DNA Scission After Focal Brain Ischemia

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

1991 • 741 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress

1992 • 539 citations

Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat.

1993 • 484 citations

Temporal Profile of in situ DNA Fragmentation after Transient Middle Cerebral Artery Occlusion in the Rat

1995 • 477 citations

In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1

1995 • 453 citations

P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion.

1994 • 428 citations

The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age

1988 • 393 citations

Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans.

1976 • 372 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Nonradioactive labeling of oligonucleotides in vitro with the hapten digoxigenin by tailing with terminal transferase

1991 • 322 citations

Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage—Immunohistochemical investigation of dendritic damage

1989 • 303 citations

The frequency and distribution of medium-sized neurons with indented nuclei in the primate and rodent neostriatum

1985 • 296 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Induction of DNA Fragmentation After 10 to 120 Minutes of Focal Cerebral Ischemia in Rats

1995 • 276 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

Texas red, a hydrophilic, red-emitting flourophore for use with flourescein in dual parameter flow microfluorometric and fluorescence microscopic studies

1982 • 270 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Ischemic Stroke and Incomplete Infarction

1996 • 227 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

A Study of Apoptosis in Normal and Pathologic Nervous Tissue After In situ End-Labeling of DNA Strand Breaks

1994 • 205 citations

Morphological and physiological properties of neostriatal neurons: An intracellular horseradish peroxidase study in the rat

1982 • 198 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

Experimental acute thrombotic stroke in baboons.

1986 • 178 citations

Middle cerebral artery occlusion: correlation of computed tomography and angiography with clinical outcome.

1987 • 176 citations

The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat

1995 • 149 citations

Ultrastructure of Golgi-impregnated and gold-toned spiny and aspiny neurons in the monkey neostriatum

1980 • 139 citations

Internucleosomal DNA Cleavage Involved in Ischemia-Induced Neuronal Death

1993 • 139 citations

DNA polymerase I: from crystal structure to function via genetics

1987 • 138 citations

Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys

1995 • 132 citations

Differences in DNA Fragmentation following Transient Cerebral or Decapitation Ischemia in Rats

1995 • 116 citations

In vivo measurement of cytosolic free calcium during cerebral ischemia and reperfusion

1988 • 113 citations

Early Reperfusion in the Anesthetized Baboon Reduces Brain Damage Following Middle Cerebral Artery Occlusion

1997 • 99 citations

Early Endonuclease Activation following Reversible Focal Ischemia in the Rat Brain

1995 • 97 citations

Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice

1995 • 94 citations

Inhibition of Tyrosine Phosphorylation Prevents Delayed Neuronal Death following Cerebral Ischemia

1993 • 88 citations

Tyrosine Phosphorylation of Microtubule‐Associated Protein Kinase After Transient Ischemia in the Gerbil Brain

1992 • 81 citations

τ Phosphorylation in Human, Primate, and Rat Brain: Evidence that a Pool of τ Is Highly Phosphorylated In Vivo and Is Rapidly Dephosphorylated In Vitro

1994 • 71 citations

HSP70 heat shock gene regulation during ischemia.

1993 • 67 citations

Variability in glutathione-dependent detoxication in vivo and its relevance to detoxication of chemical mixtures

1995 • 63 citations

Target cells for the cytotoxic effects of carcinogens in the murine small bowel

1992 • 55 citations

Modulation of NMDA receptor responsiveness by neurotransmitters, drugs and chemical modification

1990 • 51 citations

Vascular supply pattern to rat caudatoputamen and globus pallidus: scanning electronmicroscopic study of vascular endocasts of stroke-prone vessels.

1981 • 50 citations

Adrenergic and Imidazoline Receptor‐Mediated Responses to UK‐14,304‐18 (Brimonidine) in Rabbits and Monkeys

1995 • 45 citations

Influence of anaesthesia and surgery on neutrophil chemotaxis

1981 • 44 citations

Death of neurons in the neonatal rodent and primate globus pallidus occurs by a mechanism of apoptosis

1994 • 43 citations

Postsurgical granulocyte dysfunction: studies in healthy kidney donors.

1977 • 38 citations

Methylene chloride-induced DNA damage: an interspecies comparison

1995 • 38 citations

In situ localisation of single-stranded DNA breaks in nuclei of a subpopulation of cells within regenerating skeletal muscle of the dystrophic mdx mouse

1992 • 37 citations

Effect of Tirilazad Mesylate on Middle Cerebral Artery Occlusion/Reperfusion in Nonhuman Primates

1995 • 32 citations

Polymorphonuclear Leukocyte Behavior in a Nonhuman Primate Focal Ischemia Model

1994 • 32 citations

Lung oxidant injury in a model of lung storage and extended reperfusion.

1994 • 24 citations

Mapping Studies of Two G Protein-Coupled Receptor Genes: An Amino Acid Difference May Confer a Functional Variation Between a Human and Rodent Receptor

1994 • 23 citations

The role of programmed cell death in the toxicity of the mutagens, ethyl methanesulfonate and N-ethyl-N′-nitrosourea, in AHH-1 human lymphoblastoid cells

1994 • 17 citations

The genetic activity of 6-N-hydroxylaminopurine in Aspergillus nidulans

1994 • 10 citations

Immunocytochemical identification of human chorionic gonadotropin. Comparative study of diaminobenzidine and 3-amino, 9-ethylcarbazole, a nonhazardous chromogen.

1979 • 9 citations

Posthoc phosphorylation of proteins derived from ischemic rat hippocampus, striatum and neocortex

1990 • 8 citations

Expression of the excision repair gene, ERCC3 (excision repair cross-complementing), during mouse development

1994 • 8 citations