A single amino acid can determine the DNA binding specificity of homeodomain proteins

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

The structure and function of the homeodomain

1989 • 1,007 citations

A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoans

1984 • 920 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Crystal structure of trp represser/operator complex at atomic resolution

1988 • 899 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.

1984 • 776 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

1988 • 736 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Determination of Anteroposterior Polarity in Drosophila

1987 • 651 citations

Viral myb oncogene encodes a sequence-specific DNA-binding activity

1988 • 608 citations

Genetic Switch

2008 • 590 citations

Genetic Control of Wing Disc Development in Drosophila

1975 • 584 citations

Recognition of a DNA Operator by the Repressor of Phage 434: A View at High Resolution

1988 • 531 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity

1985 • 387 citations

Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo box

1986 • 380 citations

Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

1987 • 370 citations

Structure of the represser–operator complex of bacteriophage 434

1987 • 365 citations

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1989 • 353 citations

Yeast HAP1 activator binds to two upstream activation sites of different sequence

1987 • 317 citations

Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos

1989 • 316 citations

Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development

1988 • 304 citations

Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells

1989 • 291 citations

Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila

1988 • 289 citations

The segmentation and homeotic gene network in early Drosophila development

1987 • 286 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

Isolation and sequence-specific DNA binding of the Antennapedia homeodomain.

1988 • 221 citations

A multigene family encoding several “finger” structures is present and differentially active in mammalian genomes

1987 • 197 citations

Structure of a phage 434 Cro/DNA complex

1988 • 195 citations

Changing the binding specificity of a represser by redesigning an α-helix

1985 • 176 citations

An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters

1988 • 166 citations

Spatial Programming of Gene Expression in Early Drosophila Embryogenesis

1986 • 157 citations

Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif.

1988 • 151 citations

The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters

1989 • 146 citations

Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells

1989 • 129 citations

A new-specificity mutant of 434 repressor that defines an amino acid–base pair contact

1987 • 119 citations

Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos.

1988 • 116 citations

Bacteriophage lambda int protein recognizes two classes of sequence in the phage att site: characterization of arm-type sites.

1982 • 113 citations

Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2

1988 • 113 citations

Do multigene families regulate vertebrate development?

1988 • 109 citations

DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context.

1988 • 96 citations

How λ repressor and λ Cro distinguish between OR1 and OR3

1986 • 90 citations

Transcripts encoded by a homoeo box gene are restricted to dorsal tissues of Drosophila embryos

1986 • 87 citations

Homologous interactions of λ repressor and λ Cro with the λ operator

1986 • 85 citations

Mutant Trp Repressors with New DNA-Binding Specificities

1988 • 69 citations

Cassettes of the fl intergenic region

1989 • 21 citations

In vitromethylations doubles the efficiency of oligonucleotide-directed mutagenesis

1986 • 7 citations