Telomere instability in a human cancer cell line

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

1997 • 1,252 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

1990 • 632 citations

Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance

1996 • 592 citations

Regulation of telomere length and function by a Myb-domain protein in fission yeast

1997 • 500 citations

Telomeres in the mouse have large inter-chromosomal variations in the number of T ₂ AG ₃ repeats

1997 • 490 citations

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

1995 • 490 citations

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.

1992 • 480 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability

1990 • 436 citations

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

1997 • 406 citations

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1993 • 392 citations

Telomere dynamics in an immortal human cell line.

1994 • 380 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

Short telomeres on human chromosome 17p

1998 • 367 citations

Runaway telomere elongation caused by telomerase RNA gene mutations

1995 • 338 citations

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines

1996 • 337 citations

Involvement of the Silencer and UAS Binding Protein RAP1 in Regulation of Telomere Length

1990 • 326 citations

A simple method for simultaneous R- or G-banding and fluorescence in situ hybridization of small single-copy genes

1992 • 251 citations

Human telomeres: fusion and interstitial sites

1989 • 248 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

Identification of yeast mutants with altered telomere structure.

1986 • 243 citations

C-Terminal Truncation of RAP1 Results in the Deregulation of Telomere Size, Stability, and Function in Saccharomyces cerevisiae

1992 • 233 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.

1996 • 226 citations

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.

1991 • 218 citations

Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer.

1992 • 215 citations

Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation

1997 • 204 citations

Ndj1p, a Meiotic Telomere Protein Required for Normal Chromosome Synapsis and Segregation in Yeast

1997 • 199 citations

Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells.

1993 • 194 citations

Stringent sequence requirements for the formation of human telomeres.

1994 • 190 citations

Functional reintroduction of human telomeres into mammalian cells.

1991 • 186 citations

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

1994 • 177 citations

Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.

1994 • 168 citations

Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

1992 • 163 citations

Short telomeres on human chromosome 17p

1998 • 159 citations

CDC17: An essential gene that prevents telomere elongation in yeast

1985 • 156 citations

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.

1992 • 141 citations

Telomere directed fragmentation of mammalian chromosomes

1993 • 140 citations

Telomere dynamics and genome instability in human cancer

1995 • 129 citations

Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.

1992 • 108 citations

Telomere Length Dynamics in Telomerase-Positive Immortal Human Cell Populations

1998 • 105 citations

Specific DNA Replication Mutations Affect Telomere Length in Saccharomyces cerevisiae

1996 • 101 citations

Telomeric structure in cells with chromosome end associations

1993 • 78 citations

Fluorescence in situ hybridization with a synthetic (T<sub>2</sub>AG<sub>3</sub>)<sub>n</sub> polynucleotide detects several intrachromosomal telomere-like repeats on human chromosomes

1997 • 76 citations

Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break.

1993 • 62 citations

SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing throughout neoplastic progression of human fibroblasts

1992 • 59 citations

Telomeric associations in the progression of chromosome aberrations in pediatric solid tumors

1996 • 54 citations

Absence or low number of telomere repeats at junctions of dicentric chromosomes

1999 • 48 citations

Chromosomal Instability and Alterations of Telomeric Repeats in Irradiated Human Fibroblasts

1994 • 40 citations

Telomere Dynamics in a Human Cancer Cell Line

1999 • 36 citations

Effect of telomere length on telomeric gene expression

1996 • 33 citations

Telomere fusion as a mechanism for the progressive loss of the short arm of chromosome 11 in an anaplastic wilms' tumor

1994 • 30 citations

Dissociation of Telomere Dynamics from Telomerase Activity in Human Thyroid Cancer Cells

1998 • 29 citations

Chromosome changes characterizing in vitro response to radiation in human squamous cell carcinoma lines.

1993 • 23 citations

Clonal Telomeric Fusions and Chromosome Instability in a Subcutaneous Sacrococcygeal Myxopapillary Ependymoma

1998 • 20 citations

Telomeric fusion and chromosome instability in multiple tissues of a patient with mosaic Ullrich-Turner syndrome

1997 • 11 citations