Peptide-Derived Antagonists of the Urokinase Receptor. Affinity Maturation by Combinatorial Chemistry, Identification of Functional Epitopes, and Inhibitory Effect on Cancer Cell Intravasation

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1991 • 1,319 citations

General method for rapid synthesis of multicomponent peptide mixtures

1991 • 1,122 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

Selection of phage antibodies by binding affinity

1992 • 514 citations

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1991 • 509 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis

1999 • 287 citations

Structure—function relationships in the receptor for urokinase‐type plasminogen activator Comparison to other members of the Ly‐6 family and snake venom α‐neurotoxins

1994 • 252 citations

Characterization of the Cellular Binding Site for the Urokinase-type Plasminogen Activator

1989 • 248 citations

The Receptor for Urokinase-type Plasminogen Activator Is Not Essential for Mouse Development or Fertility

1995 • 230 citations

Affinity Maturation of Human Growth Hormone by Monovalent Phage Display

1993 • 227 citations

Cell‐induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH₂‐terminal domain of the urokinase receptor

1991 • 194 citations

Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins

1993 • 130 citations

Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract.

1991 • 110 citations

The Murine Receptor for Urokinase-Type Plasminogen Activator Is Primarily Expressed in Tissues Actively Undergoing Remodeling

2001 • 108 citations

Mapping Part of the Functional Epitope for Ligand Binding on the Receptor for Urokinase-type Plasminogen Activator by Site-directed Mutagenesis

1999 • 77 citations

Systematic Mutational Analysis of the Receptor‐Binding Region of the Human Urokinase‐Type Plasminogen Activator

1996 • 75 citations

Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design 1 1Edited by A. Fersht

2000 • 71 citations

Glycosylation Profile of a Recombinant Urokinase-type Plasminogen Activator Receptor Expressed in Chinese Hamster Ovary Cells

1998 • 68 citations

Functional Analysis of the Cellular Receptor for Urokinase in Plasminogen Activation

1996 • 59 citations

Expression of uPA and its receptor by both neoplastic and stromal cells during xenograft invasion

1994 • 58 citations

Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts

1994 • 41 citations

Effect of purified, soluble urokinase receptor on the plasminogen‐prourokinase activation system

1996 • 19 citations

Synthesis and Screening of an Indexed Motif-Library Containing Non-proteinogenic Amino Acids

1997 • 11 citations