Permeability Studies on In Vitro Blood–Brain Barrier Models: Physiology, Pathology, and Pharmacology

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

2003 • 1,705 citations

Tight junctions of the blood–brain barrier

2002 • 1,108 citations

Astrocyte–endothelial interactions and blood–brain barrier permeability*

2002 • 1,098 citations

Methods in molecular medicine.

1987 • 1,096 citations

THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER

1999 • 988 citations

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

2001 • 917 citations

Inflammatory mediators and modulation of blood-brain barrier permeability.

2000 • 769 citations

A cell culture model of the blood-brain barrier.

1991 • 753 citations

The influence of cytokines on the integrity of the blood-brain barrier in vitro

1996 • 641 citations

An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

1990 • 534 citations

A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

1997 • 531 citations

REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS

1998 • 526 citations

Interaction between flavonoids and the blood–brain barrier: in vitro studies

2003 • 517 citations

In Vitro Studies

1992 • 502 citations

Electrical resistance of brain microvascular endothelium

1982 • 478 citations

SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier

2003 • 458 citations

Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation

2005 • 433 citations

Drug and gene targeting to the brain with molecular trojan horses

2002 • 430 citations

γ-Glutamyl Transpeptidase in Isolated Brain Endothelial Cells: Induction by Glial Cells in Vitro

1980 • 404 citations

Tight junctions of brain endothelium in vitro are enhanced by astroglia

1987 • 389 citations

Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation

2002 • 375 citations

Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier

1999 • 365 citations

Modulation of tight junction structure in blood-brain barrier endothelial cells Effects of tissue culture, second messengers and cocultured astrocytes

1994 • 361 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

Functional involvement of P-glycoprotein in blood-brain barrier.

1992 • 352 citations

In vitro model for evaluating drug transport across the blood–brain barrier

1999 • 349 citations

Establishment and functional characterization of an in vitro model of the blood–brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes

2001 • 323 citations

Glial cell influence on the human blood‐brain barrier

2001 • 322 citations

Brain microvessel endothelial cells in tissue culture: A model for study of blood‐brain barrier permeability

1983 • 320 citations

Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier

1992 • 319 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

In Search of the Astrocytic Factor(s) Modulating Blood–Brain Barrier Functions in Brain Capillary Endothelial Cells In Vitro

2005 • 292 citations

Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models

1992 • 289 citations

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

2001 • 274 citations

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

2001 • 274 citations

Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells

2001 • 272 citations

Human Immunodeficiency Virus Type 1 Enters Brain Microvascular Endothelia by Macropinocytosis Dependent on Lipid Rafts and the Mitogen-Activated Protein Kinase Signaling Pathway

2002 • 270 citations

Induction of Astrocyte Differentiation by Endothelial Cells

2001 • 259 citations

Hydrocortisone Reinforces the Blood–Brain Barrier Properties in a Serum Free Cell Culture System

1998 • 252 citations

Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood–brain barrier model for drug uptake and transport studies

2003 • 247 citations

Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

1986 • 246 citations

Functional analysis of tight junctions

2003 • 243 citations

Glial Cell Line-Derived Neurotrophic Factor Induces Barrier Function of Endothelial Cells Forming the Blood–Brain Barrier

1999 • 242 citations

Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO

1999 • 239 citations

Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endothelium

2001 • 234 citations

Primary culture of capillary endothelium from rat brain

1981 • 234 citations

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

1998 • 232 citations

The Role of Drug Transporters at the Blood-Brain Barrier

2003 • 231 citations

Induction of blood–brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors

1999 • 223 citations

Secretion of interleukin‐1β by astrocytes mediates endothelin‐1 and tumour necrosis factor‐α effects on human brain microvascular endothelial cell permeability

2003 • 214 citations

High transcytosis of melanotransferrin (P97) across the blood–brain barrier

2002 • 209 citations

β-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1

2000 • 209 citations

Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells.

2001 • 197 citations

TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.

1997 • 188 citations

Critical Evaluation of ECV304 as a Human Endothelial Cell Model Defined by Genetic Analysis and Functional Responses: A Comparison with the Human Bladder Cancer Derived Epithelial Cell Line T24/83

2000 • 185 citations

A procedure for the isolation of capillaries from rat brain.

1973 • 180 citations

Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier.

