Telomeres and chromosome instability

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Switching and Signaling at the Telomere

2001 • 2,073 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2004 • 1,246 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Protection of mammalian telomeres

2002 • 926 citations

Telomere maintenance by recombination in human cells

2000 • 844 citations

The Genetic Basis of Human Cancer

1999 • 827 citations

Senescence Induced by Altered Telomere State, Not Telomere Loss

2002 • 787 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

TELOMERES AND THEIR CONTROL

2000 • 706 citations

Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

2004 • 585 citations

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

2001 • 552 citations

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

2001 • 525 citations

Frequent chromosomal translocations induced by DNA double-strand breaks

2000 • 498 citations

Different telomere damage signaling pathways in human and mouse cells

2002 • 475 citations

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

1998 • 432 citations

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

2001 • 422 citations

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

1998 • 414 citations

The Saccharomyces cerevisiae Helicase Rrm3p Facilitates Replication Past Nonhistone Protein-DNA Complexes

2003 • 402 citations

Telomerase activity in human cancer

1996 • 399 citations

Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons

1997 • 399 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

Telomere dynamics in an immortal human cell line.

1994 • 380 citations

Telomere Dysfunction Increases Mutation Rate and Genomic Instability

2001 • 377 citations

Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ

1999 • 377 citations

The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation

1994 • 371 citations

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

2001 • 354 citations

In situ analyses of genome instability in breast cancer

2004 • 354 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

DNA damage and repair in telomeres: relation to aging.

1995 • 326 citations

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

2001 • 323 citations

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

2003 • 316 citations

Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis

2004 • 310 citations

A role for common fragile site induction in amplification of human oncogenes

2002 • 294 citations

Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA

2002 • 273 citations

Repair of Site-Specific Double-Strand Breaks in a Mammalian Chromosome by Homologous and Illegitimate Recombination

1997 • 270 citations

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.

1991 • 248 citations

Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast

2000 • 229 citations

Chromosome Break-Induced DNA Replication Leads to Nonreciprocal Translocations and Telomere Capture

1998 • 215 citations

A New Role for Hypoxia in Tumor Progression

1998 • 211 citations

Oncogene amplification in solid tumors

1999 • 210 citations

Developmentally programmed healing of chromosomes by telomerase in tetrahymena

1991 • 204 citations

Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells.

1993 • 194 citations

Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity

2005 • 180 citations

DNA-PKcs is critical for telomere capping

2001 • 179 citations

Fragile sites still breaking

1998 • 178 citations

New telomeres in yeast are initiated with a highly selected subset of TG1-3 repeats.

1993 • 177 citations

DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell Line

2002 • 162 citations

When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation

2004 • 160 citations

Palindrome Resolution and Recombination in the Mammalian Germ Line

1997 • 160 citations

The Loss of a Single Telomere Can Result in Instability of Multiple Chromosomes in a Human Tumor Cell Line

2005 • 160 citations

Regulation of growth arrest in senescence: Telomere damage is not the end of the story

2005 • 158 citations

Chromosome rearrangements resulting from telomere dysfunction and their role in cancer

2004 • 155 citations

Telomere capture stabilizes chromosome breakage

1993 • 154 citations

The relationship between chromosome structure and function at a human telomeric region

1997 • 149 citations

Large inverted duplications are associated with gene amplification

1986 • 147 citations

Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells

1990 • 136 citations

Molecular characterization of a 130-kb terminal microdeletion at 22q in a child with mild mental retardation.

1997 • 136 citations

Telomere dynamics and genome instability in human cancer

1995 • 129 citations

Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks

2000 • 129 citations

Molecular genetics of breast cancer progression

1999 • 117 citations

Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells

2002 • 114 citations

Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes

2001 • 108 citations

Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats

2004 • 105 citations

Chromosome instability syndromes

2001 • 102 citations

A consistent pattern ofRIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification

2000 • 102 citations

Chromosome healing in mouse embryonic stem cells

1999 • 101 citations

Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification

2005 • 101 citations

End Resection Initiates Genomic Instability in the Absence of Telomerase

2003 • 100 citations

Homologous and Nonhomologous Recombination Resulting in Deletion: Effects of p53 Status, Microhomology, and Repetitive DNA Length and Orientation

2000 • 99 citations

The Relationship Between Spontaneous Telomere Loss and Chromosome Instability in a Human Tumor Cell Line

2000 • 89 citations

The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells

1993 • 79 citations

Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents

1980 • 76 citations

Repair of Chromosome Ends after Telomere Loss inSaccharomyces

2001 • 76 citations

Distance from the Chromosome End Determines the Efficiency of Double Strand Break Repair in Subtelomeres of Haploid Yeast

2003 • 74 citations

9 Telomeres and Aging

1995 • 72 citations

Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

2003 • 68 citations

Time Course Study of the Chromosome-Type Breakage-Fusion-Bridge Cycle in Maize

1999 • 64 citations

Analysis of Anaphase Figures in Routine Histologic Sections Distinguishes Chromosomally Unstable from Chromosomally Stable Malignancies

2003 • 62 citations

Recombination and the Tel1 and Mec1 checkpoints differentially effect genome rearrangements driven by telomere dysfunction in yeast

2004 • 62 citations

Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse

2001 • 62 citations

Characterization of Terminal Deletions at 7q32 and 22q13.3 Healed by De Novo Telomere Addition

2000 • 59 citations

Decoding the fine-scale structure of a breast cancer genome and transcriptome

2006 • 56 citations

Culture models of human mammary epithelial cell transformation.

2000 • 55 citations

Genomic Instability and Its Role in Neoplasia

1997 • 50 citations

Long Inverted Repeats Are an At-Risk Motif for Recombination in Mammalian Cells

1999 • 43 citations

Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM.

2003 • 43 citations

Alternative lengthening of telomeres: dangerous road less travelled

2003 • 40 citations

Telomere instability in a human cancer cell line

1999 • 37 citations

Oncogene amplification in transforming myelodysplasia

2005 • 23 citations