Speeding molecular recognition by using the folding funnel: The fly-casting mechanism

The Energy Landscapes and Motions of Proteins

1991 • 3,100 citations

Reversible Unfolding of Individual Titin Immunoglobulin Domains by AFM

1997 • 2,985 citations

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1999 • 2,867 citations

Funnels, pathways, and the energy landscape of protein folding: A synthesis

1995 • 2,607 citations

From Levinthal to pathways to funnels

1997 • 2,277 citations

THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective

1997 • 2,102 citations

Structural chemistry and molecular biology

1968 • 1,698 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers

1997 • 1,198 citations

Navigating the Folding Routes

1995 • 1,193 citations

Temperature-dependent X-ray diffraction as a probe of protein structural dynamics

1979 • 1,136 citations

Facilitated Target Location in Biological Systems

1989 • 1,011 citations

Protein folding funnels: a kinetic approach to the sequence-structure relationship.

1992 • 923 citations

Theoretical Studies of Protein Folding

1983 • 831 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Intermediates and barrier crossing in a random energy model (with applications to protein folding)

1989 • 748 citations

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

1995 • 745 citations

Elasticity and unfolding of single molecules of the giant muscle protein titin

1997 • 735 citations

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

1997 • 714 citations

Lac represser-operator interaction

1973 • 699 citations

A simple model for calculating the kinetics of protein folding from three-dimensional structures

1999 • 631 citations

Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity.

1996 • 562 citations

Toward an outline of the topography of a realistic protein-folding funnel.

1995 • 510 citations

Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures

1999 • 390 citations

Role of the hydrophobic effect in stability of site-specific protein-DNA complexes

1989 • 380 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

The nature of folded states of globular proteins

1992 • 378 citations

Diffusion controlled reaction rates in spheroidal geometry

1974 • 344 citations

A theoretical search for folding/unfolding nuclei in three-dimensional protein structures

1999 • 315 citations

Folding kinetics of proteinlike heteropolymers

1994 • 263 citations

Modular structure of transcription factors: Implications for gene regulation

1991 • 260 citations

Folding dynamics with nonadditive forces: A simulation study of a designed helical protein and a random heteropolymer

1999 • 193 citations

A genetic switch : phage λ and higher organisms

1992 • 175 citations

Exploring the folding free energy surface of a three-helix bundle protein

1997 • 159 citations

p22 Arc Repressor: Folding Kinetics of a Single-Domain, Dimeric Protein

1994 • 138 citations

Structural correlations in protein folding funnels

1997 • 126 citations

Exploring structures in protein folding funnels with free energy functionals: the transition state ensemble

1999 • 108 citations

Variational Theory for Site Resolved Protein Folding Free Energy Surfaces

1998 • 107 citations

The structure of interfaces between subunits of dimeric and tetrameric proteins

1989 • 103 citations

Evidence for Conformation Changes Induced by Substrates of Phosphoglucomutase

1965 • 103 citations

DNA specificity enhanced by sequential binding of protein monomers

1999 • 102 citations

Improved design of stable and fast-folding model proteins

1996 • 76 citations

Exploring structures in protein folding funnels with free energy functionals: the denatured ensemble

1999 • 67 citations

DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor

1998 • 67 citations

Backbone dynamics, fast folding, and secondary structure formation in helical proteins and peptides

1999 • 63 citations

Tolerance of Arc repressor to multiple-alanine substitutions

1999 • 58 citations

Acceleration of the refolding of Arc repressor by nucleic acids and other polyanions.

1999 • 57 citations

Assembly of the arc repressor-operator complex: cooperative interactions between DNA-bound dimers

1993 • 55 citations

How GCN4 binds DNA

1993 • 31 citations

Interaction of Lac Repressor with Non-Specific DNA Binding Sites

1975 • 21 citations