The blood-brain barrier in vitro: The second decade

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

A cell culture model of the blood-brain barrier.

1991 • 753 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

The isolation and characterization of acetylcholine-containing particles from brain

1959 • 570 citations

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

1987 • 523 citations

γ-Glutamyl Transpeptidase in Isolated Brain Endothelial Cells: Induction by Glial Cells in Vitro

1980 • 404 citations

Human Blood—Brain Barrier Insulin Receptor

1985 • 386 citations

Blood-brain barrier transcytosis of insulin in developing rabbits

1987 • 348 citations

Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease

1989 • 319 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Physiology and pharmacology of adenosine derivatives

1984 • 311 citations

Peptide Drug Delivery to the Brain

1992 • 309 citations

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide

1992 • 302 citations

Regulation of epithelial tight junction permeability by cyclic AMP

1981 • 296 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages.

1991 • 280 citations

Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells

1992 • 280 citations

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1989 • 251 citations

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

1992 • 250 citations

Molecular Anatomy of the Blood-Brain Barrier as Defined by Immunocytochemistry

1991 • 240 citations

Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

1993 • 223 citations

Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein.

1989 • 211 citations

In vivo relationship of tumor necrosis factor-α to blood-brain barrier damage in patients with active multiple sclerosis

1992 • 207 citations

Physiology and Pharmacology of the Blood-Brain Barrier

1992 • 199 citations

Blood-brain barrier protein recognized by monoclonal antibody.

1987 • 181 citations

Diminished Glucose Transport in Alzheimer's Disease: Dynamic PET Studies

1991 • 181 citations

A procedure for the isolation of capillaries from rat brain.

1973 • 180 citations

Differentiation-dependent expression of proteins in brain endothelium during development of the blood-brain barrier

1986 • 178 citations

Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal

1989 • 173 citations

ON THE ISOLATION OF NERVE ENDINGS AND SYNAPTIC VESICLES

1961 • 168 citations

Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2

1989 • 167 citations

Das Sauerstoff-Bedürfniss des Organismus

2013 • 164 citations

Brain induces the expression of an early cell surface marker for blood-brain barrier-specific endothelium.

1986 • 162 citations

The inducible blood-brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein.

1990 • 161 citations

The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain

1985 • 158 citations

Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55

1992 • 156 citations

Pathophysiology of the blood-brain barrier

1990 • 153 citations

Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

1989 • 153 citations

Studies on a Capillary-Rich Fraction Isolated from Brain: Histaminic Components and Characterization of the Histamine Receptors Linked to Adenylate Cyclase

1980 • 152 citations

Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells

1990 • 149 citations

Specialized Properties and Solute Transport in Brain Capillaries

1986 • 144 citations

The Cerebral Microvessels in Culture, an Update

1992 • 144 citations

The glucose transporter of the human brain and blood‐brain barrier

1988 • 144 citations

Cerebral microvessel endothelium is producing endothelin

1990 • 143 citations

Connexin43 in MDCK cells: regulation by a tumor-promoting phorbol ester and Ca2+.

1992 • 141 citations

A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels

1989 • 140 citations

Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro.

1990 • 140 citations

Histaminergic axons in the neostriatum and cerebral cortex of the rat: a correlated light and electron microscopic immunocytochemical study using histidine decar☐ylase as a marker

1986 • 137 citations

Recent Progress in the Study and Therapy of Brain Edema

1984 • 137 citations

Low‐Density Lipoprotein Receptor on Endothelium of Brain Capillaries

1989 • 136 citations

Neurothelin: an inducible cell surface glycoprotein of blood-brain barrier-specific endothelial cells and distinct neurons.

1990 • 126 citations

Rapid Sequestration and Degradation of Somatostatin Analogues by Isolated Brain Microvessels

1985 • 123 citations

Adhesion of lymphocytes to cerebral microvascular cells: effects of interferon-gamma, tumour necrosis factor and interleukin-1.

