An Evolutionary Trace Method Defines Binding Surfaces Common to Protein Families

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Classical Electrostatics in Biology and Chemistry

1995 • 2,801 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Fast and sensitive multiple sequence alignments on a microcomputer

1989 • 1,245 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

The MIDAS display system

1988 • 955 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

Energetics of protein-protein interactions: Analysis ofthe Barnase-Barstar interface by single mutations and double mutant cycles

1995 • 559 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation

1993 • 534 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Crystal structure of a Src-homology 3 (SH3) domain

1992 • 474 citations

Prediction of protein secondary structure and active sites using the alignment of homologous sequences

1987 • 449 citations

A method to predict functional residues in proteins

1995 • 418 citations

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1994 • 310 citations

Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

1987 • 299 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1994 • 247 citations

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

1995 • 243 citations

Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

1994 • 208 citations

[25] Protein multiple sequence alignment and flexible pattern matching

1990 • 191 citations

Conic: A fast renderer for spacefilling molecules with shadows

1991 • 139 citations

Sh2 And Sh3 Domains In Signal Transduction

1994 • 138 citations

Prediction of secondary structure by evolutionary comparison: Application to the α subunit of tryptophan synthase

1987 • 134 citations

Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions.

1994 • 121 citations

Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.

1993 • 115 citations

The Molecular and Genetic Dissection of the Retinoid Signaling Pathway

1995 • 113 citations

Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition

1994 • 97 citations

Analysis and prediction of the location of catalytic residues in enzymes

1988 • 92 citations

Structural and functional basis for hormone binding and receptor oligomerization

1994 • 91 citations

Closing in on SH2 specificity

1993 • 86 citations

Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62

1992 • 78 citations

Patterns of divergence in homologous proteins as indicators of tertiary and quaternary structure

1989 • 69 citations

Bona Fide Prediction of Aspects of Protein Conformation

1994 • 53 citations

X-ray crystallographic identification of a protein-binding site for both all-trans- and 9-cis-retinoic acid.

1993 • 44 citations

The Crystal Structure of the N-terminal SH3 Domain of Grb2

1995 • 34 citations

Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.

1994 • 26 citations

Sequence divergence analysis for the prediction of seven-helix membrane protein structures: I. Comparison with bacteriorhodopsin

1994 • 14 citations

Synopses from the poster exhibition organized by I. M. Kerr, 1. Interferon: a tertiary structure predicted from amino acid sequences

1982 • 6 citations