Endothelial dysfunction: Clinical implications

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Mortality in relation to smoking: 40 years' observations on male British doctors

1994 • 5,782 citations

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

1992 • 4,765 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

The pathogenesis of coronary artery disease and the acute coronary syndromes (First of two parts)

1992 • 1,958 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.

1993 • 1,542 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women

1994 • 1,326 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

The Effect of Cholesterol-Lowering and Antioxidant Therapy on Endothelium-Dependent Coronary Vasomotion

1995 • 1,123 citations

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

1986 • 1,106 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Induction of calcium-dependent nitric oxide synthases by sex hormones.

1994 • 1,074 citations

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

1996 • 1,066 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

Endothelium-dependent vasodilation is attenuated in patients with heart failure.

1991 • 788 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women

1994 • 708 citations

Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.

1993 • 707 citations

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.

1993 • 685 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.

1990 • 660 citations

Physical Training Improves Endothelial Function in Patients With Chronic Heart Failure

1996 • 638 citations

Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.

1994 • 602 citations

The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress

1991 • 602 citations

Endothelin in human congestive heart failure.

1994 • 598 citations

Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.

1994 • 590 citations

Contribution of endogenous generation of endothelin-1 to basal vascular tone

1994 • 588 citations

Evidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms

1993 • 567 citations

Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus

1992 • 563 citations

Endothelial function in chronic congestive heart failure

1992 • 562 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

1993 • 550 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women.

1994 • 543 citations

Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts

1988 • 540 citations

Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.

1994 • 540 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits.

1986 • 535 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.

1991 • 531 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Imipramine in Patients with Chest Pain Despite Normal Coronary Angiograms

1994 • 505 citations

Long-term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function

1995 • 496 citations

Plasma endothelin in chronic heart failure.

1992 • 494 citations

Elevated plasma endothelin in patients with diabetes mellitus

1990 • 492 citations

Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia

1992 • 475 citations

Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of "angiographically silent" intimal thickening.

1992 • 471 citations

Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients

1993 • 462 citations

ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULES IN HUMAN DISEASE

1994 • 461 citations

Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity.

1992 • 457 citations

Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis

1994 • 457 citations

Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

1995 • 455 citations

Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.

1992 • 452 citations

Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy.

1990 • 444 citations

Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease

1993 • 430 citations

Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 430 citations

Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

1989 • 421 citations

Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients

1991 • 420 citations

Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia

1996 • 411 citations

Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.

1993 • 409 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Metabolism and excretion of nitric oxide in humans. An experimental and clinical study.

1993 • 404 citations

Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure

1992 • 400 citations

Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels.

1993 • 395 citations

Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes.

1987 • 392 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin.

1986 • 371 citations

The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients.

1993 • 369 citations

Alterations in vasomotor tone in congestive heart failure

1982 • 369 citations

Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.

1989 • 368 citations

Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

1989 • 368 citations

Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition.

1984 • 367 citations

Cardiac transplant atherosclerosis.

1987 • 359 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.

1989 • 357 citations

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.

1993 • 357 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Pathophysiological dilemma of syndrome X.

1992 • 355 citations

Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.

1987 • 354 citations

Effect of Intracoronary Serotonin on Coronary Vessels in Patients with Stable Angina and Patients with Variant Angina

1991 • 354 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium

1989 • 346 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

1992 • 343 citations

Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta.

1991 • 340 citations

Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium.

1994 • 338 citations

Flow-dependent coronary artery dilatation in humans.

1989 • 333 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Immunoreactive endothelin in human plasma: Marked elevations in patients in cardiogenic shock

1989 • 330 citations

Mediators produced by the endothelial cell.

1988 • 329 citations

Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease.

1989 • 328 citations

Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis.

1990 • 324 citations

Update on the role of cigarette smoking in coronary artery disease

1981 • 318 citations

EDRF coordinates the behaviour of vascular resistance vessels

1987 • 318 citations

Defective <scp>l</scp> -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients

1996 • 312 citations

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

1987 • 310 citations

Plasma endothelin levels in hypertension and chronic renal failure.

1990 • 302 citations

Increased plasma endothelin-1 in the early hours of acute myocardial infarction

1991 • 298 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation.

1994 • 296 citations

Impairment of endothelium‐dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin‐induced diabetic rats

1989 • 294 citations

Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension.