1999 • 178 citations

Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells

2003 • 176 citations

An improved low-permeability in vitro-model of the blood–brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol

1999 • 175 citations

Basement Membrane Proteins Influence Brain Capillary Endothelial Barrier Function In Vitro

1998 • 175 citations

Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 1)

2001 • 173 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Relationship between permeability status of the blood–brain barrier and in vitro permeability coefficient of a drug

2000 • 169 citations

A new dynamic in vitro model for the multidimensional study of astrocyte–endothelial cell interactions at the blood–brain barrier

2002 • 165 citations

Neutrophil-derived Glutamate Regulates Vascular Endothelial Barrier Function

2002 • 165 citations

Rat Brain Endothelial Cell Lines for the Study of Blood–Brain Barrier Permeability and Transport Functions

2005 • 165 citations

Carrier-mediated or specialized transport of drugs across the blood–brain barrier

1999 • 164 citations

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

2002 • 164 citations

Pneumolysin Is the Main Inducer of Cytotoxicity to Brain Microvascular Endothelial Cells Caused by Streptococcus pneumoniae

2001 • 163 citations

TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier

1997 • 163 citations

Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor

2003 • 162 citations

Citrobacter freundii Invades and Replicates in Human Brain Microvascular Endothelial Cells

1999 • 161 citations

Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier

1996 • 161 citations

Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells

1992 • 161 citations

The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain

1985 • 158 citations

SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics

1996 • 155 citations

Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders

1999 • 153 citations

Exposure of tumor necrosis factor‐α to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin

1995 • 153 citations

Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier

1997 • 144 citations

The Cerebral Microvessels in Culture, an Update

1992 • 144 citations

Advances in Neurology, Vol. 63

1994 • 140 citations

Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.

1988 • 139 citations

Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts

2004 • 138 citations

Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.

1999 • 138 citations

Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-α exposure

1999 • 136 citations

Traversal of Candida albicans across Human Blood-Brain Barrier In Vitro

2001 • 133 citations

Expression of glutamate receptors on cultured cerebral endothelial cells

1998 • 130 citations

Electrical resistance and macromolecular permeability of brain endothelial monolayer cultures

1987 • 129 citations

An Overview of In Vitro Techniques for Blood-Brain Barrier Studies

2003 • 128 citations

Neural induction of the blood-brain barrier: still an enigma.

2000 • 124 citations

Characteristics of the Large Neutral Amino Acid Transport System of Bovine Brain Microvessel Endothelial Cell Monolayers

1986 • 122 citations

In vitro effects of dexamethasone on hypoxia-induced hyperpermeability and expression of vascular endothelial growth factor

2001 • 122 citations

PHENOTYPIC CHARACTERIZATION OF HUMAN UMBILICAL VEIN ENDOTHELIAL (ECV304) AND URINARY CARCINOMA (T24) CELLS: ENDOTHELIAL VERSUS EPITHELIAL FEATURES

2001 • 121 citations

Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood–brain barrier endothelial cells

2000 • 121 citations

Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

1996 • 117 citations

A co-culture-based model of human blood–brain barrier: application to active transport of indinavir and in vivo–in vitro correlation

2002 • 115 citations

Hypoxia Increases the Susceptibility to Oxidant Stress and the Permeability of the Blood‐Brain Barrier Endothelial Cell Monolayer

1995 • 113 citations

Blood to Brain and Brain to Blood Passage of Native Horseradish Peroxidase, Wheat Germ Agglutinin, and Albumin: Pharmacokinetic and Morphological Assessments

1994 • 111 citations

Heparin Oligosaccharides that Pass the Blood‐Brain Barrier Inhibit β‐Amyloid Precursor Protein Secretion and Heparin Binding to β‐Amyloid Peptide

1998 • 108 citations

Detection of Endogenous Biotin-Containing Proteins in Bone and Cartilage Cells with Streptavidin Systems

1998 • 106 citations

F-Actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors

1997 • 103 citations

Induction of Blood‐Brain Barrier Characteristics in Bovine Brain Endothelial Cells by Rat Astroglial Cells in Transfilter Coculture^a

1991 • 102 citations

Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: influence of astrocyte contact

1999 • 100 citations

P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells

1999 • 100 citations

Electromagnetic fields (1.8 GHz) increase the permeability to sucrose of the blood-brain barrier in vitro

2000 • 100 citations

GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC1Portions of this work were presented at the annual meeting of the Federation of the American Societies of Experimental Biology, April 17–21, 1999, Washington, DC [FASEB J. 13(4), 571.4A (1999)].1

2000 • 99 citations

Evidence for the presence of viable endothelial cells in cultures derived from dissociated rat brain

1978 • 98 citations

Hypoxia Dramatically Increases the Nonspecific Transport of Blood‐Borne Proteins to the Brain

1997 • 95 citations

Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.

1998 • 94 citations

Holey barrier

2003 • 94 citations

Compartmentalized coculture of rat brain endothelial cells and astrocytes: a syngenic model to study the blood–brain barrier

2002 • 94 citations

Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier

1999 • 93 citations

Nitric oxide protects blood‐brain barrier in vitro from hypoxia/reoxygenation‐mediated injury

1998 • 93 citations

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFκB

2003 • 92 citations

The blood-brain barrier in vitro: The second decade

1993 • 92 citations

Adrenomedullin regulates blood–brain barrier functions in vitro

2001 • 91 citations

Permeability and mechanism of albumin, cationized albumin, and glycosylated albumin transcellular transport across monolayers of cultured bovine brain capillary endothelial cells.

