A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variants.

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Characterization of differentiated and dedifferentiated clones from a rat hepatoma

1975 • 381 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.

1964 • 314 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1976 • 237 citations

A QUANTITATIVE COMPARISON OF FORMATION OF SPONTANEOUS AND VIRUS-PRODUCED VIABLE HYBRIDS

1969 • 230 citations

[A new technic of analysis of the human karyotype].

1971 • 218 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts.

1981 • 212 citations

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

1981 • 191 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Dedifferentiated variants of a rat hepatoma: Reversion analysis

1980 • 129 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells.

1982 • 121 citations

Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes

1981 • 120 citations

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

1979 • 118 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

A selective system for hepatoma cells producing gluconeogenic enzymes

1977 • 58 citations

Relationship of Amplified Dihydrofolate Reductase Genes to Double Minute Chromosomes in Unstably Resistant Mouse Fibroblast Cell Lines

1981 • 34 citations

Dedifferentiated variants of a rat hepatoma: Partial reversion induced by cell aggregation

1980 • 28 citations

Chromatin repeat length correlates with phenotypic expression in hepatoma cells, their dedifferentiated variants, and somatic hybrids.

1980 • 25 citations

Cited By (0)

Loading...