The Binding of Ku Antigen to Homeodomain Proteins Promotes Their Phosphorylation by DNA-dependent Protein Kinase

Protein modules and signalling networks

1995 • 2,447 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

The DNA-dependent protein kinase

1999 • 896 citations

HOMEODOMAIN PROTEINS

1994 • 828 citations

Homeodomain-DNA recognition

1994 • 784 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Combinatorial expression of three zebrafish genes related to distal- less: part of a homeobox gene code for the head

1994 • 607 citations

DNA end-joining: from yeast to man

1998 • 586 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

POU domain family values: flexibility, partnerships, and developmental codes.

1997 • 481 citations

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

1997 • 445 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Deletion of Ku86 causes early onset of senescence in mice

1999 • 360 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

Ku acts in a unique way at the mammalian telomere to prevent end joining

2000 • 338 citations

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

1997 • 315 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

1997 • 267 citations

Molecular Glue: Kinase Anchoring and Scaffold Proteins

1996 • 264 citations

Sensing and responding to DNA damage

2000 • 264 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

DNA Damage and Checkpoint Pathways

1998 • 251 citations

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

1998 • 238 citations

Ku70

1998 • 231 citations

Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II

1997 • 217 citations

A class act: conservation of homeodomain protein functions

1994 • 212 citations

SAP30, a Component of the mSin3 Corepressor Complex Involved in N-CoR-Mediated Repression by Specific Transcription Factors

1998 • 212 citations

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1996 • 211 citations

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase

1998 • 188 citations

Ku Autoantigen: A Multifunctional DNA-Binding Protein

2000 • 186 citations

DNA binding of Xrcc4 protein is associated with V(D)Jrecombination but not with stimulation of DNA ligase IV activity

1999 • 179 citations

A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

1992 • 134 citations

Isolation and Characterization of a Dual Prenylated Rab and VAMP2 Receptor

1997 • 122 citations

Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex

1998 • 120 citations

The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight

1996 • 115 citations

Sequential expression of multiple POU proteins during amphibian early development.

1992 • 102 citations

Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor

1998 • 101 citations

Outside and downstream of the homeobox.

1993 • 101 citations

Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit

1997 • 99 citations

Dissociation of Oct-1 from the Nuclear Peripheral Structure Induces the Cellular Aging-associated Collagenase Gene Expression

1997 • 94 citations

A Soluble Transcription Factor, Oct-1, Is Also Found in the Insoluble Nuclear Matrix and Possesses Silencing Activity in Its Alanine-Rich Domain

1996 • 92 citations

Activation of the transcription factor Oct-1 in response to DNA damage.

2000 • 83 citations

Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

1997 • 81 citations

Understanding the homeodomain.

1993 • 80 citations

p95^vavAssociates with the Nuclear Protein Ku-70

1996 • 79 citations

Sir-Ku-itous Routes to Make Ends Meet

1999 • 70 citations

Distinct HOX N-terminal Arm Residues Are Responsible for Specificity of DNA Recognition by HOX Monomers and HOX·PBX Heterodimers

1997 • 65 citations

Functions of the DNA dependent protein kinase.

1997 • 59 citations

Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors

2000 • 49 citations

The homeodomain-containing proteins

1999 • 44 citations

Telomeres: Moonlighting by DNA repair proteins

1998 • 33 citations

Ionizing radiation stimulates octamer factor DNA binding activity in human carcinoma cells.

1999 • 32 citations

Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription

1999 • 31 citations

Protein interactions of homeodomain proteins

1996 • 17 citations

Developmental Effects of Ectopic Expression of the Glucocorticoid Receptor DNA Binding Domain Are Alleviated by an Amino Acid Substitution That Interferes with Homeodomain Binding

1999 • 14 citations