How Transcriptional Activators Bind Target Proteins

Transcriptional activation by recruitment

1997 • 1,163 citations

Speeding molecular recognition by using the folding funnel: The fly-casting mechanism

2000 • 963 citations

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

1997 • 714 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

Activators and targets

1990 • 582 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc

1999 • 427 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

The role of c-myc in cellular growth control

1999 • 383 citations

Structure and function of transcriptional activation domains

1995 • 376 citations

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

2000 • 330 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

1997 • 286 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis

2000 • 261 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Mysterious liaisons: the relationship between c-Myc and the cell cycle

1999 • 229 citations

Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein

1989 • 198 citations

An Activator Target in the RNA Polymerase II Holoenzyme

1998 • 195 citations

Quantitation of putative activator-target affinities predicts transcriptional activating potentials.

1996 • 195 citations

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

2000 • 194 citations

Action of Myc in vivo — proliferation and apoptosis

2000 • 193 citations

Interpretation of binding curves obtained with high receptor concentrations: practical aid for computer analysis.

1995 • 182 citations

Kinetic analysis of yeast TFIID-TATA box complex formation suggests a multi-step pathway.

1992 • 178 citations

New Myc-interacting proteins: a second Myc network emerges

1999 • 178 citations

Generating yeast transcriptional activators containing no yeast protein sequences

1991 • 178 citations

Transcription factor access to chromatin

1997 • 168 citations

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

1995 • 160 citations

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

1994 • 158 citations

The Transcriptional Activator GCN4 Contains Multiple Activation Domains That Are Critically Dependent on Hydrophobic Amino Acids

1995 • 156 citations

Analysis of an Activator:Coactivator Complex Reveals an Essential Role for Secondary Structure in Transcriptional Activation

1998 • 155 citations

c-Myc induces the expression and activity of ornithine decarboxylase.

1993 • 152 citations

CBP/p300 histone acetyl-transferase activity is important for the G1/S transition

2000 • 139 citations

RNA Polymerase II Holoenzyme Recruitment Is Sufficient to Remodel Chromatin at the Yeast PHO5 Promoter

1997 • 133 citations

myc Boxes, Which Are Conserved in myc Family Proteins, Are Signals for Protein Degradation via the Proteasome

1998 • 130 citations

Transactivation Ability of p53 Transcriptional Activation Domain Is Directly Related to the Binding Affinity to TATA-binding Protein

1995 • 124 citations

Yeast TATA binding protein interaction with DNA: fluorescence determination of oligomeric state, equilibrium binding, on-rate, and dissociation kinetics

1995 • 123 citations

Gene activation by recruitment of the RNA polymerase II holoenzyme.

1996 • 123 citations

A small amphipathic alpha -helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

2000 • 121 citations

Functional Interaction of the c-Myc Transactivation Domain with the TATA Binding Protein: Evidence for an Induced Fit Model of Transactivation Domain Folding

1996 • 109 citations

The AD1 Transactivation Domain of E2A Contains a Highly Conserved Helix Which Is Required for Its Activity in both Saccharomyces cerevisiae and Mammalian Cells

1996 • 108 citations

Role of Acidic and Phosphorylated Residues in Gene Activation by the Glucocorticoid Receptor

1995 • 107 citations

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.

1994 • 104 citations

Delineation of a small region within the majortransactivation domain of the human glucocorticoid receptor that mediatestransactivation of gene expression.

1994 • 98 citations

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

1990 • 94 citations

Dissection of the Transactivation Function of the Transcription Factor Encoded by the Eye Developmental Gene PAX6

1998 • 87 citations

Intrinsic Structural Disorder of the C-Terminal Activation Domain from the bZIP Transcription Factor Fos

2000 • 85 citations

Structural motifs at protein‐protein interfaces: Protein cores versus two‐state and three‐state model complexes

1997 • 84 citations

Role of Important Hydrophobic Amino Acids in the Interaction between the Glucocorticoid Receptor τ1-Core Activation Domain and Target Factors

1998 • 78 citations

Transcriptional activation domains stimulate initiation and elongation at different times and via different residues

1998 • 76 citations

Role of Hydrophobic Amino Acid Clusters in the Transactivation Activity of the Human Glucocorticoid Receptor

1997 • 67 citations

Transcriptional Cofactor CA150 Regulates RNA Polymerase II Elongation in a TATA-Box-Dependent Manner

1999 • 62 citations

Characterization of the Amino-terminal Activation Domain of Peroxisome Proliferator-activated Receptor α

1999 • 44 citations

Structural Studies of Mutant Glucocorticoid Receptor Transactivation Domains Establish a Link between Transactivation Activity in Vivo and α-Helix-Forming Potential in Vitro

1996 • 43 citations

Transcriptional activation by artificial recruitment in mammalian cells

1999 • 42 citations

DNA-binding domain of human c-Myc produced in Escherichia coli.

1989 • 40 citations

The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60

1997 • 39 citations

Solution conformation of an essential region of the p53 transactivation domain

1997 • 38 citations

Activation of Transcription In Vitro by Recruitment of the Yeast RNA Polymerase II Holoenzyme

1998 • 37 citations

Structural analysis of the human papillomavirus type 16-E2 transactivator with antipeptide antibodies reveals a high mobility region linking the transactivation and the DNA-binding domains

1991 • 33 citations

Critical Amino Acids in the Transcriptional Activation Domain of the Herpesvirus Protein VP16 Are Solvent-exposed in Highly Mobile Protein Segments

1996 • 31 citations

Architectural Principles for the Structure and Function of the Glucocorticoid Receptor τ1 Core Activation Domain

2000 • 30 citations

The Influence of Signal Noise on the Accuracy of Kinetic Constants Measured by Surface Plasmon Resonance Experiments

1999 • 28 citations

Gene Transcription by Recruitment

1998 • 26 citations

Mechanisms of Viral Activators

1998 • 25 citations

The minimal transactivation region of Saccharomyces cerevisiae Gln3p is localized to 13 amino acids

1997 • 19 citations