Islet-activating protein (pertussis toxin) diminishes ?2-adrenoceptor mediated effects on noradrenaline release

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

1983 • 406 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins

1983 • 309 citations

Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase.

1983 • 268 citations

Bimodal regulation of adenylate cyclase

1982 • 161 citations

Modulation by endogenous dopamine of the release of acetylcholine in the caudate nucleus of the rabbit

1980 • 159 citations

Separation and purification of the hemagglutinins from Bordetella pertussis

1983 • 132 citations

Pharmacological Characterizations of Adrenergic Receptors in Human Adipocytes

1981 • 103 citations

Regulation of adenylate cyclase activity in hamster adipocytes

1980 • 101 citations

Alpha 2-adrenergic inhibition of insulin secretion via interference with cyclic AMP generation in rat pancreatic islets.

1982 • 90 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. IV. An evaluation of a role for cyclic adenosine monophosphate.

1975 • 84 citations

Differential effect of pertussis toxin on the affinity state for agonists of renal alpha 1- and alpha 2- adrenoceptors.

1984 • 79 citations

Agonistic and antagonistic effects of various ?-adrenergic agonists in human platelets

1979 • 78 citations

Intracellular localization of the dermonecrotic toxin of Bordetella pertussis

1979 • 73 citations

Inhibition of adenylate cyclase by hormones and neurotransmitters.

1981 • 73 citations

Alpha 2-adrenergic receptors in neuroblastoma x glioma hybrid cells. Characterization with agonist and antagonist radioligands and relationship to adenylate cyclase.

1982 • 69 citations

Forskolin and the release of noradrenaline in cerebrocortical slices

1984 • 66 citations

Possible role of cyclic nucleotides in regulation of noradrenaline release from rat pineal through presynaptic adrenoceptors

1978 • 64 citations

3H-Noradrenaline release from rat neocortical slices in the absence of extracellular Ca2+ and its presynaptic alpha2-adrenergic modulation

1983 • 60 citations

Islet‐activating protein prevents nicotinic acid‐induced GTPase stimulation and GTP but not GTPγS‐induced adenylate cyclase inhibition in rat adipocytes

1983 • 56 citations

The influence of 8-Br 3?,5?-cyclic nucleotide analogs and of inhibitors of 3?,5?-cyclic nucleotide phosphodiesterase, on noradrenaline secretion and neuromuscular transmission in guinea-pig vas deferens

1979 • 53 citations

Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc⁻ variants are prevented by islet‐activating protein

1983 • 53 citations

Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule

1984 • 52 citations

Decreased sensitivity to α₂ adrenergic amines, adenosine and prostaglandins in white fat cells from hamsters treated with pertussis vaccine

1981 • 52 citations

Islet-activating protein impairs ? 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase

1983 • 47 citations

Identification of mechanisms involved in the modulation of release of noradrenaline in the hippocampus of the rabbit in vitro

1984 • 46 citations

Decrease of Clonidine Binding Affinity to α₂‐Adrenoceptor by ADP‐Ribosylation of 41,000‐Dalton Proteins in Rat Cerebral Cortical Membranes by Islet‐Activating Protein

1985 • 40 citations

Effect of islet-activating protein (IAP) on contractile responses of rat vas deferens: Evidence for participation of Ni(inhibitory GTP binding regulating protein) in the α2-adrenoceptor-mediated response

1983 • 29 citations

Role of dopamine receptors in the modulation of acetylcholine release in the rabbit hippocampus

1982 • 28 citations

Effect of pertussis toxin on α₂‐adrenoceptors: decreased formation of the high‐affinity state for agonists

1984 • 19 citations

Effect of pertussis toxin on the adrenergic regulation of plasma renin activity

1984 • 17 citations

Direct action of pertussis toxin in isolated hamster fat cells

1984 • 12 citations

Effect of pertussis vaccine on α-adrenoceptors of the circulatory system of the rat

1982 • 11 citations