1988 • 119 citations

The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier

1990 • 114 citations

Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

1986 • 110 citations

A new aspect of the protective functions of the blood-brain barrier: Activities of four drug-metabolizing enzymes in isolated rat brain microvessels

1988 • 109 citations

Histochemical and ultrastructural characteristics of rat brain perivascular mast cells stimulated with compound 48/80 and carbachol

1990 • 108 citations

Enkephalin and Blood-Brain Barrier: Studies of Binding and Degradation in Isolated Brain Micro vessels*

1981 • 106 citations

Generation of superoxide anion by brain endothelial cell xanthine oxidase

1991 • 100 citations

Characterization of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium in vitro

1992 • 100 citations

Blood-Brain Glucose Transfer In Diabetes Mellitus: Decreased Number of Glucose Transporters at Blood-Brain Barrier

1986 • 97 citations

The blood-brain barrier regulates the expression of a macrophage sialic acid-binding receptor on microglia

1992 • 93 citations

Blood–Brain Barrier Pericytes Are the Main Source of γ‐Glutamyltranspeptidase Activity in Brain Capillaries

1992 • 92 citations

Correction of cell–cell communication defect by introduction of a protein kinase into mutant cells

1983 • 92 citations

Effect of N6O2-dibutyryl cyclic 3′,5′-adenosine monophosphate on the pinocytosis of brain capillaries of mice

1972 • 91 citations

Brain microvessels are innervated by locus ceruleus noradrenergic neurons

1989 • 91 citations

Capillary NMDA receptors regulate blood-brain barrier function and breakdown

1992 • 88 citations

Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayers

1990 • 87 citations

Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease

1992 • 87 citations

Cell-free fusion of endocytic vesicles is regulated by phosphorylation.

1992 • 87 citations

Absorptive-mediated endocytosis of a dynorphin-like analgesic peptide, E-2078 into the blood-brain barrier.

1989 • 86 citations

Endothelins activate Na+/H+ exchange in brain capillary endothelial cells via a high affinity endothelin-3 receptor that is not coupled to phospholipase C.

1991 • 86 citations

Blood-brain barrier breakdown by cold injury. Polyamine signals mediate acute stimulation of endocytosis, vesicular transport, and microvillus formation in rat cerebral capillaries.

1986 • 85 citations

Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein

1991 • 85 citations

Stretch‐activated non‐selective cation channels in the antiluminal membrane of porcine cerebral capillaries.

1992 • 84 citations

Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein

1989 • 83 citations

Major localization of aminopeptidase M in rat brain microvessels

1987 • 83 citations

Effects of Vasoactive Intestinal Polypeptide, Monoamines, Prostaglandins, and 2‐Chloroadenosine on Adenylate Cyclase in Rat Cerebral Microvessels

1983 • 83 citations

Recycling kinetics and transcytosis of transferrin in primary cultures of bovine brain microvessel endothelial cells

1991 • 82 citations

Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5′-untranslated region

1990 • 82 citations

Immunocytochemical expression of the endothelial barrier antigen (EBA) during brain angiogenesis

1992 • 81 citations

Pharmacology of cerebral ischemia

1992 • 78 citations

Adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine, and other agonists.

1979 • 78 citations

Neuronal and endothelial sites of acetylcholine synthesis and release associated with microvessels in rat cerebral cortex: ultrastructural and neurochemical studies

1988 • 77 citations

Pericytes of the brain microvasculature express γ‐glutamyl transpeptidase

1991 • 76 citations

Ultrastructural localization of lectin receptors on the luminal and abluminal aspects of brain micro-blood vessels.

1986 • 76 citations

Glucose transport is reduced in the blood-brain barrier of aged rats

1991 • 75 citations

Blood-brain barrier transport of choline is reduced in the aged rat

1988 • 75 citations

Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers

1990 • 73 citations

Absence of N-Methyl-D-Aspartate Receptors on Ovine Cerebral Microvessels

1988 • 72 citations

Distribution of the Glucose Transporter in the Mammalian Brain

1986 • 69 citations

Angiotensin II, vasopressin and GTP[γ-S] inhibit inward-rectifying K+ channels in porcine cerebral capillary endothelial cells

1991 • 69 citations

Adrenergic receptors of cerebral microvessels

1980 • 68 citations

Modulation of endothelial cell expression of intercellular adhesion molecule 1 by protein kinase c activation

1989 • 67 citations

Receptor-mediated changes in intracellular [Ca2+] in cultured rat brain capillary endothelial cells

1991 • 67 citations

Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood-brain barrier

1987 • 66 citations

A calcium and ATP sensitive nonselective cation channel in the antiluminal membrane of rat cerebral capillary endothelial cells

1992 • 65 citations

Secretion of Immunoreactive endothelin-1 by capillary and microvascular endothelium of human brain

1992 • 65 citations

Alterations of the Eicosanoid Synthetic Capacity of Rat Brain Microvessels Following Ischemia: Relevance to Ischemic Brain Edema

1985 • 64 citations

The tight-junction-specific protein ZO-l is a component of the human and rat blood-brain barriers

1991 • 63 citations

On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver.

