C5a Receptor Activation

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Dominant forces in protein folding

1990 • 3,682 citations

An Evolutionary Trace Method Defines Binding Surfaces Common to Protein Families

1996 • 1,214 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

A Transmembrane Helix Dimer: Structure and Implications

1997 • 949 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

PRINCIPLES THAT DETERMINE THE STRUCTURE OF PROTEINS

1984 • 645 citations

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

1997 • 639 citations

G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition

1997 • 585 citations

G Protein-coupled Receptors

1998 • 570 citations

Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

1997 • 565 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Arrangement of rhodopsin transmembrane α-helices

1997 • 449 citations

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

1994 • 418 citations

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

1996 • 389 citations

Agonists induce conformational changes in transmembrane domains III and VI of the beta 2 adrenoceptor

1997 • 378 citations

Structure and function of receptors coupled to G proteins

1994 • 377 citations

The family of G‐protein‐coupled receptors

1995 • 369 citations

GPCRDB: an information system for G protein-coupled receptors

1998 • 331 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.

1992 • 292 citations

Structural Features and Light-Dependent Changes in the Cytoplasmic Interhelical E−F Loop Region of Rhodopsin: A Site-Directed Spin-Labeling Study

1996 • 259 citations

The Thyrotropin Receptor in Thyroid Diseases

1997 • 246 citations

Two-site binding of C5a by its receptor: analternative binding paradigm for G protein-coupled receptors.

1994 • 236 citations

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.

1990 • 230 citations

Pheromone signalling and polarized morphogenesis in yeast

1997 • 221 citations

Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

1993 • 213 citations

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.

1995 • 204 citations

Constitutive Activation of the β2 Adrenergic Receptor Alters the Orientation of Its Sixth Membrane-spanning Segment

1997 • 186 citations

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.

1996 • 181 citations

Molecular architecture of G protein-coupled receptors

1996 • 178 citations

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

1992 • 175 citations

The role of conserved aspartate and serine residues in ligand binding and in function of the 5‐HT_1A receptor: A site‐directed mutation study

1992 • 164 citations

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

1995 • 162 citations

Mapping Light-Dependent Structural Changes in the Cytoplasmic Loop Connecting Helixes C and D in Rhodopsin: A Site-Directed Spin Labeling Study

1995 • 160 citations

A Cluster of Aromatic Residues in the Sixth Membrane-Spanning Segment of the Dopamine D2 Receptor Is Accessible in the Binding-Site Crevice

1998 • 159 citations

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

1992 • 157 citations

Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding.

1991 • 152 citations

Photoactivated Conformational Changes in Rhodopsin: A Time-Resolved Spin Label Study

1993 • 140 citations

Functional Coupling of a Mammalian Somatostatin Receptor to the Yeast Pheromone Response Pathway

1995 • 133 citations

Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic Acid

1998 • 118 citations

Targeted random mutagenesis: the use of ambiguously synthesized oligonucleotides to mutagenize sequences immediately 5‘ of an ATG initiation codon

1983 • 112 citations

Residues in the Seventh Membrane-Spanning Segment of the Dopamine D2 Receptor Accessible in the Binding-Site Crevice

1996 • 109 citations

Residues in the Fifth Membrane-Spanning Segment of the Dopamine D2 Receptor Exposed in the Binding-Site Crevice

1995 • 102 citations

Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-beta gamma subunit complex to rhodopsin using fluorescence spectroscopy.

1992 • 100 citations

Minireview: Constitutively Active G Protein-Coupled Receptors: Potential Mechanisms of Receptor Activation

1997 • 93 citations

Identification of a Ligand-dependent Switch within a Muscarinic Receptor

1998 • 88 citations

Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.

1995 • 80 citations

The Deletion of 14 Amino Acids in the Seventh Transmembrane Domain of a Naturally Occurring Calcitonin Receptor Isoform Alters Ligand Binding and Selectively Abolishes Coupling to Phospholipase C

1996 • 79 citations

A C-terminal peptide of bovine rhodopsin binds to the transducin α-subunit and facilitates its activation

1994 • 76 citations

The NH2-terminal region of C5aR but not that of FPR is critical for both protein transport and ligand binding.

1994 • 74 citations

Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy

1997 • 74 citations

A model of the lutropin/choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations

1997 • 72 citations

Structure of a G-protein-coupling Domain of a Muscarinic Receptor Predicted by Random Saturation Mutagenesis

1996 • 66 citations

Exploring the allowed sequence space of a membrane protein

1996 • 63 citations

Residues 21–30 within the Extracellular N-terminal Region of the C5a Receptor Represent a Binding Domain for the C5a Anaphylatoxin

1998 • 54 citations

Pharmacological characterization of the rat A2a adenosine receptor functionally coupled to the yeast pheromone response pathway.

1996 • 50 citations

Plugging it in: signaling circuits and the yeast cell cycle

1996 • 50 citations

[34] Mutagenesis with degenerate oligonucleotides: An efficient method for saturating a defined DNA region with base pair substitutions

1987 • 49 citations

Site‐Directed Mutagenesis of Conserved Charged Residues in the Helical Region of the Human C5a Receptor

1996 • 41 citations

Evidence for a role of the amino-terminal region in the biological activity of the classical anaphylatoxin, porcine C5a des-Arg-74.

1985 • 32 citations

Alternative splicing in human retinal mRNA transcripts of an opsin-related protein

1995 • 16 citations

Bovine thyrotropin receptor cDNA is characterized by full-length and truncated transcripts

1997 • 14 citations