Cooperative dimerization of paired class homeo domains on DNA.

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition

1992 • 1,411 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors

1989 • 468 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

Pax in development

1992 • 402 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

What determines the specificity of action of Drosophila homeodomain proteins?

1990 • 357 citations

Organizer-Specific Homeobox Genes in Xenopus laevis Embryos

1991 • 349 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.

1990 • 326 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos

1989 • 316 citations

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

1992 • 314 citations

The POU domain is a bipartite DNA-binding structure

1988 • 304 citations

Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells

1989 • 291 citations

vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1.

1991 • 276 citations

The molecular basis of the undulated/Pax-1 mutation

1991 • 273 citations

The DNA binding specificity of the bipartite POU domain and its subdomains.

1992 • 268 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Functional dissection of ultrabithorax proteins in D. melanogaster

1990 • 255 citations

A novel class of plant proteins containing a homeodomain with a closely linked leucine zipper motif.

1991 • 253 citations

Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein

1990 • 229 citations

Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

1990 • 227 citations

Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein

1991 • 225 citations

Activation and repression of transcription by homoeodomain-containing proteins that bind a common site

1988 • 217 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

A Genetic Model for Interaction of the Homeodomain Recognition Helix with DNA

1991 • 216 citations

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

1987 • 213 citations

POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.

1991 • 199 citations

DNA binding properties of the purified Antennapedia homeodomain.

1990 • 193 citations

The specificities of sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain

1990 • 189 citations

Allosteric underwinding of DNA is a critical step in positive control of transcription by Hg-MerR

1992 • 187 citations

Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.

1991 • 184 citations

Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene

1992 • 179 citations

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons

1992 • 177 citations

A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer

1992 • 170 citations

Determinants of Binding-Site Specificity Among Yeast C ₆ Zinc Cluster Proteins

1993 • 165 citations

The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs

1991 • 164 citations

In vitro genetics

1992 • 159 citations

Differential DNA sequence recognition is a determinant of specificity in homeotic gene action.

1992 • 146 citations

A homeodomain substitution changes the regulatory specificity of the Deformed protein in drosophila embryos

1989 • 142 citations

The interaction with DNA of wild-type and mutant fushi tarazu homeodomains.

1990 • 142 citations

Transmission of allosteric effects in DNA

1979 • 137 citations

A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

1992 • 134 citations

The Oct-2 protein binds cooperatively to adjacent octamer sites.

1989 • 132 citations

Binding of yeast al and α2 as a heterodimer to the operator DNA of a haploid-specific gene

1990 • 132 citations

Altered Specificity of DNA-Binding Proteins with Transition Metal Dimerization Domains

1993 • 128 citations

A comprehensive classification of homeobox genes

1994 • 124 citations

The homeodomain: A new face for the helix‐turn‐helix?

1992 • 120 citations

Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade

1993 • 116 citations

Recognition of the surface of a homeo domain protein.

1992 • 115 citations

Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription

1992 • 113 citations

Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos.

1992 • 104 citations

Mutations That Define the Optimal Half-Site for Binding Yeast GCN4 Activator Protein and Identify an ATF/CREB-Like Repressor That Recognizes Similar DNA Sites

1990 • 100 citations

Structural aspects of protein-DNA recognition

1991 • 96 citations

DNA-binding specificity of the fushi tarazu homeodomain.

1991 • 90 citations

Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes

1993 • 84 citations

Spatial and temporal control elements of the Drosophila engrailed gene.

1990 • 72 citations

Evolutionary Conservation of Homeodomain-Binding Sites and Other Sequences Upstream and within the Major Transcription Unit of the Drosophila Segmentation Gene engrailed

1989 • 54 citations

Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo.

1993 • 54 citations

Functional dissection of the paired segmentation gene in Drosophila embryos.

1991 • 49 citations

In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster.

1992 • 48 citations

The DNA binding specificity of the Drosophila fushi tarazu protein: a possible role for DNA bending in homeodomain recognition.

1990 • 19 citations