1988 • 63 citations

Amyloid Angiopathy of Alzheimer's Disease: Amino Acid Composition and Partial Sequence of a 4,200‐Dalton Peptide Isolated from Cortical Microvessels

1987 • 63 citations

A One‐Step Procedure for Isolation of Poly(A)⁺ mRNA from Isolated Brain Capillaries and Endothelial Cells in Culture

1991 • 63 citations

Blood–Brain Barrier Protein and Phosphorylation and Dephosphorylation

1985 • 62 citations

Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity

1989 • 61 citations

Regulation of the macromolecular transport in the brain microvessels: The role of cyclic GMP

1983 • 60 citations

Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II: Alteration of the eicosanoid synthesis profile of brain microvessels.

1985 • 60 citations

Regulation of Brain Water and Electrolyte Contents: The Possible Involvement of Central Atrial Natriuretic Factor

1987 • 59 citations

Transport of ions across the blood-brain barrier.

1986 • 59 citations

Functional identification of adenylate cyclase-coupled adenosine receptors in rat brain microvessels

1982 • 57 citations

γ-Glutamyltranspeptidase induction mediated by glial foot process-to endothelium contact in co-culture

1981 • 57 citations

Cerebral endothelial cell culture I. The presence of β2 and α2-adrenergic receptors linked to adenylate cyclase activity

1982 • 57 citations

Phenylalanine Transport at the Human Blood-Brain Barrier

1988 • 55 citations

Synthesis of Apolipoprotein A‐1 in Pig Brain Microvascular Endothelial Cells

1990 • 55 citations

Correlation of blood-brain barrier function and HT7 protein distribution in chick brain circumventricular organs

1990 • 54 citations

Gamma-glutanyl-transpeptidase (GGTP) and NA+K+-ATPase activities in different subpopulations of cloned cerebral endothelial cells: Reponses to glial stimulation

1990 • 54 citations

Protein phosphorylation in cultured endothelial cells

1986 • 54 citations

Role of cerebral endothelium in brain oedema

1989 • 53 citations

Evidence for an Alanine, Serine, and Cysteine System of Transport in Isolated Brain Capillaries

1987 • 53 citations

Blood-brain barrier glucose transporter mRNA is increased in experimental diabetes mellitus

1989 • 53 citations

Protective effect of antihistamines on cerebral oedema induced by experimental pneumothorax in newborn piglets

1987 • 52 citations

Antibodies to Blood—Brain Barrier Bind Selectively to Brain Capillary Endothelial Lateral Membranes and to a 46K Protein

1986 • 52 citations

Identification and characterization of the glucose-transport protein of the bovine blood/brain barrier

1987 • 52 citations

High-affinity transport of glutamate in rat brain microvessels

1985 • 52 citations

cDNA Cloning and Sequence Analysis of the Glucose Transporter from Porcine Blood-Brain Barrier

1989 • 51 citations

Neuronal versus endothelial origin of vasoactive acetylcholine in pial vessels

1987 • 51 citations

Characterization of the blood-brain barrier: glycoconjugate receptors of 14 lectins in canine brain, cultured endothelial cells, and blotted membrane proteins

1987 • 51 citations

The blood-brain barrier: New aspects to the function of the cerebral endothelium

1986 • 50 citations

Effects of atrial natriuretic peptide on ischemic brain edema in rats evaluated by proton magnetic resonance method.

1991 • 48 citations

Specific binding of atrial natriuretic factor in brain microvessels.

1987 • 48 citations

Enhancement of ATPase Activity by a Lipid Peroxide of Arachidonic Acid in Rat Brain Microvessels

1986 • 47 citations

Antigen presentation in brain: brain endothelial cells are poor stimulators of T-cell proliferation.