1993 • 288 citations

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension

1994 • 287 citations

Endothelial Control of Arterial Distensibility Is Impaired in Chronic Heart Failure

1995 • 282 citations

Role of nitric oxide in reactive hyperemia in human forearm vessels.

1994 • 280 citations

Flow-mediated and reflex changes in large peripheral artery tone in humans.

1989 • 280 citations

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans

1993 • 278 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Non-invasive estimate of the mechanical properties of peripheral arteries from ultrasonic and photoplethysmographic measurements

1991 • 268 citations

Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.

1988 • 265 citations

Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis.

1994 • 264 citations

Increased nitric oxide production in heart failure

1994 • 261 citations

Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol

1990 • 260 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

FEATURES OF ENDOTHELIAL DYSFUNCTION IN EARLY DIABETIC NEPHROPATHY

1989 • 251 citations

Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo

1989 • 250 citations

Effect of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension

1993 • 246 citations

Contrasting peripheral short-term and long-term effects of converting enzyme inhibition in patients with congestive heart failure. A double-blind, placebo-controlled trial.

1989 • 246 citations

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

1990 • 244 citations

EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries

1991 • 239 citations

Failure to augment maximal limb blood flow in response to one-leg versus two-leg exercise in patients with severe heart failure.

1986 • 237 citations

Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers.

1994 • 237 citations

Endothelial dysfunction in patients with chest pain and normal coronary arteries.

1992 • 234 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.

1993 • 233 citations

Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors.

1993 • 232 citations

Responses of coronary arteries of cardiac transplant patients to acetylcholine.

1988 • 231 citations

Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.

1992 • 230 citations

Evidence of endothelial dysfunction in coronary resistance vessels in patients with angina pectoris and normal coronary angiograms

1991 • 228 citations

Effect of endothelin-1 in man.

1990 • 225 citations

Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide

1993 • 222 citations

Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

1994 • 219 citations

Cardiac allograft vasculopathy: current concepts, recent developments, and future directions.

1992 • 217 citations

Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor.

1991 • 216 citations

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 • 214 citations

Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines.

1992 • 214 citations

Role of Endogenous Bradykinin in Human Coronary Vasomotor Control

1995 • 207 citations

Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries.

1989 • 204 citations

Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology.

1989 • 202 citations

Dietary fish oil augments nitric oxide production or release in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1993 • 201 citations

CIGARETTE SMOKING INHIBITS PROSTACYCLIN FORMATION

1983 • 196 citations

Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein.

1991 • 194 citations

Endothelin has biological actions at pathophysiological concentrations.

1991 • 191 citations

Heart failure depresses endothelium-dependent responses in canine femoral artery

1989 • 188 citations

Effect of captopril and enalapril on endothelial function in hypertensive patients.

1994 • 186 citations

Endothelial-dependent coronary vasomotor responsiveness in postmenopausal women with and without estrogen replacement therapy

1994 • 185 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Increased platelet deposition on atherosclerotic coronary arteries.

1994 • 175 citations

Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients.

1992 • 175 citations

Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients.

1992 • 173 citations

Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

1994 • 173 citations

Detection of coronary atherosclerosis in young adult hearts using intravascular ultrasound.

1992 • 171 citations

Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure

1994 • 168 citations

Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis

1994 • 167 citations

Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis.

1991 • 166 citations

Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis.

1991 • 165 citations

L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.

1991 • 165 citations

St Cyres lecture. Endothelium in control.

1991 • 164 citations

Enhanced release of endothelium-derived factor(s) by chronic increases in blood flow

1988 • 159 citations

Selective loss of microvascular endothelial function in human hypercholesterolemia.

1994 • 159 citations

Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells.

1994 • 149 citations

Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure.

1994 • 148 citations

Defective endothelium-mediated control of coronary circulation in conscious dogs after heart failure

1994 • 145 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans

1994 • 144 citations

Endothelins—from receptors to medicine

1993 • 143 citations

Early evidence of endothelial vasodilator dysfunction at coronary branch points.

1990 • 140 citations

Enhanced basal nitric oxide production in heart failure: another failed counter-regulatory vasodilator mechanism?

1994 • 139 citations

Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus

1994 • 139 citations

Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology.

