Neurochemical brain imaging investigations of schizophrenia

Statistical parametric maps in functional imaging: A general linear approach

1994 • 9,606 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Molecular pathology of schizophrenia: more than one disease process?

1980 • 1,877 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Evidence for striatal dopamine release during a video game

1998 • 1,233 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types

1993 • 997 citations

The current status of the dopamine hypothesis of schizophrenia

1988 • 962 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

Dopamine receptors and the dopamine hypothesis of schizophrenia

1987 • 867 citations

Serotonin-dopamine interaction and its relevance to schizophrenia

1996 • 822 citations

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

1965 • 813 citations

Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort

1998 • 786 citations

Increased dopamine transmission in schizophrenia: relationship to illness phases

1999 • 713 citations

Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

1997 • 707 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

1993 • 690 citations

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

1995 • 687 citations

Dopamine D4 receptors elevated in schizophrenia

1993 • 632 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Provocative tests with psychostimulant drugs in schizophrenia

1987 • 535 citations

D2 Dopamine Receptors in Neuroleptic-Naive Schizophrenic Patients

1990 • 526 citations

INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIA

1978 • 513 citations

Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.

1993 • 495 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains

1995 • 458 citations

Reversible decreases in N‐acetylaspartate after acute brain injury

1995 • 441 citations

Human brain dopamine receptors in children and aging adults

1987 • 404 citations

Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia

1995 • 374 citations

Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics

1992 • 371 citations

The Role of Serotonin in Schizophrenia

1988 • 368 citations

SOME VIRUS ISOLATIONS FROM COMMON COLDS

1960 • 356 citations

Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains

1978 • 351 citations

Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics

1993 • 350 citations

Elevated dopa decarboxylase activity in living brain of patients with psychosis.

1994 • 335 citations

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy

1997 • 334 citations

Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients

1995 • 323 citations

Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases

1987 • 322 citations

In vivo ¹³ C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling

1997 • 315 citations

Endogenous dopamine lowers the dopamine D₂ receptor density as measured by [³H]raclopride: Implications for positron emission tomography of the human brain

1989 • 298 citations

Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease

1990 • 289 citations

5-HT1A and 5-HT2A Receptor mRNAs and Binding Site Densities Are Differentially Altered in Schizophrenia

1996 • 287 citations

Imaging dopamine transmission in schizophrenia. A review and meta-analysis.

1998 • 281 citations

Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates

1997 • 267 citations

Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides

1996 • 266 citations

Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

1997 • 266 citations

Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging

1996 • 263 citations

Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitro

1978 • 261 citations

INCREASED BRAIN DOPAMINE AND REDUCED GLUTAMIC ACID DECARBOXYLASE AND CHOLINE ACETYL TRANSFERASE ACTIVITY IN SCHIZOPHRENIA AND RELATED PSYCHOSES

1977 • 254 citations

Neurotransmitter Receptors in Frontal Cortex of Schizophrenics

1979 • 249 citations

Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia

1999 • 243 citations

Selective Abnormalities of Prefrontal Serotonergic Receptors in Schizophrenia

1993 • 234 citations

Measurement of Glutamate and Glutamine in the Medial Prefrontal Cortex of Never-Treated Schizophrenic Patients and Healthy Controls by Proton Magnetic Resonance Spectroscopy

1997 • 228 citations

Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11C]WAY-100635

1996 • 226 citations

Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics

1986 • 225 citations

Fluorinated benzamide neuroleptics—III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer

1995 • 217 citations

The role of serotonin in the pathophysiology and treatment of schizophrenia

1997 • 214 citations

Structural brain imaging in schizophrenia: a selective review

1999 • 214 citations

Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.

1989 • 208 citations

Proton Magnetic Resonance Spectroscopy: An Emerging Technology in Pediatric Neurology Research

1998 • 206 citations

Regionally Specific Neuronal Pathology in Untreated Patients with Schizophrenia: A Proton Magnetic Resonance Spectroscopic Imaging Study

1998 • 203 citations

An In Vivo Study of the Prefrontal Cortex of Schizophrenic Patients at Different Stages of Illness via Phosphorus Magnetic Resonance Spectroscopy

1995 • 203 citations

Quantitative ¹H spectroscopic imaging of human brain at 4.1 T using image segmentation

1996 • 200 citations

Neurotransmitters, receptors and neuropeptides in post‐mortem brains of chronic schizophrenic patients

1988 • 192 citations

Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia

1993 • 186 citations

Quantitative Functional Brain Imaging with Positron Emission Tomography

1998 • 185 citations

Alterations in the cortical serotonergic system in schizophrenia: A postmortem study

1997 • 182 citations

Methods in neurotransmitter receptor analysis

1991 • 178 citations

Striatal D2 Dopamine Receptor Characteristics in Neuroleptic-Naive Schizophrenic Patients Studied With Positron Emission Tomography

1994 • 177 citations

A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.

