The minimal transactivation region of Saccharomyces cerevisiae Gln3p is localized to 13 amino acids

Experiments in molecular genetics

1972 • 28,260 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

Combining evolutionary information and neural networks to predict protein secondary structure

1994 • 1,471 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains

1987 • 887 citations

The Molecular Biology of the Yeast Saccharomyces (Metabolism and Gene Expression)

1985 • 712 citations

A new class of yeast transcriptional activators

1987 • 706 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Helix Signals in Proteins

1988 • 648 citations

Activators and targets

1990 • 582 citations

Correlation of Two-Hybrid Affinity Data with In Vitro Measurements

1995 • 536 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

Acid blobs and negative noodles

1988 • 438 citations

A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains

1987 • 408 citations

Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit

1987 • 324 citations

Nitrogen Catabolite Repression in Yeasts and Filamentous Fungi

1985 • 315 citations

The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.

1991 • 276 citations

Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting

1996 • 268 citations

Three Functional Classes of Transcriptional Activation Domains

1996 • 267 citations

Nitrogen Metabolism in Saccharomyces cerevisiae

1982 • 203 citations

Quantitation of putative activator-target affinities predicts transcriptional activating potentials.

1996 • 195 citations

Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain.

1991 • 195 citations

Regulation of nitrogen assimilation in Saccharomyces cerevisiae: roles of the URE2 and GLN3 genes

1988 • 186 citations

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

1995 • 160 citations

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

1994 • 158 citations

The acidic activation domains of the GCN4 and GAL4 proteins are not α helical but form β sheets

1993 • 151 citations

Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression.

1991 • 150 citations

Regulation of glutamine-repressible gene products by the GLN3 function in Saccharomyces cerevisiae.

1984 • 139 citations

Gat1p, a GATA Family Protein Whose Production Is Sensitive to Nitrogen Catabolite Repression, Participates in Transcriptional Activation of Nitrogen-Catabolic Genes in Saccharomyces cerevisiae

1996 • 138 citations

Structure(?) and function of acidic transcription activators

1993 • 136 citations

Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae

1993 • 135 citations

A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.

1995 • 132 citations

Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae

1997 • 123 citations

Two-Dimensional Crystallography of TFIIB– and IIE–RNA Polymerase II Complexes: Implications for Start Site Selection and Initiation Complex Formation

1996 • 113 citations

Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae

1996 • 109 citations

Functional Interaction of the c-Myc Transactivation Domain with the TATA Binding Protein: Evidence for an Induced Fit Model of Transactivation Domain Folding

1996 • 109 citations

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.

1994 • 104 citations

Ureidosuccinic Acid Uptake in Yeast and Some Aspects of Its Regulation

1972 • 103 citations

Drosophila tissue-specific transcription factor NTF-1 contains a novel isoleucine-rich activation motif.

1993 • 101 citations

Gzf3p, a fourth GATA factor involved in nitrogen‐regulated transcription in Saccharomyces cerevisiae

1997 • 93 citations

Yeast mutants pleiotropically impaired in the regulation of the two glutamate dehydrogenases

1973 • 90 citations

Transcriptional regulation of the DAL5 gene in Saccharomyces cerevisiae

1987 • 90 citations

Transcriptional Activation Domain of the Herpesvirus Protein VP16 Becomes Conformationally Constrained upon Interaction with Basal Transcription Factors

1996 • 89 citations

Studies on Transcription Activation by the Multimeric CCAAT-binding Factor CBF

1995 • 86 citations

The GLN3 gene product is required for transcriptional activation of allantoin system gene expression in Saccharomyces cerevisiae

1990 • 84 citations

The URE2 Gene Product of Saccharomyces cerevisiae Plays an Important Role in the Cellular Response to the Nitrogen Source and Has Homology to Glutathione S-Transferases

1991 • 80 citations

Complilation and characteristics of dedicated transcription factors in Saccharomyces cerevisiae

1995 • 79 citations

Identification of sequences responsible for transcriptional activation of the allantoate permease gene in Saccharomyces cerevisiae.

1989 • 79 citations

Sequence and Expression of GLN3, a Positive Nitrogen Regulatory Gene of Saccharomyces cerevisiae Encoding a Protein with a Putative Zinc Finger DNA-Binding Domain

1991 • 78 citations

Saturation mutagenesis of the UASNTR (GATAA) responsible for nitrogen catabolite repression-sensitive transcriptional activation of the allantoin pathway genes in Saccharomyces cerevisiae

1991 • 75 citations

The Saccharomyces cerevisiae DAL80 repressor protein binds to multiple copies of GATAA-containing sequences (URSGATA)

1993 • 74 citations

The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.

