Defective <scp>l</scp> -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

The measurement of volume changes in human limbs

1953 • 1,503 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension

1995 • 730 citations

Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.

1993 • 707 citations

Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

1993 • 550 citations

Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia

1992 • 475 citations

Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens

1977 • 422 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

1992 • 343 citations

Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta.

1991 • 340 citations

Familial aggregation and genetic epidemiology of blood pressure

1990 • 335 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension.

1993 • 288 citations

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension

1994 • 287 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Effect of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension

1993 • 246 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension

1992 • 238 citations

Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats.

1990 • 234 citations

Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension.

1987 • 196 citations

Effect of captopril and enalapril on endothelial function in hypertensive patients.

1994 • 186 citations

L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.

1991 • 165 citations

Prevention of genetic hypertension by early treatment of spontaneously hypertensive rats with the angiotensin converting enzyme inhibitor captopril.

1993 • 135 citations

Atrial natriuretic factor prevents NaCl-sensitive hypertension in spontaneously hypertensive rats.

1990 • 123 citations

Media: lumen ratio in human small resistance arteries is related to forearm minimal vascular resistance.

1995 • 117 citations

Endothelium-Dependent Forearm Vasodilation Is Reduced in Normotensive Subjects with Familial History of Hypertension

1992 • 111 citations

Limited maximal vasodilator capacity of forearm resistance vessels in normotensive young men with a familial predisposition to hypertension.

1982 • 102 citations

Dilator actions of arginine in human peripheral vasculature

1991 • 86 citations

Effect of potassium on vasodilation to acetylcholine in essential hypertension.

1994 • 81 citations

Effect of age on blood pressure and membrane-dependent vascular responses in the rat.

1987 • 81 citations

Family History Studies in Hypertension Research Review of the Literature

1993 • 73 citations

Media

1995 • 55 citations

Vascular responses to ouabain and norepinephrine in low and normal renin hypertension.

1986 • 55 citations