1994 • 175 citations

Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride

1996 • 174 citations

γ-AMINOBUTYRIC-ACID DEFICIENCY IN BRAIN OF SCHIZOPHRENIC PATIENTS

1979 • 171 citations

The New Atypical Antipsychotics

1994 • 168 citations

3H-flupenthixol binding in post-mortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors

1981 • 165 citations

Presynaptic dopaminergic function in the striatum of schizophrenic patients

1997 • 163 citations

Amphetamine‐stimulated dopamine release competes in vivo for [¹²³I]IBZM binding to the D2 receptor in nonhuman primates

1992 • 157 citations

Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride

1993 • 157 citations

D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene

1998 • 156 citations

Beyond the Dopamine Hypothesis

1989 • 155 citations

1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates

1994 • 155 citations

Abnormal frontal lobe phosphorous metabolism in bipolar disorder

1995 • 155 citations

Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients

1991 • 154 citations

Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia

1996 • 153 citations

Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies

1997 • 145 citations

[3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics

1987 • 141 citations

D₂ Dopamine Receptor Binding in the Basal Ganglia of Antipsychotic-Free Schizophrenic Patients

1994 • 137 citations

Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs.

1997 • 129 citations

Tritiated LSD Binding in Frontal Cortex in Schizophrenia

1981 • 125 citations

Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study

1997 • 121 citations

[3H]SCH 23390 labeled D1 dopamine receptors are unchanged in schizophrenia and Parkinson's disease

1985 • 120 citations

Dopamine D2 densities and the schizophrenic brain

1998 • 119 citations

Autoradiography with [3H]8-OH-DPAT reveals increases in 5-HT1A receptors in ventral prefrontal cortex in schizophrenia

1996 • 119 citations

Common Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic Imaging

1998 • 118 citations

Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects

1980 • 118 citations

Quantification of Neuroreceptors in the Living Human Brain: IV. Effect of Aging and Elevations of D₂-Like Receptors in Schizophrenia and Bipolar Illness

1997 • 116 citations

Proton Magnetic Resonance Spectroscopy (¹H MRS) of the Hippocampal Formation in Schizophrenia: A Pilot Study

1994 • 109 citations

Decreased frontal cortical serotonin2A receptors in schizophrenia

1996 • 109 citations

Study of chronic schizophrenics using ³¹P magnetic resonance chemical shift imaging

1992 • 107 citations

Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia

1995 • 104 citations

Quantification of Neuroreceptors in the Living Human Brain: III. D₂-Like Dopamine Receptors: Theory, Validation, and Changes during Normal Aging

1997 • 104 citations

Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia [published erratum appears in Am J Psychiatry 1997 May;154(5):722]

1997 • 101 citations

Synaptic Concentration of Dopamine in the Mouse Striatum in Relationship to the Kinetic Properties of the Dopamine Receptors and Uptake Mechanism

1991 • 100 citations

Serotonin 5-HT₂ Receptors in Schizophrenia: A PET Study Using [¹⁸F]Setoperone in Neuroleptic-Naive Patients and Normal Subjects

1999 • 100 citations

Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

1993 • 100 citations

Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain.

1991 • 99 citations

Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone

1993 • 99 citations

Dopamine in Schizophrenia

1996 • 93 citations

Amphetamine induced decreases in (¹⁸F)‐N‐methylspiroperidol binding in the baboon brain using positron emission tomography (PET)

1991 • 91 citations

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

1995 • 90 citations

Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy

1998 • 88 citations

Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report

1995 • 86 citations

High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides.

