Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

1989 • 889 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Why are proteins O-glycosylated?

1990 • 708 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.

1985 • 413 citations

Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

1987 • 376 citations

Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 330 citations

Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.

1987 • 256 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1987 • 209 citations

Clearance of Thrombin from Circulation in Rabbits by High-affinity Binding Sites on Endothelium

1980 • 204 citations

Neutralization of heparin-related saccharides by histidine-rich glycoprotein and platelet factor 4.

1986 • 200 citations

Isolation and characterization of thrombomodulin from human placenta.

1984 • 197 citations

Pathobiology of the Endothelial Cell

1982 • 190 citations

Thrombin^a

1986 • 186 citations

Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain

1986 • 176 citations

Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors.

1988 • 158 citations

The Last Three Consecutive Epidermal Growth Factor-like Structures of Human Thrombomodulin Comprise the Minimum Functional Domain for Protein C-activating Cofactor Activity and Anticoagulant Activity

1989 • 149 citations

The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin.

1985 • 149 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

1990 • 117 citations

The effect of bovine thrombomodulin on the specificity of bovine thrombin.

1986 • 106 citations

A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice

1988 • 100 citations

Isolation and characterization of the glycosaminoglycan component of rabbit thrombomodulin proteoglycan.

1990 • 99 citations

Detecting distant homologies of mosaic proteins

1988 • 93 citations

Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays

1990 • 86 citations

Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin.

1988 • 81 citations

Further localization of binding sites for thrombin and protein C in human thrombomodulin

1990 • 80 citations

Functional domains of rabbit thrombomodulin.

1986 • 79 citations

Distribution of the thrombomodulin antigen in the rabbit vasculature.

1986 • 78 citations

Protein C and Related Proteins

1989 • 76 citations

Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin

1990 • 74 citations

Binding of thrombin to thrombomodulin accelerates inhibition of the enzyme by antithrombin III. Evidence for a heparin-independent mechanism

1987 • 70 citations

Presence and function of chondroitin-4-sulfate on recombinant human soluble thrombomodulin

1990 • 66 citations

Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin

1990 • 66 citations

Fetomodulin: Marker surface protein of fetal development which is modulatable by cyclic AMP

1987 • 64 citations

Expression of thrombomodulin by smooth muscle cells in culture: different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture

1991 • 64 citations

Domain structure of the endothelial cell receptor thrombomodulin as deduced from modulation of its anticoagulant functions. Evidence for a glycosaminoglycan-dependent secondary binding site for thrombin.

1990 • 53 citations

The Active Site of the Thrombin-Thrombomodulin Complex

1989 • 46 citations

Different glycoforms of human thrombomodulin

1991 • 46 citations

Isolation and characterization of thrombomodulin from bovine lung

1986 • 37 citations

Preparation of thrombomodulin from human placenta

1985 • 35 citations

The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin

1987 • 33 citations

Hirudin-based peptides block the inflammatory effects of thrombin on endothelial cells.

1990 • 31 citations

Localization of thrombomodulin antigen in rabbit endothelial cells in culture. An immunofluorescence and immunoelectron microscope study.

1986 • 28 citations

Relationship between post-translational glycosylation and anticoagulant function of secretable recombinant mutants of human thrombomodulin

1991 • 27 citations

Functional role of the polysaccharide component of rabbit thrombomodulin proteoglycan. Effects on inactivation of thrombin by antithrombin, cleavage of fibrinogen by thrombin and thrombin-catalysed activation of factor V

1990 • 26 citations

Effect of rabbit thrombomodulin on thrombin inhibition by antithrombin in the presence of heparin

1989 • 25 citations

Thrombomodulin inhibits the activation of factor xiii by thrombin

1986 • 24 citations

Decreased thrombin affinity of cell-surface thrombomodulin following treatment of cultured endothelial cells with β-D-xyloside

1990 • 23 citations

Differential expression of fetomodulin and tissue plasminogen activator to characterize parietal endoderm differentiation of F9 embryonal carcinoma cells

1990 • 18 citations

Physiological Role of Vessel Wall Related Antithrombotic Mechanisms: Contribution of Endogenous and Exogenous Heparin-Like Components to the Anticoagulant Potential of the Endothelium

1990 • 13 citations

Activation of Protein C by a Complex between Thrombin and Endothelial Cell Surface Protein

1982 • 12 citations

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