Hypothermia abolishes hypoxia-induced hyperpermeability in brain microvessel endothelial cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein.

1984 • 1,249 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.

1994 • 433 citations

Therapeutic modulation of brain temperature: relevance to ischemic brain injury.

1992 • 429 citations

The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children

1991 • 362 citations

The Significance of Brain Temperature in Focal Cerebral Ischemia: Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat

1992 • 353 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

The Influence of Mild Body and Brain Hypothermia on Ischemic Brain Damage

1990 • 351 citations

Nitric oxide as a signal in blood vessels

1992 • 285 citations

The Relationship among Canine Brain Temperature, Metabolism, and Function during Hypothermia

1991 • 276 citations

Mild Hypothermia Prevents Ischemic Injury in Gerbil Hippocampus

1990 • 275 citations

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1989 • 251 citations

Mild Intraischemic Hypothermia Reduces Postischemic Hyperperfusion, Delayed Postischemic Hypoperfusion, Blood-Brain Barrier Disruption, Brain Edema, and Neuronal Damage Volume after Temporary Focal Cerebral Ischemia in Rats

1994 • 245 citations

The Metabolic Effects of Mild Hypothermia on Global Cerebral Ischemia and Recirculation in the Cat: Comparison to Normothermia and Hyperthermia

1989 • 240 citations

Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO

1999 • 239 citations

Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia

1994 • 220 citations

Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats.

1992 • 210 citations

Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels

1992 • 197 citations

Hypoxia regulatory elements of the human vascular endothelial growth factor gene.

1994 • 196 citations

Effect on Canine Brain and Whole-body Metabolism

1968 • 193 citations

Moderate Hypothermia Reduces Postischemic Edema Development and Leukotriene Production

1987 • 191 citations

The effect of profound hypothermia on preservation of cerebral ATP content during circulatory arrest

1968 • 183 citations

Mild hypothermic intervention after graded ischemic stress in rats.

1991 • 175 citations

The importance of brain temperature in cerebral injury.

1992 • 170 citations

Protection from cerebral ischemia by brain cooling without reduced lactate accumulation in dogs.

1989 • 145 citations

Endothelial Cell‐Astrocyte Interactions

1988 • 140 citations

Hypothermia and cardiac arrest in the treatment of giant aneurysms of the cerebral circulation and hemangioblastoma of the medulla

1981 • 139 citations

Mild Hypothermia: Therapeutic Window after Experimental Cerebral Ischemia

1996 • 131 citations

Permeability of human endothelial monolayers: effect of vasoactive agonists and cAMP

1989 • 128 citations

The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass

1992 • 124 citations

Characterization of ?-glutamyl transpeptidase activity of cultured endothelial cells from porcine brain capillaries

1989 • 122 citations

Effect of Mild Hypothermia on Cerebral Energy Metabolism During the Evolution of Hypoxic-Ischemic Brain Damage in the Immature Rat

1996 • 108 citations

Effects of Hypothermia or Anesthetics on Hippocampal Glutamate and Glycine Concentrations after Repeated Transient Global Cerebral Ischemia

1994 • 106 citations

Effects of Hypothermic Metabolic Suppression on Hippocampal Glutamate Concentrations After Transient Global Cerebral Ischemia

1994 • 102 citations

Hypothermic suppression of microglial activation in culture: inhibition of cell proliferation and production of nitric oxide and superoxide

1997 • 94 citations

Conditions for pharmacologic evaluation in the gerbil model of forebrain ischemia.

1989 • 87 citations

Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene

1997 • 84 citations

Modest Hypothermia Preserves Cerebral Energy Metabolism during Hypoxia-Ischemia and Correlates with Brain Damage: A 31P Nuclear Magnetic Resonance Study in Unanesthetized Neonatal Rats

1997 • 63 citations

Regulation of the macromolecular transport in the brain microvessels: The role of cyclic GMP

1983 • 60 citations

Neonatal Ischemic Neuroprotection by Modest Hypothermia Is Associated With Attenuated Brain Acidosis

1995 • 52 citations

Hypothermia-induced reduction in the permeation of radiolabelled tracer substances across the blood-brain barrier

1983 • 44 citations

Response of cerebral endothelial cells to hypoxia: modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists

1994 • 43 citations

Effects of barbiturates on hypoxic cultures of brain derived microvascular endothelial cells

1996 • 37 citations

Magnetic Resonance Imaging and ³¹P Magnetic Resonance Spectroscopy Study of the Effect of Temperature on Ischemic Brain Injury

1992 • 37 citations

Hypothermia suppresses nitric oxide elevation during reperfusion after focal cerebral ischemia in rats

1996 • 36 citations

Relationship between tissue respiration and total metabolic rate in hypo- and normothermic rats

1961 • 32 citations

Electrical resistance measurements on cerebral capillary endothelial cells — a new technique to study small surface areas

1995 • 30 citations

Role of Adenosine in the Hypoxic Induction of Vascular Endothelial Growth Factor in Porcine Brain Derived Microvascular Endothelial Cells

1997 • 25 citations

Neuronal damage, glial response and cerebral metabolism after hypothermic forebrain ischemia in the rat

1992 • 25 citations

Hypothermia-induced potentiation of histamine H2-receptor-mediated relaxation and cyclic AMP increase in the isolated mesenteric artery of the rabbit

1979 • 20 citations

The Influence of Fentanyl upon Cerebral High-energy Metabolites, Lactate, and Glucose during Severe Hypoxia in the Rat

1988 • 19 citations

Effect of High vs. Low Arterial Blood Oxygen Content on Cerebral: Energy Metabolite Levels during Hypoxia with: Normothermia and Hypothermia in the Rat

1980 • 15 citations

Barbiturates decrease the expression of vascular endothelial growth factor in hypoxic cultures of porcine brain derived microvascular endothelial cells

1998 • 15 citations

The role of cyclic AMP in temperature-dependent changes of contractile force and sensitivity to isoprenaline and papaverine in guinea-pig atria

1978 • 13 citations

Different effects of hypothermia on amino acid incorporation and on amino acid uptake in the brainin vivo

1992 • 9 citations

Cell adhesion-dependent regulation of cell growth during sea urchin development.

1996 • 9 citations

IN VITRO STUDIES OF THE BLOOD-BRAIN BARRIER.

1986 • 2 citations