1989 • 46 citations

Activation by Nitric Oxide of Guanylate Cyclase in Endothelial Cells from Brain Capillaries

1992 • 46 citations

Potassium activation of the Na,K-pump in isolated brain microvessels and synaptosomes

1990 • 45 citations

The blood-brain barrier in hypoxia: Ultrastructural aspects and adenylate cyclase activity of brain capillaries

1984 • 45 citations

Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier

1992 • 45 citations

Increased α2- and β2-adrenergic receptors in cerebral microvessels in Alzheimer disease

1989 • 44 citations

Synthesis of acetylcholine by endothelial cells isolated from rat brain cortex capillaries

1987 • 44 citations

Ultrastructural localization of lectin receptors on cerebral endothelium

1985 • 44 citations

Factors controlling the in Vitro growth pattern of human microvascular endothelial cells

1983 • 44 citations

Ischemia/reperfusion-induced changes in membrane fluidity characteristics of brain capillary endothelial cells and its prevention by liposomal-incorporated superoxide dismutase

1991 • 44 citations

Insulin Binding to the Blood‐Brain Barrier in the Streptozotocin Diabetic Rat

1986 • 43 citations

Adenosine Receptors of Cerebral Microvessels and Choroid Plexus

1986 • 43 citations

Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain

1988 • 43 citations

Isolated Brain Microvessels as In Vitro Equivalents of the Blood‐Brain Barrier: Selective Removal by Collagenase of the A‐System of Neutral Amino Acid Transport

1987 • 43 citations

Atrial Natriuretic Peptide Modulates Amiloride‐Sensitive Na⁺ Transport Across the Blood‐Brain Barrier

1989 • 43 citations

Endothelins inhibit adenylate cyclase in brain capillary endothelial cells

1991 • 42 citations

Glucose Transporter of the Blood‐Brain Barrier and Brain in Chronic Hyperglycemia

1988 • 42 citations

NBQX, an AMPA antagonist, reduces glutamate-mediated brain edema

1992 • 42 citations

Substance P stimulates translocation of protein kinase C in brain microvessels

1989 • 42 citations

Endothelial Cells from Human Fetal Brain Microvessels May Be Cholinoceptive, but Do Not Synthesize Acetylcholine

1991 • 40 citations

Cerebral vascular endothelial cells are effective targets for in vitro lysis by encephalitogenic T lymphocytes.

1991 • 40 citations

Effects of forskolin on growth and morphology of cultured glial and cerebrovascular endothelial and smooth muscle cells

1987 • 40 citations

Neurothelin: molecular characteristics and developmental regulation in the chick CNS

1991 • 39 citations

γ‐Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity

1992 • 38 citations

Characteristics of Aminopeptidase Activity from Bovine Brain Microvessel Endothelium

1987 • 38 citations

Characterization of microvascular cell cultures from normotensive and hypertensive rat brains: Pericyte—endothelial cell interactions in vitro

1987 • 38 citations

Diacylglycerol lipase and kinase activities in rat brain microvessels

1985 • 38 citations

Oxygen Free‐Radical Reduction of Brain Capillary Rubidium Uptake

1986 • 36 citations

Receptor‐Linked Hydrolysis of Phosphoinositides and Production of Prostacyclin in Cerebral Endothelial Cells

1992 • 36 citations

Kinetics of Choline Uptake into Isolated Rat Forebrain Microvessels: Evidence of Endocrine Modulation

1988 • 36 citations

Isolated rat brain capillarie spossess intact, structurally complex, interendothelial tight junctions; freeze-fracture verification of tight junction integrity

1984 • 36 citations

Regulation of ion permeability in frog brain venules. Significance of calcium, cyclic nucleotides and protein kinase C.

