Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Endothelium-dependent vasodilation is attenuated in patients with heart failure.

1991 • 788 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

METHODS FOR THE INVESTIGATION OF PERIPHERAL BLOOD FLOW

1963 • 502 citations

Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy.

1990 • 444 citations

Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure

1992 • 400 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Organic nitrate esters: clinical use and mechanisms of actions.

1991 • 234 citations

Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors.

1993 • 232 citations

Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha

1991 • 200 citations

Partition of Blood Flow to the Cutaneous and Muscular Beds of the Forearm at Rest and during Leg Exercise in Normal Subjects and in Patients with Heart Failure

1969 • 154 citations

Anti-EDRF effect of tumor necrosis factor in isolated, perfused cat carotid arteries

1989 • 123 citations

Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells

1991 • 98 citations

Enhancement of endothelium-dependent vasodilation by low-dose nitroglycerin in patients with congestive heart failure.

1994 • 44 citations

Activation of the L-Arginine-Nitric Oxide Pathway Is Involved in Vascular Hyporeactivity Induced by Endotoxin

1991 • 29 citations

Stimulated Cellular Immune System in Patients with Congestive Heart Failure

1993 • 18 citations

Critical analysis of methods for assessing regional blood flow and their reliability in clinical medicine

1992 • 2 citations