Affinity maturation and class switching

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

T and B memory cells

1994 • 285 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

1990 • 237 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

1995 • 197 citations

What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

1992 • 179 citations

Regulation of antibody production and class switching by TGF-beta.

1995 • 141 citations

Mutational hot spots in Ig V region genes of human follicular lymphomas.

1988 • 86 citations

An immunoglobulin mutator that targets G.C base pairs.

1996 • 76 citations

Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.

1995 • 73 citations

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

1994 • 69 citations

Sites of B-cell activation in vivo

1993 • 68 citations

Regulation and Targeting of Recombination in Extrachromosomal Substrates Carrying Immunoglobulin Switch Region Sequences

1994 • 38 citations

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.

1995 • 37 citations

A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.

1995 • 29 citations

Transchromosomally derived Ig heavy chains.

1995 • 27 citations

Regulation and targeting of recombination in extrachromosomal substrates carrying immunoglobulin switch region sequences.

1994 • 25 citations

Somatic Mutations During an Immune Response inXenopusTadpoles

1995 • 22 citations

Biochemical Studies of Class Switch Recombination

1996 • 6 citations

Affinity Maturation on Rugged Landscapes

2018 • 4 citations