Constitutively active mutants of rhodopsin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Assay of proteins in the presence of interfering materials

1976 • 3,217 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

A point mutation of the rhodopsin gene in one form of retinitis pigmentosa

1990 • 1,032 citations

Molecular Basis of Visual Excitation

1968 • 1,002 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.

1991 • 492 citations

Mutations within the Rhodopsin Gene in Patients with Autosomal Dominant Retinitis Pigmentosa

1990 • 478 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Rhodopsin mutations in autosomal dominant retinitis pigmentosa.

1991 • 455 citations

Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.

1987 • 444 citations

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

1992 • 439 citations

Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probes

1983 • 392 citations

Site of Attachment of Retinal in Rhodopsin

1967 • 352 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Characterization of bovine rod outer segment G-protein.

1982 • 281 citations

Resonance Raman spectroscopy of rhodopsin in retinal disk membranes

1974 • 274 citations

Photoisomerization, energy storage, and charge separation: A model for light energy transduction in visual pigments and bacteriorhodopsin

1979 • 270 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

The structure of rhodopsin and the rod outer segment disk membrane

1983 • 248 citations

The opsin family of proteins

1986 • 245 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Total synthesis of a gene for bovine rhodopsin.

1986 • 179 citations

Autosomal dominant retinitis pigmentosa: Four new mutations in rhodopsin, one of them in the retinal attachment site

1991 • 166 citations

Design, chemical synthesis, and expression of genes for the three human color vision pigments

1991 • 151 citations

Resonance Raman studies of bovine metarhodopsin I and metarhodopsin II

1978 • 146 citations

Transducin Activation by Rhodopsin Without a Covalent Bond to the 11- Cis -Retinal Chromophore

1991 • 114 citations

Deprotonation of the Schiff base of rhodopsin is obligate in the activation of the G protein.

1986 • 108 citations

The ligand-binding domain of rhodopsin and other G protein-linked receptors

1992 • 107 citations

Allosteric behavior in transducin activation mediated by rhodopsin. Initial rate analysis of guanine nucleotide exchange.

1987 • 105 citations

ACID-BASE PROPERTIES OF RHODOPSIN AND OPSIN

1956 • 95 citations

Autosomal dominant retinitis pigmentosa: absence of the rhodopsin proline----histidine substitution (codon 23) in pedigrees from Europe.

1990 • 88 citations

Receptor-effector coupling by G proteins

1990 • 56 citations

Insight into blindness

1990 • 14 citations