1994 • 136 citations

Endothelin is a potent long-lasting vasoconstrictor in men

1989 • 134 citations

Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia.

1991 • 133 citations

Plasma angiotensin-converting enzyme activity and carotid wall thickening.

1994 • 132 citations

Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits

1993 • 129 citations

Relation between Aortic Atherosclerosis and the Use of Cigarettes and Alcohol

1968 • 128 citations

Cigarette smoke extract contracts isolated porcine coronary arteries by superoxide anion-mediated degradation of EDRF

1994 • 128 citations

Characteristics of flow-mediated brachial artery vasodilation in human subjects.

1989 • 128 citations

Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans

1993 • 124 citations

Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries

1989 • 123 citations

Impaired endothelium-dependent vasodilation in patients with essential hypertension: Evidence that the abnormality is not at the muscarinic receptor level

1994 • 121 citations

Large artery function in patients with chronic heart failure. Studies of brachial artery diameter and hemodynamics.

1991 • 117 citations

In vivo EDRF activity influences platelet function

1988 • 116 citations

Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits

1994 • 116 citations

Chest pain with normal coronary anatomy: A review of natural history and possible etiologic factors

1990 • 115 citations

Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease. Endothelial function revisited.

1994 • 112 citations

Endothelium-Dependent Forearm Vasodilation Is Reduced in Normotensive Subjects with Familial History of Hypertension

1992 • 111 citations

Functional improvement precedes structural regression of atherosclerosis.

1994 • 110 citations

Abnormal coronary vasomotion during exercise in patients with normal coronary arteries and reduced coronary flow reserve.

1989 • 108 citations

Local inhibition of converting enzyme and vascular responses to angiotensin and bradykinin in the human forearm.

1989 • 105 citations

Effects of L-arginine on forearm vessels and responses to acetylcholine.

1992 • 105 citations

Inhalation of sidestream cigarette smoke accelerates development of arteriosclerotic plaques.

1993 • 104 citations

Impaired endothelium-dependent cholinergic coronary vasodilation in patients with angina and normal coronary arteriograms

1992 • 103 citations

Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients

1993 • 101 citations

Endothelial cell function in diabetic microangiopathy

1987 • 97 citations

Effect of l-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans

1994 • 95 citations

Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina.

1992 • 94 citations

Modulation of NO and endothelin by chronic increases in blood flow in canine femoral arteries

1992 • 94 citations

Abnormal cardiac pain perception in syndrome X

1994 • 93 citations

Functional significance of intimal thickening as detected by intravascular ultrasound early and late after cardiac transplantation.

1993 • 92 citations

Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients.

1992 • 91 citations

The effect of antihypertensive therapy on responsiveness to local intra-arterial NG-monomethyl-L-arginine in patients with essential hypertension

1994 • 90 citations

Acetylcholine-induced coronary vasoconstriction in young, heavy smokers with normal coronary arteriographic findings

1993 • 89 citations

Cigarette smoke impairs endothelial cell prostacyclin production.

1986 • 89 citations

Modulation of vascular tonus by the endothelium in experimental diabetes

1987 • 88 citations

Enhanced metabolic vasodilation secondary to diuretic therapy in decompensated congestive heart failure secondary to coronary artery disease

1987 • 86 citations

Effect of Chronic Angiotensin-Converting Enzyme Inhibition on Endothelial Function in Patients with Chronic Heart Failure

1995 • 85 citations

Endothelium-dependent pulmonary artery responses in chronic heart failure: Influence of pulmonary hypertension

1993 • 84 citations

Response of human coronary arteries to aggregating platelets: importance of endothelium-derived relaxing factor and prostanoids.

1988 • 84 citations

Putative mechanisms of the impairment of endothelium-dependent relaxation of the aorta with atheromatous plaque in heritable hyperlipidemic rabbits.

1991 • 84 citations

Substance P dilates epicardial coronary arteries and increases coronary blood flow in humans.

1989 • 83 citations

Vasotonic angina: A spectrum of ischemic sysdroms involving function abnormalities of the epicardial and microvascular coronary circulation

1993 • 82 citations

Angina and normal coronary arteries in women: Gynecologic findings

1992 • 82 citations

Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients

1994 • 79 citations

Sex differences in endothelial function in normal and hypercholesterolaemic subjects

1994 • 78 citations

Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: relation to cardiovascular outcome.

