Methotrexate resistance and gene amplification. Mechanisms and implications

Transposition and amplification of oncogene-related sequences in human neuroblastomas

1983 • 711 citations

Constitutive Fragile Sites and Cancer

1984 • 693 citations

Gene amplification in cultured animal cells

1984 • 639 citations

GENE AMPLIFICATION

1984 • 580 citations

A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

1983 • 485 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA

1977 • 479 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster

1980 • 301 citations

Induction of replication by thymine starvation at the chromosome origin in Escherichia coli

1964 • 262 citations

Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization

1984 • 260 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.

1983 • 244 citations

Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts.

1981 • 212 citations

Molecular cloning and expression of the mouse ornithine decarboxylase gene.

1984 • 211 citations

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

1981 • 191 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Resistance to methotrexate due to gene amplification in a patient with acute leukemia.

1984 • 145 citations

The Fragile X Chromosome

1983 • 144 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Gene amplification in a leukemic patient treated with methotrexate.

1984 • 139 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma.

1984 • 123 citations

A trans -Acting Product Needed for P Factor Transposition in Drosophila

1984 • 122 citations

Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes

1981 • 120 citations

Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

1983 • 118 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

Novel amplification and transcriptional activity of chorion genes in Drosophila melanogaster follicle cells

1983 • 112 citations

Advances in Clinical Cytology

1982 • 109 citations

Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting.

1983 • 106 citations

Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.

1981 • 96 citations

Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells

1978 • 93 citations

Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line

1985 • 91 citations

Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase

1980 • 88 citations

Replication of the Bacterial Chromosome: Location of New Initiation Sites After Irradiation

1969 • 75 citations

Selective overproduction of adenosine deaminase in cultured mouse cells.

1983 • 75 citations

Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations.

1985 • 66 citations

Amplification and rearrangement of onc genes in mammalian species

1982 • 56 citations

Tumors as clonal proliferation

1978 • 49 citations

The putative molybdate-stabilized progesterone receptor subunit is not a steroid-binding protein.

1984 • 39 citations

Rapid emergence of methotrexate resistance in cultured mouse cells.

1984 • 39 citations

Amplification of the UMP synthase gene and enzyme overproduction in pyrazofurin-resistant rat hepatoma cells. Molecular cloning of a cDNA for UMP synthase.

1984 • 34 citations

Chromosomes and Cancer in the Mouse: Studies in Tumors, Established Cell Lines, and Cell Hybrids

1983 • 30 citations

Detection of S-phase overreplication following chronic hypoxia using a monoclonal anti-BrdUrd

1985 • 29 citations

Disruption of DNA synthesis in by heat shock

1970 • 27 citations

A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variants.

1984 • 26 citations

Limitations of DNA histogram analysis by flow cytometry as a method of predicting chemosensitivity in a rat renal cancer model.

1983 • 14 citations