Somatic Mutations During an Immune Response inXenopusTadpoles

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Toward a layered immune system

1989 • 251 citations

The development and repertoire of B-1 cells (CD5 B cells)

1991 • 198 citations

What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

1992 • 179 citations

Production of large clones of histocompatible, fully identical clawed toads (Xenopus)

1975 • 172 citations

Antibody diversity in lower vertebrates—why is it so restricted?

1982 • 151 citations

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

1985 • 150 citations

Changes in the immune system during metamorphosis of Xenopus

1987 • 128 citations

Organization and rearrangement of immunoglobulin M genes in the amphibian Xenopus.

1988 • 85 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

Ontogeny of immunity in amphibians: Changes in antibody repertoires and appearance of adult major histocompatibility antigens in Xenopus

1979 • 77 citations

The ontogeny of diversification at the immunoglobulin heavy chain locus in Xenopus.

1991 • 63 citations

Identification of a candidate CD5 homologue in the amphibian Xenopus laevis.

1995 • 59 citations

Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis.

1990 • 58 citations

Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.

1989 • 36 citations

Stable Expression And Somatic Hypermutation Of Antibody V Regions In B-Cell Developmental Pathways

1989 • 17 citations

Sequences of Cμ and the V_H1 Family in LG7, a Clonable Strain of Xenopus, Homozygous for the Immunoglobulin Loci

1992 • 12 citations

IgH Diversity In an Individual With Only One Million B Lymphocytes

1993 • 12 citations

Putative immunoglobulin VH genes of the goldfish,Carassius auratus, detected by heterologous cross-hybridization with a murine VH probe

1986 • 10 citations