A domain Composed of Epidermal Growth Factor-like Structures of Human Thrombomodulin Is Essential for Thrombin Binding and for Protein C Activation

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP

1986 • 717 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Preparation and properties of bovine factor VIII (antihemophilic factor)

1980 • 504 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

Inactivation of human coagulation factor V by activated protein C.

1983 • 374 citations

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

1987 • 358 citations

Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion

1981 • 245 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Preparation and partial characterization of two forms of bovine thrombin

1975 • 183 citations

The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin.

1985 • 149 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

Reconstitution of rabbit thrombomodulin into phospholipid vesicles.

1987 • 99 citations

Proteolytic formation and properties of functional domains of thrombomodulin.

1987 • 98 citations

Protein C Activation

1984 • 85 citations

Regulation of Activated Protein C by Thrombin-Modified Protein S1

1983 • 59 citations

The effect of phospholipids on the activation of protein C by the human thrombin-thrombomodulin complex

1986 • 53 citations

Gene Structure of Human Thrombomodulin, a Cofactor for Thrombin Catalyzed Activation of Protein C1

1988 • 52 citations

A New fluorogenic Peptide Substrate for Vitamin K-Dependent Blood Coagulation Factor, Bovine Protein C1

1981 • 44 citations

Efficient Conjugation of Rabbit Fab′ with β‐D‐Galactosidase from Escherichia coli

1979 • 40 citations