Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

1977 • 679 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

Adenyl Cyclase in Fat Cells

1969 • 437 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

1981 • 257 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores.

1979 • 193 citations

Islets-Activating Protein (IAP) in Bordetella pertussis that Potentiates Insulin Secretory Responses of Rats

1978 • 178 citations

The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.

1979 • 171 citations

Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.

1982 • 164 citations

The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.

1981 • 141 citations

The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.

1980 • 126 citations

GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes.

1977 • 120 citations

Biological Properties of Islets-Activating Protein (IAP) Purified from the Culture Medium of Bordetella pertussis

1978 • 117 citations

Guanine Nucleotides: Key Regulators of Hormone Receptor-Adenylate Cyclase Interaction

1981 • 115 citations

Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E1, and guanine nucleotides. Evidence for separate guanine nucleotide sites mediating stimulation and inhibition.

1979 • 108 citations

Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.

1977 • 92 citations

Alpha 2-adrenergic inhibition of insulin secretion via interference with cyclic AMP generation in rat pancreatic islets.

1982 • 90 citations

Neuroblastoma adenylate cyclase. Role of 2-chloroadenosine, prostaglandin E1, and guanine nucleotides in regulation of activity.

1976 • 80 citations

Mechanism of action of choleragen andE. coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation

1981 • 61 citations

Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes.

1981 • 49 citations

Choleragen-stimulated release of guanyl nucleotides from turkey erythrocyte membranes.

1982 • 43 citations

Limited proteolysis eliminates guanine nucleotide inhibition of choleragen-activated adenylate cyclase. Possible basis for proteolytic stimulation of cyclic AMP production.

1980 • 22 citations