Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

Visualization of Nucleolar Genes

1969 • 865 citations

Gene amplification in cultured animal cells

1984 • 639 citations

Metaphase chromosome structure: Evidence for a radial loop model

1979 • 552 citations

Detection of viral sequences of low reiteration frequency by in situ hybridization.

1978 • 458 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization

1984 • 260 citations

Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.

1979 • 252 citations

Arrangement of centromeres in mouse cells

1971 • 222 citations

Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

1977 • 195 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

1982 • 184 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

In situ hybridization at the electron microscope level: hybrid detection by autoradiography and colloidal gold

1982 • 134 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes

1981 • 120 citations

Have double minutes functioning centromeres?

2009 • 117 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.

1981 • 96 citations

Extrachromosomal nucleolar genes in amphibian oocytes.

1969 • 79 citations

Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells

1980 • 72 citations

Nucleosome packing in interphase chromatin.

1979 • 69 citations

Higher order structure in metaphase chromosomes

1978 • 69 citations

Chromatin organization during meiotic prophase ofBombyx mori

1980 • 50 citations

Ultrastructure of double minutes from a human tumor cell line.

1979 • 39 citations

Relationship of Amplified Dihydrofolate Reductase Genes to Double Minute Chromosomes in Unstably Resistant Mouse Fibroblast Cell Lines

1981 • 34 citations

Loss and Stabilization of Amplified Dihydrofolate Reductase Genes in Mouse Sarcoma S-180 Cell Lines

1981 • 28 citations

A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variants.

1984 • 26 citations

Ultrastructural organization of double minute chromosomes and HSR regions in human colon carcinoma cells

1984 • 23 citations