Mutations That Define the Optimal Half-Site for Binding Yeast GCN4 Activator Protein and Identify an ATF/CREB-Like Repressor That Recognizes Similar DNA Sites

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements

1987 • 637 citations

Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast.

1985 • 526 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

Evidence for translational regulation of the activator of general amino acid control in yeast.

1984 • 472 citations

Saccharomyces cerevisiae GAL1-GAL10 Divergent Promoter Region: Location and Function of the Upstream Activating Sequence UAS_G

1984 • 395 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

Saturation Mutagenesis of the Yeast his3 Regulatory Site: Requirements for Transcriptional Induction and for Binding by GCN4 Activator Protein

1986 • 352 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

Defining the Sequence Specificity of DNA-Binding Proteins by Selecting Binding Sites from Random-Sequence Oligonucleotides: Analysis of Yeast GCN4 Protein

1989 • 333 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences.

1986 • 320 citations

Nucleotide sequence and transcriptional mapping of the yeastpet56-his3-dedlgene region

1985 • 290 citations

Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.

1990 • 281 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

1987 • 279 citations

The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous

1987 • 260 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

5' untranslated sequences are required for the translational control of a yeast regulatory gene.

1984 • 257 citations

A perfectly symmetric lac operator binds the lac repressor very tightly.

1983 • 256 citations

A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.

1989 • 239 citations

Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP

1989 • 237 citations

Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein.

1988 • 236 citations

MATα1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes

1987 • 236 citations

Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG.

1984 • 209 citations

Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein.

1989 • 207 citations

Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms.

1986 • 181 citations

Cloning of random-sequence oligodeoxynucleotides

1986 • 162 citations

The interaction of the recognition helix of lac repressor with lac operator.

1987 • 151 citations

Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free.

1988 • 150 citations

Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair.

1984 • 129 citations

DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor.

1988 • 128 citations

Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping "leucine zippers"

1989 • 90 citations

DNA specificity determinants of Escherichia coli tryptophan repressor binding.

1987 • 87 citations

Mammalian cAMP-responsive element can activate transcription in yeast and binds a yeast factor(s) that resembles the mammalian transcription factor ANF.

1989 • 58 citations

Identification and purification of a Saccharomyces cerevisiae protein with the DNA binding specificity of mammalian activating transcription factor.

1989 • 47 citations

Two related regulatory sequences are required for maximal induction of Saccharomyces cerevisiae his3 transcription.

1987 • 37 citations

DNA sequence determinants of lambda repressor binding in vivo.

1988 • 34 citations

Contacts between gamma delta resolvase and the gamma delta res site.

1987 • 25 citations

Phage lambda Cro protein and cI repressor use two different patterns of specific protein-DNA interactions to achieve sequence specificity in vivo.

1989 • 20 citations

Sequence-specific Binding of Arc Repressor to DNA

1989 • 17 citations