A co-culture-based model of human blood–brain barrier: application to active transport of indinavir and in vivo–in vitro correlation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency Syndrome

1985 • 1,103 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

A cell culture model of the blood-brain barrier.

1991 • 753 citations

An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

1990 • 534 citations

Dementia Associated with the Acquired Immunodeficiency Syndrome

1995 • 465 citations

Early penetration of the blood-brain-barrier by HIV.

1988 • 444 citations

Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells

1980 • 389 citations

Immunohistochemical identification of HTLV‐III antigen in brains of patients with AIDS

1986 • 380 citations

Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier

1992 • 319 citations

Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier.

1990 • 263 citations

Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

1986 • 246 citations

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1997 • 240 citations

Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term Culture

1989 • 210 citations

Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

1998 • 202 citations

P-glycoprotein multidrug resistance and cancer

1996 • 180 citations

Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier

1996 • 161 citations

In Vitro Blood–Brain Barrier Permeability of Nevirapine Compared to Other HIV Antiretroviral Agents

1998 • 150 citations

Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters

1998 • 146 citations

Interaction of Anti-HIV Protease Inhibitors With the Multidrug Transporter P-Glycoprotein (P-gp) in Human Cultured Cells

1998 • 144 citations

Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier

1997 • 144 citations

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.

1992 • 140 citations

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1998 • 139 citations

Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.

1988 • 139 citations

Competitive and Non‐Competitive Inhibition of the Multidrug‐Resistance‐Associated P‐glycoprotein ATPase

1997 • 134 citations

Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier.

2000 • 128 citations

The Susceptibility of Cerebral Endothelial Cells to Astroglial Induction of Blood‐Brain Barrier Enzymes Depends on Their Proliferative State

1991 • 120 citations

Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood–brain barrier

2001 • 120 citations

P-glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries

1999 • 100 citations

Effect of the P-Glycoprotein Inhibitor, Cyclosporine A, on the Distribution of Rhodamine-123 to the Brain: An in Vivo Microdialysis Study in Freely Moving Rats

1995 • 83 citations

Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.

1998 • 77 citations

Indinavir-based treatment of HIV-1 infected patients: efficacy in the central nervous system

1999 • 72 citations

A new model of the blood–brain barrier

1999 • 70 citations

Establishment of the Permanent Microvascular Endothelial Cell Line PBMEC/C1-2 from Porcine Brains

1996 • 65 citations

Comparative interleukin (IL-2)/interferon IFN-gamma and IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus.

1996 • 58 citations

ATP‐dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P‐glycoprotein

1994 • 56 citations

Absence of Cooperativity for MgATP and Verapamil Effects on the ATPase Activity of P-Glycoprotein Containing Membrane Vesicles

1993 • 47 citations

Multiple recognition of various amphiphilic molecules by the multidrug resistance P-glycoprotein: molecular mechanisms and pharmacological consequences coming from functional interactions between various drugs.

2000 • 44 citations

Cytokine mRNA Expression in Mononuclear Cells from Different Tissues during Acute SIVmac251 Infection of Macaques

1996 • 38 citations

Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form

1998 • 37 citations

Correlation between n-octanol/water partition coefficient and liquid chromatographic retention for caffeine and its metabolites, and some structure-pharmacokinetic considerations

1987 • 27 citations

Bispecific Antibody Targeting of Human Immunodeficiency Virus Type 1 (HIV-1) Glycoprotein 41 to Human Macrophages through the Fe IgG Receptor I Mediates Neutralizing Effects in HIV-1 Infection

1992 • 27 citations

Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model.

1998 • 25 citations

Techniques for quantification of cytokine mRNAs.

1998 • 23 citations

Protease Inhibitors May Reverse AIDS Dementia

1998 • 16 citations

Protease Inhibitors May Reverse AIDS Dementia

1998 • 4 citations