Drosophila grim induces apoptosis in mammalian cells

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Caspases: killer proteases

1997 • 2,440 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Programmed cell death

1974 • 966 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

1995 • 685 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

grim, a novel cell death gene in Drosophila.

1996 • 414 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

1997 • 370 citations

Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture

1966 • 364 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells

1997 • 273 citations

Inhibition of Reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs)

1997 • 210 citations

Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells

1996 • 206 citations

Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM

1998 • 203 citations

Gene activation is required for developmentally programmed cell death.

1990 • 160 citations

Induction of apoptosis by the tumor suppressor protein BRCA1.

1996 • 140 citations

Activation of thereaperGene during Ectopic Cell Killing inDrosophila

1996 • 109 citations

Genes That Induce Apoptosis: Transcriptional Regulation in Identified, Doomed Neurons of theDrosophilaCNS

1997 • 89 citations

Facing death in the fly: genetic analysis of apoptosis in Drosophila

1997 • 82 citations

Reaper-induced apoptosis in a vertebrate system

1997 • 80 citations

Caenorhabditis elegans anti-apoptotic gene ced-9 prevents ced-3-induced cell death in Drosophila cells

1998 • 28 citations

Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo

1996 • 15 citations

Gene activation is required for developmentally programmed cell death.

1990 • 8 citations