Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Factor XI Activation in a Revised Model of Blood Coagulation

1991 • 774 citations

The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

1992 • 628 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Glycosaminoglycans and the regulation of blood coagulation

1993 • 425 citations

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.

1994 • 277 citations

Inflammation and Coagulation: Linked Processes Potentially Regulated Through a Common Pathway Mediated by Protein C

1991 • 261 citations

Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate

1991 • 261 citations

Human Protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide

1994 • 233 citations

Molecular Events that Control the Protein C Anticoagulant Pathway

1993 • 223 citations

Treatment of purpura fulminans in meningococcemia with protein C concentrate

1995 • 190 citations

Regulation of blood coagulation by the protein C system

1992 • 179 citations

Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C.

1994 • 177 citations

Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism.

1994 • 167 citations

Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors

1991 • 157 citations

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation.

1991 • 136 citations

On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies.

1995 • 132 citations

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

1991 • 129 citations

The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa. A fluorescence study.

1992 • 105 citations

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

1992 • 88 citations

Interaction of calcium with bovine plasma protein C

1981 • 88 citations

Inhibition and complexation of activated protein C by two major inhibitors in plasma

1989 • 88 citations

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin

1993 • 88 citations

Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity

1992 • 87 citations

Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays

1990 • 86 citations

Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.

1994 • 85 citations

Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin.

1994 • 80 citations

Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity.

1993 • 80 citations

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors.

1993 • 67 citations

Activation of protein C and its distribution between its inhibitors, protein C inhibitor, alpha 1-antitrypsin and alpha 2-macroglobulin, in patients with disseminated intravascular coagulation.

1993 • 63 citations

Protein structural requirements for Ca2+ binding to the light chain of factor X. Studies using isolated intact fragments containing the gamma-carboxyglutamic acid region and/or the epidermal growth factor-like domains

1991 • 62 citations

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin

1994 • 62 citations

Analysis of the functions of the first epidermal growth factor-like domain of factor X.

1993 • 59 citations

Characterization of the functional defect in factor IX Alabama. Evidence for a conformational change due to high affinity calcium binding in the first epidermal growth factor domain.

1990 • 59 citations

Heparin binding site, conformational change, and activation of antithrombin

1992 • 58 citations

Molecular mechanisms of thrombin signaling.

1994 • 55 citations

The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain.

1994 • 54 citations

Enhancing protein C interaction with thrombin results in a clot-activated anticoagulant

1992 • 49 citations

Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C.

1991 • 44 citations

Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy.

1994 • 40 citations

The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles

1993 • 40 citations

Thrombomodulin

1991 • 38 citations

Thrombomodulin Is a Cofactor for Thrombin Degradation of Recombinant Single-Chain Urokinase Plasminogen Activator "In Vitro" and in a Perfused Rabbit Heart Model

1992 • 33 citations

Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin

1994 • 32 citations

Enhanced endothelial tissue factor but normal thrombomodulin in endotoxin-treated rabbits

1993 • 30 citations

Calcium-dependence of the interactions between protein C, thrombin and the elastase fragment of thrombomodulin. Analysis by ultracentrifugation

1992 • 29 citations

Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin

1993 • 28 citations

Identification of structural domains in protein C involved in its interaction with thrombin-thrombomodulin on the surface of endothelial cells.

1992 • 25 citations

Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin

1993 • 24 citations

Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety

1992 • 23 citations

Proline at the P2 position in protein C is important for calcium- mediated regulation of protein C activation and secretion

1994 • 13 citations