Atypicality of Several Antipsychotics on the Basis of In Vivo Dopamine-D2 and Serotonin-5HT2 Receptor Occupancy

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors

1993 • 334 citations

The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs.

1989 • 321 citations

Mechanisms of action of atypical antipsychotic drugs

1991 • 254 citations

5-HT2 and D2 dopamine receptor occupancy in the living human brain

1993 • 228 citations

Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.

1992 • 192 citations

Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.

1993 • 170 citations

In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.

1992 • 146 citations

Comparison of [3H]YM-09151-2 with [3H]spiperone and [3H]raclopride for dopamine D-2 receptor binding to rat striatum

1989 • 123 citations

High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET

1993 • 108 citations

Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo.

1993 • 98 citations

An open clinical and biochemical study of ritanserin in acute patients with schizophrenia

1994 • 97 citations

In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain

1982 • 91 citations

Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.

1987 • 91 citations

Zotepine in the treatment of schizophrenic patients with prevailingly negative symptoms. A double-blind trial vs. haloperidol

1992 • 80 citations

Benzodiazepine receptor binding with [3H]-Ro 15-1788

1985 • 76 citations

Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat

1988 • 74 citations

Characterization of Two [³H]Ketanserin Recognition Sites in Rat Striatum

1987 • 67 citations

In vivo dopamine-D2 and serotonin-5-HT2 receptor binding study of risperidone and haloperidol

1994 • 54 citations

Zotepine vs. haloperidol in paranoid schizophrenia: a double-blind trial.

1989 • 53 citations

Serotonin, dopamine and their interactions in schizophrenia

1993 • 45 citations

Multiple receptor responses: A new concept to describe the relationship between pharmacological effects and pharmacokinetics of a drug: Studies on clonidine in the rat and cat

1979 • 41 citations

Neuroleptic-induced acute dyskinesias in rhesus monkeys

1981 • 41 citations

D2-dopamine receptor specific brain uptake of carbon-11-labeled YM-09151-2.

1989 • 38 citations

Which Atypical Antipsychotics Are Identified by Screening Tests?

1989 • 32 citations

RMI-81,582, a novel antipsychotic drug

1980 • 23 citations

Time course of dopamine1,2 and serotonin2 receptor binding of antipsychotics in vivo

1994 • 21 citations

The cimetidine-induced increase in prolactin secretion in schizophrenia: effect of clozapine

1993 • 17 citations

LIMBIC SELECTIVE NEUROLEPTICS

1992 • 16 citations

A single-blind study of clocapramine and sulpiride in hospitalized chronic schizophrenic patients.

1988 • 6 citations

Effects of the novel antipsychotics, RMI 81582 and clopipazan, on predictors of extrapyramidal liability in squirrel monkeys

1983 • 5 citations

Deleted Work

1955 • 0 citations