MicroRNA function: Multiple mechanisms for a tiny RNA?: FIGURE 1.

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

2005 • 2,470 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

Mechanisms of gene silencing by double-stranded RNA

2004 • 2,439 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

2001 • 1,430 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

2005 • 1,403 citations

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

2003 • 1,323 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

siRNAs can function as miRNAs

2003 • 1,252 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

MicroRNA Pathways in Flies and Worms

2003 • 1,203 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

A microRNA array reveals extensive regulation of microRNAs during brain development

2003 • 1,034 citations

Perspective: machines for RNAi

2005 • 942 citations

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

2003 • 915 citations

A Cellular MicroRNA Mediates Antiviral Defense in Human Cells

2005 • 906 citations

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

2002 • 874 citations

Induction and Suppression of RNA Silencing by an Animal Virus

2002 • 858 citations

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

2005 • 848 citations

siRNA function in RNAi: A chemical modification analysis

2003 • 837 citations

The enzymes and control of eukaryotic mRNA turnover

2004 • 793 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

Purified Argonaute2 and an siRNA form recombinant human RISC

2005 • 736 citations

Processing bodies require RNA for assembly and contain nontranslating mRNAs

2005 • 696 citations

TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing

2005 • 650 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

2005 • 629 citations

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

2003 • 574 citations

Kinetic analysis of the RNAi enzyme complex

2004 • 537 citations

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

2005 • 537 citations

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

2005 • 518 citations

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

2005 • 491 citations

Eukaryotic mRNA Decapping

2004 • 476 citations

RNAi: The Nuts and Bolts of the RISC Machine

2005 • 474 citations

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

2005 • 421 citations

Assembly and function of RNA silencing complexes

2005 • 412 citations

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

2002 • 397 citations

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

2004 • 390 citations

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

2005 • 389 citations

A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles

2002 • 365 citations

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

2004 • 342 citations

A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

1997 • 341 citations

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

2005 • 337 citations

Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila

2005 • 316 citations

The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

2005 • 268 citations

A New Paradigm for Translational Control: Inhibition via 5′-3′ mRNA Tethering by Bicoid and the eIF4E Cognate 4EHP

2005 • 259 citations

Substrate requirements for let-7 function in the developing zebrafish embryo

2016 • 219 citations

miRNP:mRNA association in polyribosomes in a human neuronal cell line

2004 • 209 citations

Substrate requirements for let-7 function in the developing zebrafish embryo

2004 • 205 citations

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

2004 • 205 citations

Novel modes of protein–RNA recognition in the RNAi pathway

2005 • 92 citations

Tethered-function analysis reveals that eIF4E can recruit ribosomes independent of its binding to the cap structure

2001 • 43 citations