Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

Essential role of mouse telomerase in highly proliferative organs

1998 • 1,256 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

1999 • 462 citations

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

2000 • 402 citations

Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors

1996 • 377 citations

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

2000 • 375 citations

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

1999 • 373 citations

Telomerase activity associated with acquisition of malignancy in human colorectal cancer.

1995 • 361 citations

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

2000 • 346 citations

Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation

1997 • 204 citations

Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation.

1998 • 196 citations

Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer.

1997 • 189 citations

Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli

1988 • 157 citations

Genomic instability occurs in colorectal carcinomas but not in adenomas

1993 • 135 citations

Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers

2000 • 133 citations

Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis.

1998 • 67 citations

Somatic genetic events linked to the apc locus in intestinal adenomas of the min mouse

1996 • 35 citations