1989 • 90 citations

Conditionally Immortalized Cell Lines as a New In Vitro Model for the Study of Barrier Functions

2001 • 87 citations

Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro.

1996 • 85 citations

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

2000 • 84 citations

Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions

1996 • 83 citations

Upregulation of intercellular adhesion molecule-1 expression on human endothelial cells by tumour necrosis factor-α in an in vitro model of the blood–brain barrier

1999 • 82 citations

Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood–brain barrier in vitro

2003 • 82 citations

Effects of transient loss of shear stress on blood–brain barrier endothelium: role of nitric oxide and IL-6

2003 • 79 citations

HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P

1998 • 79 citations

Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia

2002 • 79 citations

Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.

1998 • 77 citations

Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells

2003 • 76 citations

Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood–brain barrier

2002 • 75 citations

Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP

2003 • 74 citations

Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells

2000 • 74 citations

Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro

2003 • 74 citations

Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 2)

2001 • 74 citations

4-Hydroxynonenal impairs the permeability of an in vitro rat blood–brain barrier

2001 • 72 citations

Cell-cell contacts in the human cell line ECV304 exhibit both endothelial and epithelial characteristics

1999 • 71 citations

Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium

2002 • 71 citations

Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene

2000 • 71 citations

Astroglial cells inhibit the increasing permeability of brain endothelial cell monolayer following hypoxia/reoxygenation

1996 • 70 citations

Interactions between Brain Endothelial Cells and Human T-Cell Leukemia Virus Type 1-Infected Lymphocytes: Mechanisms of Viral Entry into the Central Nervous System

2000 • 70 citations

A new model of the blood–brain barrier

1999 • 70 citations

Hypothermia abolishes hypoxia-induced hyperpermeability in brain microvessel endothelial cells

1999 • 65 citations

Functional feature of a novel model of blood brain barrier: studies on permeation of test compounds

2001 • 64 citations

Blood–Brain Barrier Permeability Using Tracers and Immunohistochemistry

2003 • 62 citations

Blood-brain barrier alterations in bacterial meningitis: Development of an in vitro model and observations on the effects of lipopolysaccharide

1991 • 62 citations

Effect of cyclosporin A or tacrolimus on the function of blood–brain barrier cells

1999 • 62 citations

Anin vitroblood–brain barrier model: Cocultures between endothelial cells and organotypic brain slice cultures

1998 • 61 citations

Protective effect of glial cells against lipopolysaccharide‐mediated blood‐brain barrier injury

2003 • 60 citations

A comparison of the induction of immortalized endothelial cell impermeability by astrocytes

2001 • 56 citations

Neoplastic and pharmacological influence on the permeability of an in vitro blood-brain barrier

1995 • 56 citations

Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood−brain barrier

2002 • 56 citations

In vitro blood–brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

2002 • 55 citations

THE INFLUENCE OF OXYGEN FREE RADICALS ON THE PERMEABILITY OF THE MONOLAYER OF CULTURED BRAIN ENDOTHELIAL CELLS

1996 • 54 citations

Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature

2004 • 54 citations

HIV-1-induced production of endothelin-1 in an in vitro model of the human blood???brain barrier

2002 • 53 citations

•NO and Oxyradical Metabolism in New Cell Lines of Rat Brain Capillary Endothelial Cells Forming the Blood–Brain Barrier

2001 • 52 citations

Signalling pathways regulating the tight junction permeability in the blood-brain barrier.

2003 • 52 citations

Interleukin-1 Modulates Protein Tyrosine Phosphatase Activity and Permeability of Brain Endothelial Cells

1997 • 51 citations

Alterations in transendothelial electrical resistance by vasoactive agonists and cyclic AMP in a blood-brain barrier model system.

1998 • 51 citations

Changes in brain microvessel endothelial cell monolayer permeability induced by adrenergic drugs

1994 • 50 citations

Differential Opening of the Brain Endothelial Following Neutralization of the Endothelial Luminal Anionic Charge In Vitro

1987 • 50 citations

Tumor Necrosis Factor‐α Increases Lactoferrin Transcytosis Through the Blood‐Brain Barrier

1999 • 48 citations

Effect of MK-801 and U83836E on a porcine brain capillary endothelial cell barrier during hypoxia

1995 • 47 citations

In vitro models to predict blood-brain barrier permeability

1997 • 46 citations

High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).