1987 • 36 citations

Calcium/Calmodulin‐Stimulated Protein Kinase II Is Present in Primary Cultures of Cerebral Endothelial Cells

1993 • 35 citations

Polyamines and Ca²⁺ Mediate Hyperosmolal Opening of the Blood‐Brain Barrier: In Vitro Studies in Isolated Rat Cerebral Capillaries

1989 • 35 citations

Lymphocyte migration into the CNS modelled in vitro

1992 • 35 citations

Brain Capillary 46,000 Dalton Protein is Cytoplasmic Actin and is Localized to Endothelial Plasma Membrane

1989 • 34 citations

Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: effects of unilateral locus ceruleus lesion

1987 • 34 citations

A new model for multiple sclerosis: Chronic experimental allergic encephalomyelitis induced by immunization with cerebral endothelial cell membrane

1987 • 34 citations

Saturable Retention of Vasopressin by Hippocampus Vessels In Vivo, Associated with Inhibition of Blood‐Brain Transfer of Large Neutral Amino Acids

1987 • 34 citations

Energy state of bovine cerebral microvessels: Comparison of isolation methods

1988 • 34 citations

Characterization of Neuronal and Endothelial Forms of Angiotensin Converting Enzyme in Pig Brain

1991 • 33 citations

Peptide Drug Delivery to the Brain

1992 • 32 citations

Arginine vasopressin receptors in pig cerebral microvessels, cerebral cortex and hippocampus

1988 • 32 citations

Pharmacological properties of voltage-dependent calcium channels in functional microvessels isolated from rat brain

1989 • 32 citations

C-type natriuretic peptide is a potent activator of guanylate cyclase in endothelial cells from brain microvessels

1992 • 32 citations

Characterization of specific receptors for atrial natriuretic factor on cultured bovine brain capillary endothelial cells

1988 • 32 citations

On the blood-brain barrier to peptides: specific binding of atrial natriuretic peptide in vivo and in vitro

1991 • 31 citations

Insulin action on brain microvessels; Effect on alkaline phosphatase

1988 • 31 citations

Distribution of guanylate cyclase in rat cerebral cortex: Neuronal, glial, capillary, pia-arachnoid and synaptosomal fractions plus choroid plexus

1981 • 31 citations

Immunocytochemical localization of the glucose-transport protein in mammalian brain capillaries

1989 • 31 citations

Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats

1989 • 31 citations

Immumochemical and immunocytochemial characterization of a novel monoclonal antibody recognizing a 140 kDa protein in cerebral pericytes of the rat

1988 • 30 citations

Choline Acetyltransferase Activity Associated with Cerebral Cortical Microvessels Does Not Originate in Basal Forebrain Neurons

1991 • 30 citations

Membrane-bound lipoxygenase of rat cerebral microvessels

1985 • 29 citations

Kinetics of Protein Phosphorylation in Microvessels Isolated from Rat Brain: Modulation by Second Messengers

1988 • 29 citations

Immunocytochemically stained vasopressin binding sites on blood vessels in the rat brain

1988 • 29 citations

Effect of several vasoactive agents on guanylate cyclase activity in isolated rat brain microvessels

1989 • 29 citations

Adrenergic receptors on cerebral microvessels: pericyte contribution

1989 • 28 citations

β-adrenergic receptors in brain microvessels of diabetic rats

1984 • 28 citations

Coexpression of ß₁‐ and ß₂‐Adrenergic Receptors on Bovine Brain Capillary Endothelial Cells in Culture

1991 • 27 citations

Changes in the activity of γ-glutamyl transpeptidase in brain microvessels, astroglial cells and synaptosomes derived from rats with hepatic encephalopathy

1988 • 27 citations

Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains

1991 • 26 citations

Catecholamines stimulate the IFN-gamma-induced class II MHC expression on bovine brain capillary endothelial cells.

1991 • 26 citations

Sulfated Glucuronyl Paragloboside in Rat Brain Microvessels

1990 • 26 citations

A monoclonal antibody to the endothelium of rat brain microvessels

1986 • 26 citations

Class II MHC antigen expression by cultured human cerebral vascular endothelial cells

1991 • 25 citations

Presentation of myelin basic protein by normal guinea-pig brain endothelial cells and its relevance to experimental allergic encephalomyelitis.

