Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor.

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

1983 • 623 citations

Characterization of a coronary vasoconstrictor produced by cultured endothelial cells

1985 • 616 citations

METHODS FOR THE INVESTIGATION OF PERIPHERAL BLOOD FLOW

1963 • 502 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

1985 • 461 citations

Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

1990 • 446 citations

Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens

1977 • 422 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

1981 • 380 citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

1989 • 353 citations

Molecular mechanism of action of the vasoconstrictor peptide endothelin

1988 • 317 citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

1988 • 299 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Anoxia and endothelium‐dependent reactivity of the canine femoral artery.

1983 • 259 citations

Presence of immunoreactive endothelin in human plasma

1989 • 258 citations

Effects of endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats

1988 • 241 citations

Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells

1988 • 241 citations

ENDOTHELIN: AN IMPORTANT FACTOR IN ACUTE RENAL FAILURE?

1988 • 214 citations

Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anaesthetized, spontaneously hypertensive rats

1988 • 199 citations

Hemodynamic and reflex responses to acute and chronic antihypertensive therapy with the calcium entry blocker nifedipine.

1983 • 134 citations

Endothelin produces pulmonary vasoconstriction and systemic vasodilation

1989 • 124 citations

The Discovery, the Present State, and the Future Prospects of Endothelin

1989 • 123 citations

Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover

1989 • 116 citations

Enhanced alpha-adrenoreceptor-mediated vasoconstriction in essential hypertension.

1981 • 106 citations

The vasodilator potency of atrial natriuretic peptide in man.

1987 • 103 citations

Endothelin-1 Releases Eicosanoids from Rabbit Isolated Perfused Kidney and Spleen

1989 • 88 citations

The Possible Role of Endothelin-1 in the Pathogenesis of Coronary Vasospasm

1989 • 85 citations

Does Endothelin-1 Mediate Endothelium-Dependent Contractions During Anoxia?

1989 • 82 citations

Different Mobilization of Calcium in Endothelin-1 -Induced Contractions in Human Arteries and Veins: Effects of Calcium Antagonists

1990 • 74 citations

Pharmacology of Endothelin-1 in Isolated Vessels

1989 • 72 citations

Positive Inotropic and Vasoconstrictive Effects of Endothelin-1 in in vivo and in vitro Experiments

1989 • 69 citations

The Mechanism of Action of Endothelin-1 as Compared with Other Agonists in Vascular Smooth Muscle

1989 • 58 citations

Effects of endothelin on regional hemodynamics in conscious rats

1989 • 56 citations

Endothelin inhibits ex vivo platelet aggregation in the rabbit

1988 • 54 citations

Plasma Noradrenaline Concentration and α-Adrenoceptor-Mediated Vasoconstriction in Normotensive and Hypertensive Man

1981 • 40 citations

Human Vascular Responses to Endothelin-1

1989 • 33 citations

Effect of Endothelin-1 on Arterioles and Venules in vivo

1989 • 28 citations

Effects of Endothelin-1 and Endothelin-3 on Blood Pressure in Conscious Hypertensive Rats

1989 • 13 citations

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