The Hepatitis B Virus X-associated Protein, XAP3, Is a Protein Kinase C-binding Protein

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

1996 • 1,857 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

[10] Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast

1983 • 1,095 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

1996 • 541 citations

Regulation of the Yeast HO Gene

1985 • 526 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos.

1989 • 334 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases

1996 • 283 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains

1994 • 256 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

A cDNA for a Protein That Interacts with the Human Immunodeficiency Virus Tat Transactivator

1990 • 234 citations

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

1987 • 217 citations

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme

1991 • 212 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Hepatitis B virus X‐gene product: A promiscuous transcriptional activator

1992 • 208 citations

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

1992 • 203 citations

E1A 13S and 12S mRNA Products Made in Escherichia coli Both Function as Nucleus-Localized Transcription Activators but Do Not Directly Bind DNA

1985 • 190 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions.

1988 • 176 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA

1986 • 165 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.

1988 • 157 citations

The DNA-Binding Properties of the Major Regulatory Protein α4 of Herpes Simplex Viruses

1988 • 144 citations

Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes.

1984 • 140 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

1996 • 133 citations

Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.

1994 • 122 citations

Interaction cloning of protein kinase C substrates.

1993 • 122 citations

35H, a Sequence Isolated as a Protein Kinase C Binding Protein, Is a Novel Member of the Adducin Family

1995 • 121 citations

Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cMYC protooncogene at the transcriptional level

1991 • 120 citations

XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation

1996 • 120 citations

Identification of three essential regions of hepatitis B virus X protein for trans-activation function.

1992 • 99 citations

Protein kinase C and phosphatidylserine bind to Mr 110,000/115,000 polypeptides enriched in cytoskeletal and postsynaptic density preparations.

1986 • 95 citations

The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

1990 • 94 citations

Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus.

1991 • 81 citations

Hepatitis B Virus HBx Gene and Hepatocarcinogenesis

1995 • 81 citations

Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2

1990 • 77 citations

DNA-binding properties of an adenovirus 289R E1A protein.

1988 • 77 citations

The Hepatitis B Virus X Protein Increases the Cellular Level of TATA-Binding Protein, Which Mediates Transactivation of RNA Polymerase III Genes

1995 • 69 citations

Protein kinase C and tumor promoters

1990 • 69 citations

The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax.

1990 • 65 citations

Evidence for cooperativity between E2 binding sites in E2 trans-regulation of bovine papillomavirus type 1

1988 • 52 citations

Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.

1994 • 52 citations

In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein

1985 • 47 citations

An internal domain of the hepatitis B virus X antigen is necessary for transactivating activity

1991 • 40 citations

trans-Activation by the hepatitis B virus X protein shows cell-type specificity

1989 • 37 citations

Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway

1996 • 33 citations

Protein kinase C--an enzyme and its relatives.

1994 • 31 citations

Three Sites of the Hepatitis B Virus X Protein Cooperatively Interact with Cellular Proteins

1994 • 28 citations

In vitro Transformation by Hepatitis B Virus DNA

1995 • 17 citations