Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo.

Homeobox genes and axial patterning

1992 • 2,688 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

Expression of engrailed proteins in arthropods, annelids, and chordates

1989 • 1,019 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

GAL4 activates transcription in Drosophila

1988 • 521 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Characterization and localization of the even-skipped protein of Drosophila.

1987 • 496 citations

Parasegments and compartments in the Drosophila embryo

1985 • 492 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors

1989 • 468 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

Control elements of the Drosophila segmentation gene fushi tarazu

1985 • 404 citations

Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia

1987 • 391 citations

Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development

1984 • 369 citations

Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres

1988 • 366 citations

What determines the specificity of action of Drosophila homeodomain proteins?

1990 • 357 citations

Localization of the fushi tarazu protein during Drosophila embryogenesis

1985 • 290 citations

Modular structure of transcription factors: Implications for gene regulation

1991 • 260 citations

Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster

1984 • 259 citations

Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo.

1989 • 257 citations

Functional dissection of ultrabithorax proteins in D. melanogaster

1990 • 255 citations

Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm

1986 • 242 citations

Boundaries and fields in early embryos

1992 • 239 citations

Autoregulation of a drosophila homeotic selector gene

1988 • 229 citations

Isolation and sequence-specific DNA binding of the Antennapedia homeodomain.

1988 • 221 citations

A Genetic Model for Interaction of the Homeodomain Recognition Helix with DNA

1991 • 216 citations

DNA binding properties of the purified Antennapedia homeodomain.

1990 • 193 citations

The specificities of sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain

1990 • 189 citations

Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.

1991 • 184 citations

Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene

1992 • 179 citations

The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products

1990 • 178 citations

A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer

1992 • 170 citations

Determination of the embryonic axes of Drosophila.

1991 • 160 citations

Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development.

1992 • 156 citations

Near-reciprocal phenotypes caused by inactivation or indiscriminate expression of the Drosophila segmentation gene ftz

1985 • 147 citations

The interaction with DNA of wild-type and mutant fushi tarazu homeodomains.

1990 • 142 citations

A homeodomain substitution changes the regulatory specificity of the Deformed protein in drosophila embryos

1989 • 142 citations

Mapping functional specificity in the Dfd and Ubx homeo domains.

1992 • 134 citations

The homeobox in perspective

1992 • 133 citations

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 • 125 citations

Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated.

1990 • 118 citations

Homeodomain proteins and the regulation of gene expression

1990 • 109 citations

Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos.

1992 • 104 citations

Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos

1992 • 96 citations

DNA-binding specificity of the fushi tarazu homeodomain.

1991 • 90 citations

In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster.

1992 • 48 citations

A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.

1990 • 48 citations

DNA-Binding Specificity of the fushi tarazu Homeodomain†

1991 • 40 citations