The relationship between chromosome structure and function at a human telomeric region

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Structure and function of telomeres

1991 • 3,524 citations

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1993 • 1,617 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

A genetic linkage map of the human genome

1987 • 913 citations

Telomeres: Beginning to Understand the End

1995 • 855 citations

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16

1994 • 805 citations

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

1995 • 804 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.

1991 • 665 citations

The yeast genome project: what did we learn?

1996 • 540 citations

The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions

1980 • 531 citations

Structure and polymorphism of human telomere-associated DNA

1990 • 382 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

Recombination at the human α-globin gene cluster: Sequence features and topological constraints

1987 • 345 citations

The highest gene concentrations in the human genome are in telomeric bands of metaphase chromosomes.

1992 • 342 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Chromosome bands, their chromatin flavors, and their functional features.

1992 • 316 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Reconstruction and analysis of human alu genes

1991 • 288 citations

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n

1990 • 288 citations

The structure of a human α-globin pseudogene and its relationship to α-globin gene duplication

1980 • 259 citations

Healing of broken human chromosomes by the addition of telomeric repeats.

1994 • 204 citations

Molecular characterisation of a hypervariable region downstream of the human alpha-globin gene cluster.

1986 • 204 citations

The William Allan memorial award address: X-chromosome inactivation and the location and expression of X-linked genes.

1988 • 180 citations

Stable length polymorphism of up to 260 kb at the tip of the short arm of human chromosome 16

1991 • 165 citations

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

1992 • 162 citations

Mammalian chromosome banding — an expression of genome organization

1989 • 161 citations

Molecular basis of length polymorphism in the human zeta-globin gene complex.

1983 • 156 citations

Prototypic sequences for human repetitive DNA

1992 • 152 citations

Clinical features and molecular analysis of the alpha thalassemia/mental retardation syndromes. I. Cases due to deletions involving chromosome band 16p13.3.

1990 • 129 citations

De novo truncation of chromosome 16p and healing with (TTAGGG)n in the alpha-thalassemia/mental retardation syndrome (ATR-16).

1993 • 86 citations

Minireview: cryptic translocations and telomere integrity.

1992 • 84 citations

A tight cluster of five unrelated human genes on chromosome 16q22.1

1993 • 83 citations

Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci

1996 • 77 citations

The IL-9 Receptor Gene (IL9R): Genomic Structure, Chromosomal Localization in the Pseudoautosomal Region of the Long Arm of the Sex Chromosomes, and Identification of IL9R Pseudogenes at 9qter, 10pter, 16pter, and 18pter

1995 • 75 citations

A previously undetected pseudogene in the human alpha globin gene cluster

1986 • 61 citations

Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere.

1993 • 61 citations

Conservation of Position and Sequence of a Novel, Widely Expressed Gene Containing the Major Human α-Globin Regulatory Element

1995 • 60 citations

Recombination within the human embryonic ζ-globin locus: A common ζ-ζ chromosome produced by gene conversion of the ψζ gene

1985 • 59 citations

A new hypervariable marker for the human alpha-globin gene cluster.

1988 • 57 citations

Structure and expression of the human θl globin gene

1988 • 53 citations

Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice

1994 • 45 citations

The gene for θ-globin is transcribed in human fetal erythroid tissues

1987 • 41 citations

The genetic basis for mental retardation

1996 • 41 citations

An unusually large (CA)n repeat in the region of divergence between subtelomeric alleles of human chromosome 16p

1992 • 16 citations

Cloning and Nucleotide Sequence Analysis of Human Embryonic ζ-Globin cDNA

1982 • 16 citations

Small cytoplasmicRoRNA pseudogene and anAlurepeat in the human α-1 globin gene

1988 • 15 citations

Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)

1992 • 13 citations

An expert system for processing sequence homology data.

1994 • 12 citations

Chromosome structure and eukaryotic gene organization

1991 • 11 citations

Characterization of the telomeric region of human chromosome 16p

1993 • 6 citations

Deep heat

1995 • 2 citations