1989 • 25 citations

Ca2+ depletion-induced disconnection of tight junctions in isolated rat brain microvessels

1985 • 23 citations

The vasopressin receptor of the blood-brain barrier in the rat hippocampus is linked to calcium signalling

1991 • 22 citations

Bradykinin Receptors of Cerebral Microvessels Stimulate Phosphoinositide Turnover

1991 • 22 citations

Butyrylcholinesterase in pericytes associated with canine brain capillaries

1987 • 21 citations

Tumor-promoting phorbol esters stimulate bovine cerebral cortex capillary endothelial cell growth in vitro

1989 • 21 citations

Phorbol ester stimulates hexose uptake by brain microvessel endothelial cells

1988 • 21 citations

Specific atrial natriuretic peptide binding sites in rat cerebral capillaries

1988 • 21 citations

Cyclic 3?,5?-adenosine monophosphate phosphodiesterase (cAMP PDE) and cyclic 3?,5?-guanosine monophosphate phosphodiesterase (cGMP PDE) in microvessels isolated from bovine cortex

1979 • 20 citations

Glial cells in coculture can increase the acetylcholinesterase activity in human brain endothelial cells

1992 • 20 citations

Periendothelial Acetylcholine Synthesis and Release in Bovine Cerebral Cortex Capillaries

1991 • 20 citations

Demonstration of Acid Hydrolase Activity in Primary Cultures of Bovine Brain Microvessel Endothelium

1989 • 20 citations

The effect of age on protein composition of rat cerebral microvessels

1992 • 20 citations

Adenosine receptors in capillaries and pia-arachnoid of rat cerebral cortex

1982 • 20 citations

Stimulation of tryptophan uptake into brain microvessels byd-glutamine

1986 • 20 citations

Choline Transport and Metabolism in Soman‐or Sarin‐Intoxicated Brain

1988 • 20 citations

Lectin histochemistry of cerebral microvessels in ageing, Alzheimer's disease and Down's syndrome

1992 • 19 citations

Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations

1988 • 19 citations

Differential Postnatal Development of Monoamine Oxidases A and B in the Blood‐Brain Barrier of the Rat

1987 • 19 citations

Biochemical characterization and subcellular distribution of the glucose transporter from rat brain microvessels

1987 • 19 citations

Characterization of atrial natriuretic peptide receptors in brain microvessel endothelial cells

1991 • 19 citations

Choline Acetyltransferase Activity in the Rat Brain Cortex Homogenate, Synaptosomes, and Capillaries After Lesioning the Nucleus Basalis Magnocellularis

1988 • 19 citations

Developmental changes in enzymatic systems involved in protection against peroxidation in isolated rat brain microvessels

1992 • 19 citations

Purified Rat Brain Microvessels Exhibit Both Acid and Neutral Sphingomyelinase Activities

1989 • 19 citations

The effect of heat shock on primary cultures of brain capillary endothelium: inhibition of assembly of zonulae occludentes and the synthesis of heat-shock proteins.

1988 • 18 citations

Isolation of intact capillaries and capillary plasma membranes from frozen human brain

1987 • 18 citations

Angiotensin‐Converting Enzyme Activity Is Reduced in Brain Microvessels of Spontaneously Hypertensive Rats

1984 • 17 citations

Adrenergic, serotoninergic, histaminergic, and imipramine binding sites in post-mortal human cerebral microvessel preparations

1988 • 17 citations

Characterization of Neuronal and Glial Fractions Separated in Sucrose and Ficoll Media

1971 • 17 citations

Adhesion of splenocytes to brain microvascular endothelium in the BALB/c and SJL/j mouse systems

1991 • 17 citations

Control of [3H]ouabain binding to cerebromicrovascular (Na+ + K+)-ATPase by metal ions and proteins

1990 • 17 citations

Uptake of Amino Acids by Brain Micro vessels Isolated from Rats with Experimental Chronic Renal Failure

1988 • 16 citations

Isolation and Partial Characterization of a 56,000‐Dalton Phosphoprotein Phosphatase from the Blood‐Brain Barrier

1987 • 16 citations

Effects of selected vasoactive substances on adenylate cyclase activity in brain, isolated brain microvessels, and primary cultures of brain microvessel endothelial cells

1992 • 16 citations

Stimulation of cyclic adenosine monophosphate accumulation causes breakdown of the blood-retinal barrier.