1991 • 85 citations

Workshop on Schizophrenia, PET, and Dopamine D2 Receptors in the Human Neostriatum

1988 • 85 citations

Dopaminergic mechanisms in schizophrenia: The antipsychotic effect and the disease process

1978 • 85 citations

Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls

1996 • 83 citations

Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: effects of chronic treatment with typical and atypical antipsychotic drugs.

1997 • 82 citations

Metabolite concentrations in the developing brain estimated with proton MR spectroscopy

1994 • 81 citations

No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET

1998 • 80 citations

Visualization of extrastriatal dopamine D2 receptors in the human brain

1992 • 79 citations

High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors

1991 • 75 citations

Quantitative autoradiography of dopamine-D1 receptors, D2 receptors, and dopamine uptake sites in postmortem striatal specimens from schizophrenic patients

1994 • 74 citations

Disrupted Pattern of D2 Dopamine Receptors in the Temporal Lobe in Schizophrenia

1997 • 72 citations

Metabolism of α-methyltyrosine in man: relationship to its potency as an inhibitor of catecholamine biosynthesis

1968 • 72 citations

Reduced [3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: Is selective loss of glutamatergic neurons associated with major psychoses?

1993 • 70 citations

Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action.

1983 • 67 citations

31Phosphorus magnetic resonance spectroscopy of the temporal lobes in schizophrenia

1992 • 65 citations

The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography

1992 • 65 citations

[ carbonyl - 11 C]Desmethyl-WAY-100635 (DWAY) is a potent and selective radioligand for central 5-HT 1A receptors in vitro and in vivo

1998 • 61 citations

A 1H-decoupled 31P chemical shift imaging study of medicated schizophrenic patients and healthy controls

1999 • 59 citations

Studies in postmortem dopamine uptake

1987 • 58 citations

Structural brain imaging in schizophrenia.

1995 • 55 citations

Kinetic properties of the in vivo accumulation of 3H-(?)-N-n-propylnorapomorphine in mouse brain

1989 • 52 citations

Atypicality of Several Antipsychotics on the Basis of In Vivo Dopamine-D2 and Serotonin-5HT2 Receptor Occupancy

1995 • 52 citations

Benzodiazepine receptors in the post-mortem brain of suicide victims and schizophrenic subjects

1997 • 51 citations

Initial investigation of the left temporoparietal region in schizophrenia by 31P magnetic resonance spectroscopy

1991 • 45 citations

The current status of PET scanning with respect to schizophrenia.

1992 • 44 citations

Evaluation of 5‐[¹⁸F]Fluoropropylepidepride as a potential pet radioligand for imaging dopamine D2 receptors

1993 • 41 citations

Atypicality of Several Antipsychotics on the Basis of In Vivo Dopamine-D2 and Serotonin-5HT2 Receptor Occupancy

1995 • 39 citations

18F-desmethoxyfallypride: A fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for pet imaging studies of dopamine D2 receptors

1996 • 39 citations

Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects

1996 • 37 citations

SPECT imaging of dopamine receptors with [123I]epidepride: characterization of uptake in the human brain

1995 • 37 citations

Dopamine D2-like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline

1997 • 35 citations

[3H] GBR 12935 binding to the dopamine uptake site in post-mortem brain tissue in schizophrenia

1989 • 32 citations

Striatal and extrastriatal imaging of dopamine D2 receptors in the living human brain with [123I]epidepride single-photon emission tomography

1997 • 29 citations

Critical reevaluation of spiperone and benzamide binding to dopamine D2 receptors: evidence for identical binding sites

1996 • 28 citations

Pharmacodynamic comparison of the acute effects of nomifensine, amphetamine and placebo in healthy volunteers.

1979 • 25 citations

The study of schizophrenia via in vivo 31P and 1H MRS

1993 • 12 citations

Quantitative functional brain imaging with positron emission tomography

1998 • 9 citations

Serotonin receptor responsivity in schizophrenia

1993 • 8 citations

Quantification of Extracellular Dopamine Release in Schizophrenia and Cocaine Use by Means of TREMBLE 1 1Transcripts of the BRAINPET97 discussion of this chapter can be found in Section VIII.

1998 • 8 citations

Dopaminergic mechanisms in schizophrenia.

1977 • 5 citations

The relationship between prefrontal neuronal integrity and striatal amphetamine-induced dopamine activity in patients with schizophrenia

1998 • 3 citations

Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects

1995 • 2 citations