1994 • 74 citations

Vascular responsiveness and cation exchange in insulin-dependent diabetes

1991 • 74 citations

Intracoronary thrombus formation causes focal vasoconstriction of epicardial arteries in patients with coronary artery disease.

1991 • 74 citations

Coronary vasodilator reserve after human orthotopic cardiac transplantation.

1988 • 73 citations

Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries

1992 • 72 citations

Vasodilatory capacity of coronary resistance vessels in dilated cardiomyopathy

1994 • 70 citations

Effects of the converting enzyme inhibitor cilazaprilat on endothelium-dependent responses.

1991 • 69 citations

Hemoglobin inhibits endothelium-dependent relaxation to acetylcholine in human coronary arteries in vivo.

1993 • 66 citations

The effect of probucol and vitamin E treatment on the oxidation of low‐density lipoprotein and forearm vascular responses in humans

1994 • 64 citations

Plasma Endothelin Levels and Vascular Effects of Intravenous <scp>l</scp>-Arginine Infusion in Subjects with Uncomplicated Insulin-Dependent Diabetes Mellitus

1994 • 63 citations

Blood Flow Responses to Intra-Arterial Acetylcholine in Man: Effects of Basal Flow and Conduit Vessel Length

1994 • 60 citations

Endothelium-Dependent Vasodilation is Augmented by Angiotensin Converting Enzyme Inhibitors in Healthy Volunteers

1992 • 57 citations

Lack of contribution of nitric oxide to basal vasomotor tone in heart failure

1994 • 57 citations

Effects of inhibition of nitric oxide formation on regional blood flow in experimental myocardial infarction.

1992 • 54 citations

Endothelial dysfunction early after heart transplantation. Assessment with intravascular ultrasound and Doppler.

1992 • 53 citations

Evaluation of arterial compliance-pressure curves. Effect of antihypertensive drugs.

1991 • 53 citations

Expression of nitric oxide synthase by cytokines in vascular smooth muscle cells.

1994 • 51 citations

Interpretation of the acetylcholine test of endothelial cell dysfunction in hypertension

1992 • 50 citations

Flow-mediated arterial dilation is abnormal in congestive heart failure

1993 • 50 citations

Effects of acetylcholine on epicardial coronary arteries after cardiac transplantation without angiographic evidence of fixed graft narrowing

1988 • 47 citations

Impaired coronary dilator responses to substance P and impaired flow-dependent dilator responses in heart transplant patients with graft vasculopathy

1993 • 46 citations

Forearm blood flow responses to a nitric oxide synthase inhibitor in patients with treated essential hypertension

1994 • 38 citations

Endothelium-Dependent and -Independent Vasodilation and Reactive Hyperemia in Healthy Smokers

1992 • 37 citations

Endothelium-derived relaxing factor (EDRF): a defence mechanism against platelet aggregation and vasospasm in human coronary arteries

1989 • 36 citations

Supersensitivity and Endothelium Dependency of Histamine-induced Relaxation in Mesenteric Arteries Isolated from Diabetic Rats

1986 • 35 citations

Substance p for evaluation of coronary endothelial function after cardiac transplantation

1991 • 34 citations

<scp>l</scp>‐Arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells

1990 • 33 citations

Endothelial dysfunction in the development and detection of transplant coronary artery disease.

1992 • 32 citations

Acetylcholine-induced constriction of angiographically normal coronary arteries is not time dependent in transplant recipients

1993 • 30 citations

Local forearm vasodilation with intra-arterial administration of enalaprilat in humans

1991 • 26 citations

Response of conductance and resistance coronary vessels to scalar concentrations of acetylcholine: Assessment with quantitative angiography and intracoronary doppler echography in 29 patients with coronary artery disease

1994 • 20 citations

Vascular relaxation and cyclic guanosine monophosphate in a rat model of high output heart failure

1993 • 18 citations

Southwestern Internal Medicine Conference: Endothelial Dysfunction and Vascular Disease

1994 • 14 citations

Influence of ramipril diacid on the peripheral vascular effects of angiotensin I

1987 • 13 citations

Heterogeneous effects of the endothelium-dependent vasodilators acetylcholine and substance P on the coronary circulation of patients with angiographically normal coronary arteries

1992 • 11 citations