1999 • 44 citations

Use of a three-dimensional in vitro model of the rat blood–brain barrier to assay nucleoside efflux from brain

2003 • 43 citations

Permeability of neutral vs. anionic dextrans in cultured brain microvascular endothelium

1990 • 43 citations

N , N -diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine increases the permeability of primary mouse cerebral endothelial cell monolayers

2003 • 42 citations

Lessons from CADASIL

2002 • 42 citations

Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cell monolayers: the early effects of cyclic adenosine 3',5'‐monophosphate

1995 • 41 citations

Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers

1997 • 41 citations

Effect of tumor necrosis factor-alpha on the permeability of bovine brain microvessel endothelial cell monolayers

1997 • 41 citations

Endothelial Cells from Human Fetal Brain Microvessels May Be Cholinoceptive, but Do Not Synthesize Acetylcholine

1991 • 40 citations

Angiotensin Peptide Regulation of Bovine Brain Microvessel Endothelial Cell Monolayer Permeability

1991 • 40 citations

Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cells.

1989 • 39 citations

Isolation and primary culture of rat cerebral microvascular endothelial cells for studying drug transport in vitro

1996 • 39 citations

Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells

2003 • 38 citations

Effects of barbiturates on hypoxic cultures of brain derived microvascular endothelial cells

1996 • 37 citations

Nitric Oxide-Induced Blood–Brain Barrier Dysfunction Is Not Mediated by Inhibition of Mitochondrial Respiratory Chain Activity and/or Energy Depletion

1997 • 37 citations

Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood–brain barrier model system

1998 • 36 citations

Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers.

1999 • 35 citations

The blood-brain barrier : biology and research protocols

2003 • 34 citations

Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood–brain barrier

2001 • 34 citations

Oxygen Tension Regulates the Maturation of the Blood–Brain Barrier

2002 • 33 citations

Cultured Vascular Endothelial Cells of the Brain.

1996 • 31 citations

Functional role of adenosine receptor subtypes in the regulation of blood–brain barrier permeability: possible implications for the design of synthetic adenosine derivatives

2003 • 31 citations

In Vitro Effects of Fentanyl, Methohexital, and Thiopental on Brain Endothelial Permeability

1995 • 31 citations

In vitro reconstituted blood-brain barrier

1992 • 31 citations

Brain and Retinal Vascular Endothelial Cells with Extended Life Span Established by Ectopic Expression of Telomerase

2003 • 30 citations

Discussion

1999 • 30 citations

Transendothelial permeability of chlorpyrifos in RBE4 monolayers is modulated by astrocyte-conditioned medium

2001 • 30 citations

Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.

1997 • 29 citations

Schistosoma mansoniActivates Host Microvascular Endothelial Cells To Acquire an Anti-Inflammatory Phenotype

1999 • 29 citations

Evaluation of an in vitro coculture model for the blood-brain barrier: Comparison of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources

1999 • 29 citations

FAULTY INDUCTION OF BLOOD‐BRAIN BARRIER FUNCTIONS BY ASTROCYTES ISOLATED FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

1997 • 28 citations

Involvement of glial cells in cyclosporine-increased permeability of brain endothelial cells.

2000 • 28 citations

Monoacylation of ribonuclease A enables its transport across an in vitro model of the blood–brain barrier

1998 • 28 citations

Transport of Cationized Anti‐Tetanus Fab'2 Fragments Across an In Vitro Blood‐Brain Barrier Model: Involvement of the Transcytosis Pathway

1999 • 27 citations

Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model.

1998 • 25 citations

Histamine induces a selective albumin permeation through the blood-brain barrierin vitro

1995 • 24 citations

Relationship between in vitro transendothelial permeability and in vivo single-pass brain extraction.

1994 • 23 citations

Cerebromicrovascular endothelial permeability

1987 • 23 citations

No evidence for the involvement of the multidrug resistance-associated protein and/or the monocarboxylic acid transporter in the intestinal transport of fluvastatin in rats

2000 • 17 citations

Receptor‐Mediated Transcytosis of Cyclophilin B Through the Blood—Brain Barrier

1999 • 17 citations

Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells

1997 • 17 citations

Arachidonic acid and cerebromicrovascular endothelial permeability.

1990 • 15 citations

Barbiturates decrease the expression of vascular endothelial growth factor in hypoxic cultures of porcine brain derived microvascular endothelial cells

1998 • 15 citations

Effects of energy deprivation induced by fluorocitrate in immortalised rat brain microvessel endothelial cells

1996 • 14 citations

Acute energy deprivation syndromes: investigation of m-dinitrobenzene and alpha-chlorohydrin toxicity on immortalized rat brain microvessel endothelial cells.

1997 • 11 citations

Butyric acid mediated induction of enhanced transendothelial resistance in an in vitro model blood–brain barrier system

1999 • 10 citations

Blood-brain barrier permeability and stress; a study excitotoxic stress and vasogenic edema

1996 • 3 citations

Deleted Work

1955 • 0 citations