline

1971 • 25 citations

Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists

1988 • 24 citations

Lack of a pharmacological distinction between alpha-1 adrenoceptors mediating intracellular calcium-dependent and independent contractions to sympathetic nerve stimulation in the perfused rat caudal artery.

1991 • 23 citations

The molecular conformation of clonidine hydrochloride, an ?-adrenergic agonist

1979 • 22 citations

Inhibition of vasopressin-stimulated cyclic AMP accumulation by alpha-2 adrenoceptor agonists in isolated papillary collecting ducts.

1988 • 22 citations

α₂‐Adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes

1991 • 21 citations

Remarks on chemical specificity

1950 • 21 citations

Blockade of Adrenergic α-Receptors by a Carbonium Ion

1962 • 20 citations

Stereochemical requirements of α2-adrenergic receptors for α-methyl substituted phenethylamines

1982 • 20 citations

Strukturuntersuchungen an 2‐(Arylimino)imidazolidinen und 2‐(Arylamino)imidazolinen mit Hilfe der Protonen‐ und Kohlenstoff‐13‐Resonanz

1974 • 20 citations

The α₂‐adrenoceptors of the human retinoblastoma cell line (Y79) may represent an additional example of the α_2C‐adrenoceptor

1992 • 19 citations

Stereochemical requirements for activation and blockade of α1- and α2- adrenoceptors

1984 • 18 citations

Stereochemical studies on medicinal agents. 10. Role of chirality in .alpha.-adrenergic receptor blockage by (+)- and (-)-phenoxy benzamine hydrochloride

1971 • 17 citations

L-654,284 a new potent and selective ?2-adrenoceptor antagonist

1986 • 17 citations

Alpha adrenoreceptors of rabbit aorta and stomach fundus.

1981 • 16 citations

Ultraviolet photoelectron spectroscopy of cyclic amidines. 2. Electronic structure of clonidine and some related 2-(phenylimino)imidazolidines with .alpha.-adrenergic activity

1980 • 16 citations

Action of stereoisomers of (imidazolinyl-2)-2-benzodioxane-1-4 or 2-(2-(1,4-benzodioxanyl))-2-imidazoline (170 150; RX 781094) on peripheral presynaptic and central α2-adrenoceptors

1982 • 16 citations

Adrenoceptor-mediated effects of optically active catecholimidazolines in pithed rat

1983 • 13 citations

A conformational study of .beta.-phenethanolamine receptor sites. I. The syntheses of the 3-amino-2-phenyl-trans-2-decalols

1968 • 13 citations

Conformational requirements of alpha 2-adrenergic receptors.

1982 • 13 citations

Clonidine base: evidence for conjugation of both ring systems.

1975 • 13 citations

Structure—Activity Relationships for alpha-1 Adrenergic Receptor Agonists and Antagonists

1987 • 12 citations

Predominance ofα2-Adrenoceptors in Porcine Thyroid: Biochemical and Pharmacological Correlations*

1984 • 12 citations

α2-Adrenoceptor agonist properties of exo- and endo-isomers of 2-amino-6,7,dihydroxybenzo-norbornene designed as rigid catecholamines

1983 • 12 citations

Conformation of N-(β-Chloroethyl)-2-phenoxyethylamines in Relation to Adrenergic Blocking Activity¹

1963 • 9 citations

Classification of bovine aortic alpha-1 adrenoceptors by the criteria of ligand affinity and molecular mass.

1988 • 9 citations

Phosphoinositides and alpha-1 Adrenergic Receptors

1987 • 9 citations

Biochemical correlates for the pharmacological effects of L(+)-Isomers and β-desoxy-sympathomimetic amines

1976 • 4 citations

Book Reviews

1985 • 2 citations