Rat Brain Endothelial Cell Lines for the Study of Blood–Brain Barrier Permeability and Transport Functions

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Selective expression of the large neutral amino acid transporter at the blood–brain barrier

1999 • 457 citations

In vitro model for evaluating drug transport across the blood–brain barrier

1999 • 349 citations

Establishment and functional characterization of an in vitro model of the blood–brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes

2001 • 323 citations

Regulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

1994 • 313 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

2000 • 296 citations

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

2001 • 274 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

1994 • 241 citations

Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

2002 • 207 citations

Functional expression and localization of P‐glycoprotein at the blood brain barrier

2002 • 178 citations

Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.

1995 • 178 citations

Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells

2003 • 176 citations

Interaction of Poly(butylcyanoacrylate) Nanoparticles with the Blood-Brain Barrierin vivoandin vitro

2001 • 167 citations

Functional relevance of carnitine transporter OCTN2 to brain distribution of<scp>l</scp>‐carnitine and acetyl‐<scp>l</scp>‐carnitine across the blood–brain barrier

2001 • 155 citations

SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics

1996 • 155 citations

Nitric oxide and endothelin secretion by brain microvessel endothelial cells: Regulation by cyclic nucleotides

1993 • 123 citations

By-passing of P-glycoprotein Using Immunoliposomes

2002 • 123 citations

Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies.

2000 • 120 citations

Regulation of taurine transport at the blood–brain barrier by tumor necrosis factor‐α, taurine and hypertonicity

2002 • 116 citations

A co-culture-based model of human blood–brain barrier: application to active transport of indinavir and in vivo–in vitro correlation

2002 • 115 citations

Endocytosis and Transcytosis of an Immunoliposome-Based Brain Drug Delivery System

2000 • 103 citations

F-Actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors

1997 • 103 citations

mRNA Expression and Transport Characterization of Conditionally Immortalized Rat Brain Capillary Endothelial Cell Lines; a Newin vitroBBB Model for Drug Targeting

2000 • 99 citations

Dexamethasone Regulation of P‐Glycoprotein Activity in an Immortalized Rat Brain Endothelial Cell Line, GPNT

1999 • 98 citations

Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier

1999 • 93 citations

Endocytosis and transcytosis

1990 • 93 citations

Nitric oxide protects blood‐brain barrier in vitro from hypoxia/reoxygenation‐mediated injury

1998 • 93 citations

The blood-brain barrier in vitro: The second decade

1993 • 92 citations

l-DOPA transport properties in an immortalised cell line of rat capillary cerebral endothelial cells, RBE 4

1999 • 87 citations

Conditionally Immortalized Cell Lines as a New In Vitro Model for the Study of Barrier Functions

2001 • 87 citations

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

2000 • 84 citations

Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier

2001 • 82 citations

Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT

2000 • 78 citations

Affinity for the P-Glycoprotein Efflux Pump at the Blood-Brain Barrier May Explain the Lack of CNS Side-Effects of Modern Antihistamines

2001 • 77 citations

ATA2 Is Predominantly Expressed as System A at the Blood-Brain Barrier and Acts as Brain-to-Blood Efflux Transport forl-Proline

2002 • 71 citations

Interactions between Brain Endothelial Cells and Human T-Cell Leukemia Virus Type 1-Infected Lymphocytes: Mechanisms of Viral Entry into the Central Nervous System

2000 • 70 citations

Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4)

2001 • 65 citations

Functional feature of a novel model of blood brain barrier: studies on permeation of test compounds

2001 • 64 citations

Synergistic stimulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities by retinoic acid and astroglial factors in immortalized rat brain microvessel endothelial cells

1996 • 62 citations

Down-regulation of blood-brain glucose transport in the hyperglycemic nonobese diabetic mouse

1995 • 59 citations

Functional Expression of the Serotonin Transporter in Immortalized Rat Brain Microvessel Endothelial Cells

2000 • 54 citations

Brain capillary endothelial cells in vitro lack surface IgG Fc receptors

1986 • 53 citations

•NO and Oxyradical Metabolism in New Cell Lines of Rat Brain Capillary Endothelial Cells Forming the Blood–Brain Barrier

2001 • 52 citations

Glucose transport in immortalized rat brain capillary endothelial cells in vitro: transport activity and GLUT1 expression

1997 • 52 citations

Factor(s) released by glucose-deprived astrocytes enhance glucose transporter expression and activity in rat brain endothelial cells

2001 • 50 citations

Vasoactive substances produced by cultured rat brain endothelial cells

1999 • 46 citations

Lack of Histamine Synthesis and Down-Regulation of H₁ and H₂ Receptor mRNA Levels by Dexamethasone in Cerebral Endothelial Cells

1999 • 44 citations

Recent advances in the brain-to-blood efflux transport across the blood–brain barrier

2002 • 43 citations

Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood–brain barrier

2003 • 41 citations

Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines

2003 • 33 citations

Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line

1997 • 33 citations

Carrier-Mediated Delivery of Metabotropic Glutamate Receptor Ligands to the Central Nervous System: Structural Tolerance and Potential of the <scp>l</scp>-system Amino Acid Transporter at the Blood-Brain Barrier

2000 • 31 citations

Transendothelial permeability of chlorpyrifos in RBE4 monolayers is modulated by astrocyte-conditioned medium

2001 • 30 citations

Lipid Synthesis by Rat Brain Microvessel Endothelial Cells in Tissue Culture

1989 • 27 citations

Blood–Brain Barrier Controls Carnitine Level in the Brain: A Study on a Model System with RBE4 Cells

2000 • 26 citations

Characterization of Transferrin Receptor in an Immortalized Cell Line of Rat Brain Endothelial Cells, RBE4

1999 • 23 citations

S-adenosylmethionine is substrate for carrier mediated transport at the blood–brain barrier in vitro

2002 • 23 citations

Regulation of [ 3 H]MPP + transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase

2002 • 21 citations

The blood–brain barrier. Biology and research protocols

2003 • 19 citations

Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells

1997 • 17 citations

Evaluation of the RBE4 Cell Line to Explore Carrier-mediated Drug Delivery to the CNS Via the L-system Amino Acid Transporter At the Blood-Brain Barrier

2002 • 17 citations

Tissue plasminogen activator inhibits P-glycoprotein activity in brain endothelial cells

2001 • 16 citations

Rapid Induction of Long-Lasting Drug Efflux Activity in Brain Vascular Endothelial Cells But Not Malignant Glioma Following Irradiation

2002 • 14 citations

Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein

2000 • 12 citations

Acute energy deprivation syndromes: investigation of m-dinitrobenzene and alpha-chlorohydrin toxicity on immortalized rat brain microvessel endothelial cells.

1997 • 11 citations

Mercury-stimulated histamine uptake and binding in cultured astroglial and cerebral endothelial cells.

1997 • 8 citations

Development and Characterization of Immortalized Cerebral Endothelial Cell Lines

2003 • 7 citations

Mercury-stimulated histamine uptake and binding in cultured astroglial and cerebral endothelial cells

1997 • 4 citations

INHIBITION OF CALCIUM‐INDEPENDENT LUMINAL UPTAKE OF L‐DOPA BY CALMODULIN ANTAGONISTS IN IMMORTALIZED RAT CAPILLARY CEREBRAL ENDOTHELIAL CELLS

2001 • 3 citations