Repression of protein synthesis by miRNAs: how many mechanisms?

MicroRNAs

2004 • 33,206 citations

The functions of animal microRNAs

2004 • 10,392 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Silencing of microRNAs in vivo with ‘antagomirs’

2005 • 3,846 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

2006 • 1,957 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

A brain-specific microRNA regulates dendritic spine development

2006 • 1,746 citations

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

2006 • 1,582 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

2005 • 1,403 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

2006 • 1,285 citations

Ribo-gnome: The Big World of Small RNAs

2005 • 1,276 citations

siRNAs can function as miRNAs

2003 • 1,252 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

MicroRNAs direct rapid deadenylation of mRNA

2006 • 1,114 citations

HuR and mRNA stability

2001 • 1,025 citations

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

2006 • 1,006 citations

A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis

2005 • 979 citations

Molecular mechanisms of translational control

2004 • 967 citations

RNA granules

2006 • 946 citations

Regulation of cap-dependent translation by eIF4E inhibitory proteins

2005 • 944 citations

Perspective: machines for RNAi

2005 • 942 citations

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

2005 • 848 citations

siRNA function in RNAi: A chemical modification analysis

2003 • 837 citations

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

2004 • 831 citations

MicroRNA function in animal development

2005 • 812 citations

The enzymes and control of eukaryotic mRNA turnover

2004 • 793 citations

The cap-to-tail guide to mRNA turnover

2001 • 759 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

Short RNAs Repress Translation after Initiation in Mammalian Cells

2006 • 731 citations

Molecular mechanisms of translation initiation in eukaryotes

2001 • 730 citations

Processing bodies require RNA for assembly and contain nontranslating mRNAs

2005 • 696 citations

MicroRNA function: Multiple mechanisms for a tiny RNA?: FIGURE 1.

2005 • 676 citations

A role for the P-body component GW182 in microRNA function

2005 • 670 citations

Cytoplasmic foci are sites of mRNA decay in human cells

2004 • 644 citations

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

2005 • 642 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

General Translational Repression by Activators of mRNA Decapping

2005 • 630 citations

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

2005 • 629 citations

Kinetic analysis of the RNAi enzyme complex

2004 • 537 citations

Identification of Novel Argonaute-Associated Proteins

2005 • 533 citations

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

2006 • 505 citations

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

2005 • 491 citations

Disruption of GW bodies impairs mammalian RNA interference

2005 • 487 citations

Eukaryotic mRNA Decapping

2004 • 476 citations

RNAi: The Nuts and Bolts of the RISC Machine

2005 • 474 citations

How Do MicroRNAs Regulate Gene Expression?

2007 • 472 citations

Synaptic Protein Synthesis Associated with Memory Is Regulated by the RISC Pathway in Drosophila

2006 • 441 citations

Human let-7a miRNA blocks protein production on actively translating polyribosomes

2006 • 438 citations

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

2002 • 397 citations

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

2004 • 390 citations

Slicer function of Drosophila Argonautes and its involvement in RISC formation

2005 • 389 citations

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

2005 • 389 citations

Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules

2006 • 385 citations

Evidence that microRNAs are associated with translating messenger RNAs in human cells

2006 • 330 citations

The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

2005 • 268 citations

Detecting and Measuring Cotranslational Protein Degradation in Vivo

2000 • 247 citations

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

2006 • 210 citations

Local translational control in dendrites and its role in long‐term synaptic plasticity

2005 • 189 citations

Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro

2006 • 181 citations

Antiapoptotic function of RNA-binding protein HuR effected through prothymosin α

2005 • 160 citations

Genome-Wide Analysis of mRNAs Regulated by Drosha and Argonaute Proteins in Drosophila melanogaster

2006 • 137 citations

Formation of GW bodies is a consequence of microRNA genesis

2006 • 123 citations

Sbp1p Affects Translational Repression and Decapping in Saccharomyces cerevisiae

2006 • 63 citations

Takeover of host ribosomes by divergent IRES elements

2005 • 43 citations