1994 • 70 citations

Expression of the DAL80 Gene, Whose Product Is Homologous to the GATA Factors and Is a Negative Regulator of Multiple Nitrogen Catabolic Genes in Saccharomyces cerevisiae, Is Sensitive to Nitrogen Catabolite Repression

1991 • 68 citations

Genetic evidence for Gln3p-independent, nitrogen catabolite repression-sensitive gene expression in Saccharomyces cerevisiae

1995 • 67 citations

Isolation and Characterization of Mutants that Produce the Allantoin-Degrading Enzymes Constitutively in Saccharomyces cerevisiae

1982 • 65 citations

Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene

1995 • 65 citations

The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae

1994 • 63 citations

Positive and negative regulatory elements control the expression of the UGA4 gene coding for the inducible 4‐aminobutyric‐acid‐specific permease in Saccharomyces cerevisiae

1989 • 63 citations

The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains both a GATA-1 type zinc finger and a putative leucine zipper

1992 • 60 citations

Roles of URE2 and GLN3 in the Proline Utilization Pathway in Saccharomyces cerevisiae

1995 • 60 citations

Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae

1996 • 60 citations

GNP1, the high-affinity glutamine permease of S. cerevisiae

1996 • 57 citations

G1n3p is capable of binding to UAS(NTR) elements and activating transcription in Saccharomyces cerevisiae

1996 • 56 citations

Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae

1997 • 56 citations

Requirement of upstream activation sequences for nitrogen catabolite repression of the allantoin system genes in Saccharomyces cerevisiae.

1989 • 55 citations

The URE2 protein regulates nitrogen catabolic gene expression through the GATAA-containing UASNTR element in Saccharomyces cerevisiae

1994 • 53 citations

Regulation of Glutamine-Repressible Gene Products by the GLN3 Function in Saccharomyces cerevisiae

1984 • 53 citations

Two mutually exclusive regulatory systems inhibit UAS^GATA, a cluster of 5′-GAT(A/T)A-3′ upstream from theUGA4gene ofSaccharomyces cerevisiae

1995 • 51 citations

Transcriptional activation in yeast by the proline-rich activation domain of human CTF1.

1993 • 48 citations

TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription

1995 • 44 citations

Functional Analysis of the PUT3 Transcriptional Activator of the Proline Utilization Pathway in Saccharomyces cerevisiae

1996 • 43 citations

A Minimal Transcription Activation Domain Consisting of a Specific Array of Aspartic Acid and Leucine Residues

1994 • 41 citations

Identification of Sequences Responsible for Transcriptional Activation of the Allantoate Permease Gene in Saccharomyces cerevisiae

1989 • 41 citations

Dissection of the bifunctional ARGRII protein involved in the regulation of arginine anabolic and catabolic pathways.

1991 • 37 citations

Mutational Analysis of the Transcription Activation Domain of RelA: Identification of a Highly Synergistic Minimal Acidic Activation Module

1994 • 36 citations

Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.

1996 • 33 citations

Critical Amino Acids in the Transcriptional Activation Domain of the Herpesvirus Protein VP16 Are Solvent-exposed in Highly Mobile Protein Segments

1996 • 31 citations

Requirement of Upstream Activation Sequences for Nitrogen Catabolite Repression of the Allantoin System Genes in Saccharomyces cerevisiae

1989 • 28 citations

The regulatory protein NIT4 that mediates nitrate induction inNeurospora crassa contains a complex tripartite activation domain with a novel leucine-rich, acidic motif

1996 • 24 citations

The Oct-2 Glutamine-Rich and Proline-Rich Activation Domains Can Synergize with Each Other or Duplicates of Themselves To Activate Transcription

1994 • 23 citations

Dissection of the Bifunctional ARGRII Protein Involved in the Regulation of Arginine Anabolic and Catabolic Pathways

1991 • 23 citations

Regulation of Allantoin Catabolism in Saccharomyces cerevisiae

1996 • 22 citations

Efficient PCR-based random mutagenesis of sub-genic (100 bp) DNA fragments

1998 • 14 citations

The embryonic transcription factor stage specific activator protein contains a potent bipartite activation domain that interacts with several RNA polymerase II basal transcription factors.

1996 • 12 citations