1991 • 16 citations

Fatty acid oxidation of rat brain microvessels in hypertension, aging and experimental diabetes

1982 • 16 citations

Modulation of adhesion of lymphocytes to murine brain endothelial cells in vitro: relation to class II major histocompatibility complex expression

1992 • 15 citations

Effects of acute hypoxia on the adenylate cyclase and evans blue transport of brain microvessels

1987 • 15 citations

Developmental changes in brain and serum binding of testosterone and in brain capillary uptake of testosterone-binding serum proteins in the rabbit

1988 • 15 citations

Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose

1991 • 14 citations

Age-dependent alteration in regional cerebrovascular permeability during drug-induced epilepsy

1992 • 14 citations

Adrenergic receptors on cerebral microvessels in control and Parkinsonian subjects

1985 • 14 citations

Angiotensin II and atrial natriuretic factor receptor interactions at the blood-brain barrier

1991 • 14 citations

Adenylate cyclase sensitivity to catecholamines and forskolin in rat pia-arachnoid and cerebral microvessels

1983 • 14 citations

Dietary manipulation with high marine fish oil intake of fatty acid composition and arachidonic acid metabolism in rat cerebral microvessels

1992 • 14 citations

The synthesis of lipids from [1-14C]acetate by isolated rat brain capillaries

1985 • 14 citations

Regulation of amino acid uptake into cerebral microvessels

1992 • 13 citations

Subtypes of adrenergic and dopaminergic receptors in bovine cerebral blood vessels

1988 • 13 citations

The Effect of Bradykinin and its Fragments on the Arachidonate Cascade of Brain Microvessels

1989 • 13 citations

Isolation and Partial Characterization of an 80,000‐Dalton Protein Kinase from the Micro vessels of the Porcine Brain

1989 • 13 citations

Immunology of Brain Endothelium and the Blood-Brain Barrier

1992 • 12 citations

Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels

1988 • 12 citations

The effect of aluminum on muscarinic receptors in isolated cerebral microvessels.

1991 • 11 citations

Vascular Cholinesterases and Choline Uptake in Isolated Rat Forebrain Microvessels: A Possible Link

1989 • 11 citations

A Micromethod for the Isolation of Large and Small Microvessels from Frozen Autopsied Human Brain

1987 • 10 citations

Effect of osmolarity on potassium transport in isolated cerebral microvessels

1988 • 9 citations

Molecular forms of butyrylcholinesterase in rat brain microvessels

1990 • 9 citations

Histamine augments interleukin-2 production and the activation of cytotoxic T lymphocytes

1986 • 9 citations

Corticosteroid receptors in cells derived from rat brain microvessels: mRNA identification and aldosterone binding

1992 • 9 citations

Autoimmune encephalomyelitis in rhesus monkeys induced by immunization with cerebral endothelial cell membrane

1988 • 9 citations

Basic Molecular Events Underlying Transendothelial Transport in Brain Capillaries

1984 • 8 citations

Arachidonoyl‐Coenzyme A Synthetase and Nonspecific AcylCoenzyme A Synthetase Activities in Purified Rat Brain Microvessels

1987 • 8 citations

Evidence for a regulatory action of vanadate on protein phosphorylation in brain microvessels

1989 • 8 citations

Vascular monoamine oxidase activity in the rat brain: Variation with the substrate and the vascular segment

1985 • 8 citations

Durable inhibition of rat cerebral capillary Na+/K+-ATPase after in vivo administration of mercuric chloride

1991 • 7 citations

Calcium-imaging with Fura-2 in isolated cerebral microvessels

1989 • 7 citations

Ethanol Administration in the Rat Decreases Prostacyclin Production by Isolated Brain Microvessels

1986 • 7 citations

Glial Brain Tumors Lack Microvascular Adrenergic Receptors

1988 • 6 citations

Microvessels from the Spinal Cord: Isolation Procedure and Characterization of the Fraction

1982 • 6 citations

Monoamine oxidase in young and adult rat brain capillaries

1984 • 6 citations

Isolation and Transport Properties of Brain Microvessels

1990 • 5 citations

Brain endothelial cells infected by AIDS virus

1986 • 4 citations

Neuropeptide degradation by large vessel and microvessel-derived endothelial cells in vitro: cell surface catabolism of thyrotropin releasing hormone (TRH)

1989 • 4 citations

Comparison of stimulated tissue factor expression by brain microvascular endothelial cells from normotensive (WKY) and hypertensive (SHR) rats

1992 • 4 citations

Monoamine oxidase activity in chick cerebral microvessels

1986 • 3 citations

Deleted Work

1955 • 0 citations