The Shape of Thrombomodulin and Interactions with Thrombin as Determined by Electron Microscopy

A player of many parts: The spotlight falls on thrombin's structure

1993 • 444 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 385 citations

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

1995 • 380 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 318 citations

Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy.

1992 • 309 citations

Trinodular structure of fibrinogen

1979 • 263 citations

A Model for Fibrinogen: Domains and Sequence

1985 • 257 citations

Thrombin structure and function

1991 • 250 citations

Carboxyl-terminal portions of the alpha chains of fibrinogen and fibrin. Localization by electron microscopy and the effects of isolated alpha C fragments on polymerization

1993 • 248 citations

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

1995 • 235 citations

Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.

1992 • 230 citations

Molecular Events that Control the Protein C Anticoagulant Pathway

1993 • 223 citations

Regulation of blood coagulation by the protein C system

1992 • 179 citations

The clot thickens: clues provided by thrombin structure

1995 • 177 citations

Proteoglycans of basement membranes

1993 • 166 citations

An allosteric switch controls the procoagulant and anticoagulant activities of thrombin.

1995 • 165 citations

Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors

1991 • 157 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor.

1986 • 125 citations

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

1990 • 117 citations

A domain Composed of Epidermal Growth Factor-like Structures of Human Thrombomodulin Is Essential for Thrombin Binding and for Protein C Activation

1989 • 109 citations

Structural Characterization of Two Variants of Fibulin-1 that Differ in Nidogen Affinity

1995 • 107 citations

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.

1992 • 105 citations

Proteolytic formation and properties of functional domains of thrombomodulin.

1987 • 98 citations

The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease

1995 • 95 citations

The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as determined by electron microscopy

1994 • 87 citations

Microthrombomodulin

1989 • 86 citations

Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin.

1988 • 81 citations

Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity.

1993 • 80 citations

Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin.

1994 • 80 citations

Preparation of single molecules and supramolecular complexes for high-resolution metal shadowing

1983 • 68 citations

Presence and function of chondroitin-4-sulfate on recombinant human soluble thrombomodulin

1990 • 66 citations

Structure-Function Relationships of the Thrombin-Thrombomodulin Interaction

1993 • 64 citations

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin

1994 • 62 citations

The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin.

1993 • 58 citations

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.

1993 • 57 citations

The Active Site of the Thrombin-Thrombomodulin Complex

1989 • 46 citations

Thrombomodulin and thrombin localization on the vascular endothelium; their internalization and transcytosis by plasmalemmal vesicles.

1993 • 46 citations

Active site and exosite binding of ??-thrombin

1993 • 39 citations

Spatial Structure of Thrombin as a Guide to Its Multiple Sites of Interaction

1993 • 33 citations

Proteoglycans from the swarm rat chondrosarcoma. Structure of the aggregates extracted with associative and dissociative solvents as revealed by electron microscopy.

1992 • 32 citations

Localization of thrombomodulin antigen in rabbit endothelial cells in culture. An immunofluorescence and immunoelectron microscope study.

1986 • 28 citations

Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin

1993 • 28 citations

Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects

1994 • 25 citations

Thermal Stability and Domain-Domain Interactions in Natural and Recombinant Protein C

1995 • 25 citations

Antithrombotic effects of recombinant human soluble thrombomodulin (rhs‐TM) on arteriovenous shunt thrombosis in rats

1994 • 23 citations

Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety

1992 • 23 citations

Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin

1995 • 22 citations

Antithrombotic Effects of Recombinant Human Soluble Thrombomodulin in a Rat Model of Vascular Shunt Thrombosis

1994 • 15 citations

Recombinant soluble human thrombomodulin: A randomized, blinded assessment of prevention of venous thrombosis and effects on hemostatic parameters in a rat model

1994 • 14 citations

Importance of the Arg-Gly-Asp Triplet in Human Thrombin for Maintenance of Structure and Function

1993 • 8 citations

The molecular weight and oligomerization of rabbit thrombomodulin as assessed by sedimentation equilibrium

1989 • 5 citations