Phosphatidylinositol 3-Kinase in HL-60 Nuclei Is Bound to the Nuclear Matrix and Increases During Granulocytic Differentiation

Oncogenes and signal transduction

1991 • 2,816 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase

1991 • 454 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

1992 • 321 citations

A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.

1992 • 278 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

Using structure to define the function of phosphoinositide 3‐kinase family members

1997 • 230 citations

Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells

1996 • 210 citations

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus

1993 • 165 citations

A New Phospholipase C δ4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus

1996 • 124 citations

Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.

1994 • 119 citations

Immunochemical characterization of protein kinase C in rat liver nuclei and subnuclear fractions

1987 • 108 citations

Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I.

1998 • 92 citations

Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.

1994 • 85 citations

Phosphoinositide 3-Kinase in Rat Liver Nuclei

1998 • 78 citations

Phosphatidylinositol 3-kinase activation in normal human B lymphocytes.

1996 • 72 citations

Activation of Protein Kinase C-ζ and Phosphatidylinositol 3′-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I

1998 • 69 citations

Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor.

1994 • 65 citations

Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells

1995 • 62 citations

Nuclear translocation of protein kinase C‐α and ‐ζ isoforms in HL‐60 cells induced to differentiate along the granulocytic lineage by all‐trans retinoic acid

1996 • 61 citations

A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulation of the Ca2+ dependency by polyphosphoinositides

1989 • 56 citations

Uptake and phosphorylation of phosphatidylinositol by rat liver nuclei. Role of phosphatidylinositol transfer protein

1990 • 49 citations

Intranuclear Translocation of Phospholipase C β2 during HL-60 Myeloid Differentiation

1997 • 48 citations

Lipid phosphorylation in isolated rat liver nuclei Synthesis of polyphosphoinositides at subnuclear level

1989 • 48 citations

The nuclear matrix: a critical appraisal.

1996 • 38 citations

Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells

1996 • 36 citations

Changes of Nuclear PI-PLC γ1 During Rat Liver Regeneration

1997 • 36 citations

Inositides in nuclei of friend cells: Changes of polyphosphoinositide and diacylglycerol levels accompany cell differentiation

1995 • 29 citations

Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO

1990 • 15 citations

Nuclear Scaffold Proteins Are Differently Sensitive to Stabilizing Treatment by Heat or Cu⁺⁺

1997 • 15 citations

Inositol lipids in friend erythroleukemia cells: Evidence for changes in nuclear metabolism after differntiation

1991 • 13 citations

Diacylglycerol kinase activity in rat liver nuclei

1994 • 12 citations