Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells.

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

The influence of cytokines on the integrity of the blood-brain barrier in vitro

1996 • 641 citations

Bacterial Meningitis: Pathogenesis, Pathophysiology, and Progress

1992 • 488 citations

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1995 • 414 citations

Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.

1989 • 411 citations

Bovine Brain Microvessel Endothelial Cell Monolayers as a Model System for the Blood‐Brain Barriera

1987 • 177 citations

Elevated alpha–tumor necrosis factor levels in spinal fluid from HIV‐1–infected patients with central nervous system involvement

1991 • 170 citations

Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide

1998 • 168 citations

Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays

1997 • 167 citations

Blood-Brain Barrier Damage in Patients with Bacterial Meningitis: Association with Tumor Necrosis Factor- but not Interleukin-I

1992 • 157 citations

Exposure of tumor necrosis factor‐α to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin

1995 • 153 citations

Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat.

1992 • 151 citations

Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha.

1994 • 147 citations

Specific NF‐κB blockade selectively inhibits tumour necrosis factor‐α‐induced COX‐2 but not constitutive COX‐1 gene expression in HT‐29 cells

1998 • 139 citations

Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-α exposure

1999 • 136 citations

Elevated serum levels of tumor necrosis factor‐α in Guillain‐Barré syndrome

1993 • 117 citations

Tumor Necrosis Factor-α Inversely Regulates Prostaglandin D2 and Prostaglandin E2 Production in Murine Macrophages

1997 • 98 citations

Eicosanoid metabolism in cerebromicrovascular endothelium

1988 • 94 citations

Application of cultured endothelial cells of the brain microvasculature in the study of the blood-brain barrier

1992 • 81 citations

Intracarotid tumor necrosis factor-α administration increases the blood-brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis

1996 • 81 citations

Nitric oxide and prostaglandin E2 formation parallels blood–brain barrier disruption in an experimental rat model of bacterial meningitis

1998 • 76 citations

Tumor Necrosis factor- and Expression of the Multidrug Resistance-Associated Genes LRP and MRP

1997 • 66 citations

Identification and distribution of insulin receptors on cultured bovine brain microvessel endothelial cells: Possible function in insulin processing in the blood–brain barrier

1994 • 61 citations

The effect of nitric oxide on cytokine‐induced release of PGE₂ by human cultured astroglial cells

1998 • 59 citations

Stimulation of prostaglandin (PG) F2α and PGE2 release by tumour necrosis factor-α and interleukin-1α in cultured human luteal phase endometrial cells

1995 • 55 citations

Combinations of low concentrations of cytokines and acute agonists synergize in increasing the permeability of endothelial monolayers

1993 • 44 citations

Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative disease

1998 • 37 citations

Expression of cyclooxygenase-2 in rat vascular smooth muscle cells is unrelated to nuclear factor-κB activation

1999 • 33 citations

Prostaglandin E2-protein kinase a signaling and protein phosphatases-1 and -2A regulate human head and neck squamous cell carcinoma motility, adherence, and cytoskeletal organization

1996 • 23 citations

TNFα-induced cyclooxygenase 2 not only increases the vasopermeability of blood-brain barrier but also enhances the neutrophil survival in Escherichia coli-induced brain inflammation

1999 • 22 citations

The local edemogenic effects of leukotriene C4 and prostaglandin E2 in rats

1983 • 20 citations

Modulation of endothelial cell permeability by lung carcinoma cells: A potential mechanism of malignant pleural effusion formation

1994 • 18 citations

TNF-alpha-induced inhibition of PC synthesis by human type II pneumocytes is sequentially mediated by PGE2 and NO

1996 • 15 citations

Comparison of prostaglandin synthesis by endothelial cells from blood vessels originating in the rat, baboon, calf and human

1987 • 14 citations

16,16-dimethyl prostaglandin E2 modulation of endothelial monolayer paracellular barrier function

1996 • 11 citations

History and Basic Concepts

1993 • 5 citations