Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Separation of DNA Binding from the Transcription-Activating Function of a Eukaryotic Regulatory Protein

1986 • 626 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Activators and targets

1990 • 582 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain

1989 • 490 citations

Interaction of a Liver-Specific Nuclear Factor with the Fibrinogen and α ₁ -Antitrypsin Promoters

1987 • 485 citations

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1990 • 450 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

A mediator required for activation of RNA polymerase II transcription in vitro

1991 • 383 citations

Characterization of differentiated and dedifferentiated clones from a rat hepatoma

1975 • 381 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Transcriptional regulation by dimerization: Two sides to an incestuous relationship

1990 • 343 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Purification of nuclear factor I by DNA recognition site affinity chromatography.

1986 • 331 citations

The Role of Cis-Acting Promoter Elements in Tissue-Specific Albumin Gene Expression

1989 • 329 citations

Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.

1988 • 323 citations

Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors

1990 • 312 citations

HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.

1991 • 307 citations

A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.

1988 • 307 citations

An amino-terminal fragment of GAL4 binds DNA as a dimer

1989 • 296 citations

HNF-1, a member of a novel class of dimerizing homeodomain proteins.

1991 • 286 citations

vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1.

1991 • 276 citations

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

1990 • 264 citations

Dissection of functional domains of the pituitary-specific transcription factor GHF-1

1989 • 252 citations

Two distinct factors interact with the promoter regions of several liver-specific genes.

1988 • 226 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.

1991 • 199 citations

Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro.

1989 • 187 citations

LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.

1991 • 171 citations

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1

1990 • 157 citations

The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.

1989 • 148 citations

A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1.

1988 • 139 citations

A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain

1990 • 133 citations

Dedifferentiated variants of a rat hepatoma: Reversion analysis

1980 • 129 citations

Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1.

1990 • 117 citations

An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.

1990 • 108 citations

Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse

1990 • 71 citations