Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Prediction of protein conformation

1974 • 3,327 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

The molecular basis for metameric pattern in the Drosophila embryo

1987 • 1,028 citations

The structure and function of the homeodomain

1989 • 1,007 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

New type of POU domain in germ line-specific protein Oct-4

1990 • 753 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1990 • 745 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

1989 • 661 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

The unc-86 gene product couples cell lineage and cell identity in C. elegans

1990 • 606 citations

Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer

1989 • 508 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Globin gene regulation and switching: Circa 1990

1990 • 463 citations

POU-domain transcription factors: pou-er-ful developmental regulators.

1991 • 461 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex

1988 • 442 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins

1990 • 407 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

1991 • 395 citations

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein

1990 • 387 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

1991 • 334 citations

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

1988 • 334 citations

Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript

1990 • 333 citations

The POU domain is a bipartite DNA-binding structure

1988 • 304 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.

1988 • 271 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

Expression and Activity of the POU Transcription Factor SCIP

1990 • 244 citations

Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.

1990 • 238 citations

Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP

1989 • 237 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

Regulation of transcription and cell identity by POU domain proteins

1991 • 233 citations

Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection

1989 • 233 citations

Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

1990 • 227 citations

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

1987 • 217 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation

1991 • 212 citations

POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.

1991 • 199 citations

Caenorhabditis elegans has scores of homoeobox-containing genes

1989 • 197 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons

1990 • 170 citations

The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication.

1990 • 149 citations

Alternative RNA products from the Ultrabithorax domain of the bithorax complex.

1988 • 135 citations

The Oct-2 protein binds cooperatively to adjacent octamer sites.

1989 • 132 citations

Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.

1991 • 127 citations

Mechanisms for diversity in gene expression patterns

1991 • 114 citations

DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation.

1989 • 104 citations

A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.

1990 • 78 citations

Oct-3 is a maternal factor required for the first mouse embryonic division

1991 • 64 citations

Developmentally regulated alternative splicing of transcripts from the Drosophila homeotic gene Antennapedia can produce four different proteins.

1988 • 53 citations

Rapid and efficient site-specific mutagenesis

1990 • 45 citations

Expression of the prokaryotic gene for chloramphenicol acetyl transferase in Drosophila under the control of larval serum protein 1 gene promoters

1986 • 37 citations

Different forms of Ultrabithorax proteins generated by alternative splicing are functionally equivalent.

1990 • 26 citations